Evaluation of a diagnostic platelet aggregation test strategy for platelet rich plasma samples with low platelet counts.
hemostatic disorders
platelet aggregation
platelet count
platelet function tests
thrombocytopenia
Journal
International journal of laboratory hematology
ISSN: 1751-553X
Titre abrégé: Int J Lab Hematol
Pays: England
ID NLM: 101300213
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
29
08
2023
accepted:
25
11
2023
pubmed:
27
12
2023
medline:
27
12
2023
entrez:
27
12
2023
Statut:
ppublish
Résumé
Light transmission aggregometry (LTA) is important for diagnosing platelet function disorders (PFD) and von Willebrand disease (VWD) affecting ristocetin-induced platelet aggregation (RIPA). Nonetheless, data is lacking on the utility of LTA for investigating thrombocytopenic patients and platelet rich plasma samples with low platelet counts (L-PRP). Previously, we developed a strategy for diagnostic LTA assessment of L-PRP that included: (1) acceptance of referrals/samples, regardless of thrombocytopenia severity, (2) tailored agonist selection, based on which are informative for L-PRP with mildly or severely low platelet counts, and (3) interpretation of maximal aggregation (MA) using regression-derived 95% confidence intervals, determined for diluted control L-PRP (C-L-PRP). To further evaluate the L-PRP LTA strategy, we evaluated findings for a subsequent patient cohort. Between 2008 and 2021, the L-PRP strategy was applied to 211 samples (11.7% of all LTA samples) from 192 unique patients, whose platelet counts (median [range] × 10 Diagnostic LTA with L-PRP, using a strategy that considers thrombocytopenia severity, is feasible and informative.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
362-374Subventions
Organisme : McMaster University
Informations de copyright
© 2023 The Authors. International Journal of Laboratory Hematology published by John Wiley & Sons Ltd.
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