Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples.

Amygdala Anxiety Autism spectrum disorder (ASD) Magnetic resonance imaging (MRI) Reproducibility

Journal

Developmental cognitive neuroscience
ISSN: 1878-9307
Titre abrégé: Dev Cogn Neurosci
Pays: Netherlands
ID NLM: 101541838

Informations de publication

Date de publication:
22 Dec 2023
Historique:
received: 13 06 2023
revised: 18 12 2023
accepted: 19 12 2023
medline: 29 12 2023
pubmed: 29 12 2023
entrez: 28 12 2023
Statut: aheadofprint

Résumé

Amygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high- and low-familial likelihood for ASD, Infant Brain Imaging Study (IBIS, n = 257) and typically developing (TD) community sample, Early Brain Development Study (EBDS, n = 158). Infants underwent MRI scanning at up to 3 timepoints from neonate to 24 months. Anxiety was assessed at 6-12 years. Linear multilevel modeling tested whether amygdala volume growth was associated with anxiety symptoms at school age. In the IBIS sample, children with higher anxiety showed accelerated amygdala growth from 6 to 24 months. ASD diagnosis and ASD familial likelihood were not significant predictors. In the EBDS sample, amygdala growth from birth to 24 months was associated with anxiety. More anxious children had smaller amygdala volume and slower rates of amygdala growth. We explore reasons for the contrasting results between high-familial likelihood for ASD and TD samples, grounding results in the broader literature of variable associations between early amygdala volume and later anxiety. Results have the potential to identify mechanisms linking early amygdala growth to later anxiety in certain groups.

Identifiants

DOI: 10.1016/j.dcn.2023.101333 PMID: 38154378
pubmed: 38154378
pii: S1878-9293(23)00138-X
doi: 10.1016/j.dcn.2023.101333
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101333

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no financial or personal relationships that influenced their work.

Auteurs

Catherine A Burrows (CA)

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. Electronic address: cburrows@umn.edu.

Carolyn Lasch (C)

Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.

Julia Gross (J)

Carolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Jessica B Girault (JB)

Carolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Joshua Rutsohn (J)

Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Jason J Wolff (JJ)

Department of Educational Psychology, University of Minnesota, Minneapolis, MN, USA.

Meghan R Swanson (MR)

School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.

Chimei M Lee (CM)

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Stephen R Dager (SR)

Deptartment of Radiology, University of Washington Medical Center, Seattle, WA, USA.

Emil Cornea (E)

Center for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Rebecca Stephens (R)

Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Martin Styner (M)

Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Tanya St John (TS)

University of Washington Autism Center, University of Washington, Seattle, WA, USA.

Juhi Pandey (J)

Center for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Meera Deva (M)

Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Kelly N Botteron (KN)

Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Annette M Estes (AM)

University of Washington Autism Center, University of Washington, Seattle, WA, USA; Deptartment of Speech and Hearing Science, University of Washington, Seattle, WA, USA.

Heather C Hazlett (HC)

Carolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

John R Pruett (JR)

Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Robert T Schultz (RT)

Center for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Lonnie Zwaigenbaum (L)

Deptartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.

John H Gilmore (JH)

Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Mark D Shen (MD)

Carolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Joseph Piven (J)

Carolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Jed T Elison (JT)

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.

Classifications MeSH