Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Apoptosis
FAS
NFκB2
colon cancer
pirin
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
26 Dec 2023
26 Dec 2023
Historique:
revised:
17
11
2023
received:
06
03
2023
medline:
27
12
2023
pubmed:
27
12
2023
entrez:
27
12
2023
Statut:
aheadofprint
Résumé
Resistance to immunotherapy in colorectal cancer (CRC) is associated with obstruction of FAS (Apo-1 or CD95)-dependent apoptosis, a hallmark of cancer. Here it is demonstrated that the upregulation of pirin (PIR) protein in colon cancers promotes tumorigenesis. Knockout or inhibition of PIR dramatically increases FAS expression, FAS-dependent apoptosis and attenuates colorectal tumor formation in mice. Specifically, NFκB2 is a direct transcriptional activator of FAS and robustly suppressed by PIR in dual mechanisms. One is the disruption of NFκB2 complex (p52-RELB) association with FAS promoter, the other is the inhibition of NIK-mediated NFκB2 activation and nuclear translocation, leading to the inability of active NFκB2 complex toward the transcription of FAS. Furthermore, PIR interacts with FAS and recruits it in cytosol, preventing its membrane translocation and assembling. Importantly, knockdown or knockout of PIR dramatically sensitizes cells to FAS mAb- or active CD8
Identifiants
pubmed: 38148593
doi: 10.1002/advs.202301476
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301476Subventions
Organisme : National Natural Science Foundation of China
ID : U21A20373
Organisme : National Natural Science Foundation of China
ID : 91857102
Organisme : National Natural Science Foundation of China
ID : 32100601
Organisme : National Natural Science Foundation of China
ID : 32070749
Organisme : China Postdoctoral Science Foundation
ID : 2021M691885
Organisme : Xiamen Municipal Bureau of Science and Technology
ID : 3502Z20193023
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Références
W. M. F. Wendler, E. Kremmer, R. Förster, E.-L. Winnacker, J. Biol. Chem. 1997, 272, 8482.
Y. Zhang, E. V. Knatko, M. Higgins, S. Dayalan Naidu, G. Smith, T. Honda, L. de la Vega, A. T. Dinkova-Kostova, Antioxidants 2022, 11, 262.
G. Zhu, L. Reynolds, T. Crnogorac-Jurcevic, C. E. Gillett, E. A. Dublin, J. F. Marshall, D. Barnes, C. D'arrigo, P. O. Van Trappen, N. R. Lemoine, I. R. Hart, Oncogene 2003, 22, 3742.
a) S. Licciulli, C. Luise, A. Zanardi, L. Giorgetti, G. Viale, L. Lanfrancone, R. Carbone, M. Alcalay, BMC Cell Biol. 2010, 11, 5;
b) S. Licciulli, C. Luise, G. Scafetta, M. Capra, G. Giardina, P. Nuciforo, S. Bosari, G. Viale, G. Mazzarol, C. Tonelli, L. Lanfrancone, M. Alcalay, Am. J. Pathol. 2011, 178, 2397.
a) C. Adeniran, D. Hamelberg, Biochemistry 2017, 56, 5002;
b) S. Licciulli, V. Cambiaghi, G. Scafetta, A. M. Gruszka, M. Alcalay, Leukemia 2010, 24, 429.
R. Dechend, F. Hirano, K. Lehmann, V. Heissmeyer, S. Ansieau, F. G. Wulczyn, C. Scheidereit, A. Leutz, Oncogene 1999, 18, 3316.
F. Liu, I. Rehmani, S. Esaki, R. Fu, L. Chen, V. De Serrano, A. Liu, Proc. Natl. Acad. Sci. USA 2013, 110, 9722.
a) K. Brzóska, T. M. Stepkowski, M. Kruszewski, Mol. Cell. Biochem. 2014, 389, 99;
b) M. J. Kerins, A. Ooi, Antioxid Redox Signal 2018, 29, 1756.
a) I. De Freitas, M. Fernández-Somoza, E. Essenfeld-Sekler, J. E. Cardier, Chest 2004, 125, 2238;
b) W. J. Wurzer, C. Ehrhardt, S. Pleschka, F. Berberich-Siebelt, T. Wolff, H. Walczak, O. Planz, S. Ludwig, J. Biol. Chem. 2004, 279, 30931.
a) D. Bernhard, S. Skvortsov, I. Tinhofer, H. Hübl, R. Greil, A. Csordas, R. Kofler, Cell Death Differ. 2001, 8, 1014;
b) Q. Fu, T.-M. Fu, A. C. Cruz, P. Sengupta, S. K. Thomas, S. Wang, R. M. Siegel, H. Wu, J. J. Chou, Mol. Cell 2016, 61, 602;
c) P. Golstein, Science 2000, 288, 2328;
d) T. Kaufmann, A. Strasser, P. J. Jost, Cell Death Differ. 2012, 19, 42;
e) T. Knight, D. Luedtke, H. Edwards, J. W. Taub, Y. Ge, Biochem. Pharmacol. 2019, 162, 250.
a) F. H. Igney, P. H. Krammer, Nat. Rev. Cancer 2002, 2, 277;
b) S. Strand, W. J. Hofmann, H. Hug, M. Müller, G. Otto, D. Strand, S. M. Mariani, W. Stremmel, P. H. Krammer, P. R. Galle, Nat. Med. 1996, 2, 1361;
c) J. Peli, EMBO J. 1999, 18, 1824.
a) V. N. Ivanov, P. Lopez Bergami, G. Maulit, T. A. Sato, D. Sassoon, Z. Ronai, Mol. Cell. Biol. 2003, 23, 3623;
b) V. N. Ivanov, Z. Ronai, T. K. Hei, J. Biol. Chem. 2006, 281, 1840.
a) X. Dolcet, D. Llobet, J. Pallares, X. Matias-Guiu, Virchows Arch. 2005, 446, 475;
b) R. Schreck, K. Albermann, P. A. Baeuerle, Free Radic. Res. Commun. 1992, 17, 221.
a) T. D. Gilmore, Oncogene 2006, 25, 6680;
b) S.-C. Sun, Cell Res. 2011, 21, 71;
c) Nat. Rev. Immunol. 2017, 17, 545.
K. Meyerovich, M. Fukaya, L. F. Terra, F. Ortis, D. L. Eizirik, A. K. Cardozo, Diabetologia 2016, 59, 512.
Y. Wang, H. Cui, A. Schroering, J. L. Ding, W. S. Lane, G. Mcgill, D. E. Fisher, H.-F. Ding, Nat. Cell Biol. 2002, 4, 888.
I. Miyazaki, S. Simizu, H. Okumura, S. Takagi, H. Osada, Nat. Chem. Biol. 2010, 6, 667.
a) A. Liberzon, C. Birger, H. Thorvaldsdóttir, M. Ghandi, J. P. Mesirov, P. Tamayo, Cell Syst. 2015, 1, 417;
b) A. Subramanian, P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, S. L. Pomeroy, T. R. Golub, E. S. Lander, J. P. Mesirov, Proc. Natl. Acad. Sci. USA 2005, 102, 15545.
a) T. Li, L. Su, Y. Lei, X. Liu, Y. Zhang, X. Liu, J. Biol. Chem. 2015, 290, 11108;
b) M. Wang, P. Su, Syst. Biol. Reprod. Med. 2018, 64, 93.
A. Loboda, M. V. Nebozhyn, J. W. Watters, C. A. Buser, P. M. Shaw, P. S. Huang, L. Van't Veer, R. A. Tollenaar, D. B. Jackson, D. Agrawal, H. Dai, T. J. Yeatman, BMC Med. Genomics 2011, 4, 9.
a) C. L. Guo, Y. M. Bi, Z. Liu, Y. Xu, Y. X. Sun, Q. C. Wang, Zhonghua Gan. Zang Bing Za Zhi 2018, 26, 125;
b) H. U. Simon, S. Yousefi, C. C. Dommann-Scherrer, D. R. Zimmermann, S. Bauer, J. Barandun, K. Blaser, J. Exp. Med. 1996, 183, 1071;
c) T. S. Griffith, T. Brunner, S. M. Fletcher, D. R. Green, T. A. Ferguson, Science 1995, 270, 1189.
T. Kitamura, D. Doughty-Shenton, J. W. Pollard, N. O. Carragher, J. Vis. Exp. 2019, 143, 1.
a) I. Atreya, M. F. Neurath, Expert Rev. Anticancer. Ther. 2008, 8, 561;
b) G. Bindea, B. Mlecnik, M. Tosolini, A. Kirilovsky, M. Waldner, A. C. Obenauf, H. Angell, T. Fredriksen, L. Lafontaine, A. Berger, P. Bruneval, W. H. Fridman, C. Becker, F. Pagès, M. R. Speicher, Z. Trajanoski, J. Galon, Immunity 2013, 39, 782.
A. Strasser, P. J. Jost, S. Nagata, Immunity 2009, 30, 180.
I. Suzuki, P. J. Fink, J. Exp. Med. 1998, 187, 123.
a) J. Zhu, C. G. Powis De Tenbossche, S. Cané, D. Colau, N. Van Baren, C. Lurquin, A.-M. Schmitt-Verhulst, P. Liljeström, C. Uyttenhove, B. J. Van Den Eynde, Nat. Commun. 2017, 8, 1404;
b) R. D. Cervantes-Villagrana, D. Albores-García, A. R. Cervantes-Villagrana, S. J. García-Acevez, Signal Transduct. Target Ther. 2020, 5, 99.
F. Liu, K. Bardhan, D. Yang, M. Thangaraju, V. Ganapathy, J. L. Waller, G. B. Liles, J. R. Lee, K. Liu, J. Biol. Chem. 2012, 287, 25530.
M. Gu, X. Zhou, J. H. Sohn, L. Zhu, Z. Jie, J.-Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng, S.-C. Sun, Nat. Immunol. 2021, 22, 193.
P. Darvin, S. M. Toor, V. Sasidharan Nair, E. Elkord, Exp. Mol. Med. 2018, 50, 1.
T. S. Nowicki, S. Hu-Lieskovan, A. Ribas, Cancer J. 2018, 24, 47.
W. Xiao, M. L. Ibrahim, P. S. Redd, J. D. Klement, C. Lu, D. Yang, N. M. Savage, K. Liu, Mol. Cancer Res. 2019, 17, 420.
a) M. Fichtner, E. Bozkurt, M. Salvucci, C. Mccann, K. A. Mcallister, L. Halang, H. Düssmann, S. Kinsella, N. Crawford, T. Sessler, D. B. Longley, J. H. M. Prehn, Cell Death Dis. 2020, 11, 1020;
b) J. Guinney, R. Dienstmann, X. Wang, A. De Reyniès, A. Schlicker, C. Soneson, L. Marisa, P. Roepman, G. Nyamundanda, P. Angelino, B. M. Bot, J. S. Morris, I. M. Simon, S. Gerster, E. Fessler, F. De Sousa E Melo, E. Missiaglia, H. Ramay, D. Barras, K. Homicsko, D. Maru, G. C. Manyam, B. Broom, V. Boige, B. Perez-Villamil, T. Laderas, R. Salazar, J. W. Gray, D. Hanahan, J. Tabernero, et al., Nat. Med. 2015, 21, 1350;
c) B. Alessandro, S. Valeria, M. Tania, C. Luca, G. Riccardo, B. Rossana, Immunotherapy in colorectal cancer treatment: actual landscape and future perspectives 2018, 4, 55.
J. Jozefczuk, K. Drews, J. Adjaye, J. Vis. Exp. 2012, 64, 1.
K. Peng, L. Kou, L. Yu, C. Bai, M. Li, P. Mo, W. Li, C. Yu, Gastroenterology 2019, 156, 1112.
H. Ma, J. Zhang, L. Zhou, S. Wen, H.-Y.u Tang, B. Jiang, F. Zhang, M. Suleman, D. Sun, A.i Chen, W. Zhao, F. Lin, M.-T. Tsau, L.u-M. Shih, C. Xie, X. Li, D. Lin, L.i-M. Hung, M.-L. Cheng, Q. Li, Cell Rep. 2020, 30, 4235.
J. D. Taylor, A. J. Ackroyd, S. E. Halford, Methods Mol. Biol. 1994, 30, 263.