Apigenin analogs as α-glucosidase inhibitors with antidiabetic activity.
Antidiabetic studies
Molecular docking
α-Glucosidase inhibition
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
25 Dec 2023
25 Dec 2023
Historique:
received:
31
10
2023
revised:
14
12
2023
accepted:
23
12
2023
medline:
29
12
2023
pubmed:
29
12
2023
entrez:
28
12
2023
Statut:
aheadofprint
Résumé
This study investigated the inhibitory potential of a series of synthesized compounds (L1-L27) on α-glucosidase. Among them, compound L22 showed significant inhibitory effect. Through enzymatic kinetics studies, we demonstrated that L22 acts via a non-competitive inhibition mode with a K
Identifiants
pubmed: 38154388
pii: S0045-2068(23)00720-4
doi: 10.1016/j.bioorg.2023.107059
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107059Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.