Iodoquinazoline-derived VEGFR-2 and EGFR

ADMET Anticancer Iodoquinazoline Tyrosine kinase

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
25 Dec 2023
Historique:
received: 29 09 2023
revised: 20 11 2023
accepted: 23 12 2023
medline: 28 12 2023
pubmed: 28 12 2023
entrez: 27 12 2023
Statut: aheadofprint

Résumé

Herein, we report the synthesis of a series of new fourteen iodoquinazoline derivatives 7a-c to 13a-e and their evaluation as potential anticancer agents via dual targeting of EGFR

Identifiants

DOI: 10.1016/j.bioorg.2023.107062 PMID: 38150938
pubmed: 38150938
pii: S0045-2068(23)00723-X
doi: 10.1016/j.bioorg.2023.107062
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107062

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Abeer A Mohamed (AA)

Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Egyptian Drug Authority (EDA), 51 Wezaret El-Zeraa St, Dokki, Giza, A. R., Egypt.

Sanadelaslam S A El-Hddad (SSA)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya.

Ahmed K B Aljohani (AKB)

Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia.

Fathalla Khedr (F)

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt.

Omar M Alatawi (OM)

Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 47512, Saudi Arabia.

Doaa E Keshek (DE)

Department of Biology, Jumum College University, Umm Al-Qura University, P.O Box7388, Makkah 21955, Sudia Arabia; Agriculture Genetic Engineering Research Institute (AGERI), Agriculture Research Centre, Giza, Egypt.

Sahar Ahmed (S)

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Marwa Alsulaimany (M)

Department of Pharmacognosy & Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.

Sara A Almadani (SA)

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.

Khaled El-Adl (K)

Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt. Electronic address: eladlkhaled74@yahoo.com.

Noura S Hanafy (NS)

Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.

Classifications MeSH