The Role of Preprocedure Genetic Counseling in Pregnancies Interrupted for Fetal Abnormalities.


Journal

American journal of perinatology
ISSN: 1098-8785
Titre abrégé: Am J Perinatol
Pays: United States
ID NLM: 8405212

Informations de publication

Date de publication:
28 Dec 2023
Historique:
medline: 29 12 2023
pubmed: 29 12 2023
entrez: 28 12 2023
Statut: aheadofprint

Résumé

 Congenital birth defects affect 3 to 5% of pregnancies. Genetic counseling can help patients navigate the testing process and understand results. The study objective was to identify predictors and utility of genetic counseling at the time of pregnancy termination. Additionally, we aimed to see what proportion of patients would benefit from additional testing based on the results of the genetic testing.  This was a retrospective cohort review of all terminations performed for fetal anomalies by an academic center from July 2016 to May 2020. Indications were stratified by abnormal serum screening or types of abnormal ultrasound findings. Data were abstracted regarding uptake of genetic counseling and testing results. Abnormal results that warranted additional testing regarding recurrence risks were noted. Multivariable logistic regression was performed to identify predictors of receipt of genetic counseling and testing.  Of 387 patients, 57% (  Genetic counseling was associated with increased uptake of diagnostic testing, which yielded useful information and prompted additional testing. This is important for determining etiology and recurrence risk and should be offered to patients presenting for termination for fetal indications, as well as providing diagnostic closure for patients. · Genetic counseling increases the uptake of diagnostic testing in patients with fetal anomalies.. · Patients with ultrasound anomalies received less diagnostic testing despite actionable results 36% of the time.. · Genetic testing is invaluable for recurrence risk counseling even if patients chose to terminate..

Identifiants

pubmed: 38154468
doi: 10.1055/s-0043-1777706
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Alex A Francoeur (AA)

Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California.

Sung-Hae L Kang (SL)

Department of Pathology and Laboratory medicine, University of California, Los Angeles, California.

T Niroshi Senaratne (TN)

Department of Pathology and Laboratory medicine, University of California, Los Angeles, California.

Sulagna Saitta (S)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.
Department of Human Genetics, University of California, Los Angeles, California.

Aparna Murali (A)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Katharine Peters (K)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Emily Hansman (E)

David Geffen School of Medicine, Los Angeles, California.

Angela Chen (A)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Ram Parvataneni (R)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Rajita Patil (R)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Radhika Rible (R)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Aparna Sridhar (A)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Amy Stoddard (A)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Mya Zapata (M)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Deborah Krakow (D)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.
Department of Orthopedic Surgery, University of California, Los Angeles, California.
Department of Human Genetics, University of California, Los Angeles, California.

Ilina D Pluym (ID)

Department of Obstetrics and Gynecology, University of California, Los Angeles, California.

Classifications MeSH