Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010-2021 in a tertiary teaching hospital of South China.

carbapenem-resistant Klebsiella pneumoniae intensive care unit pyogenic liver abscess

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
26 Dec 2023
Historique:
received: 18 02 2023
revised: 06 12 2023
accepted: 18 12 2023
medline: 29 12 2023
pubmed: 29 12 2023
entrez: 28 12 2023
Statut: aheadofprint

Résumé

Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. Klebsiella pneumoniae is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of K. pneumoniae-induced pyogenic liver abscess (KP-PLA), particularly those caused by carbapenem-resistant K. pneumoniae (CRKP). PLA patients from January 2010 to December 2021 were performed to investigate the differences of K. pneumoniae from other etiologically infected PLA patients (N-KP-PLA). Univariate and multivariate logistic regression analyses were performed to compare prognostic factors between patients with carbapenem-resistant K. pneumoniae PLA (CRKP-PLA) and patients with carbapenem-sensitive K. pneumoniae PLA (CSKP-PLA). Univariate analysis demonstrated a significant association between KP-PLA and factors, including diabetes mellitus (P < 0.001), cholecystitis and cholelithiasis (P = 0.032), single abscess (P = 0.016) and abscesses with a diameter over 50 mm (P = 0.004), the CRKP group exhibited a higher prevalence of therapeutic interventions prior to K. pneumoniae infection, including abdominal surgery, mechanical ventilation, sputum suction, tracheal cannula, routine drainage of the abdominal cavity, and peripherally inserted central venous catheters (P< 0.05).Multivariate logistic regression analysis revealed that admission to the intensive care unit (ICU) was an independent risk factor associated with CRKP-PLA (odds ratio, 36; 95% confidence interval, 1.77-731.56; P = 0.020). The KP-PLA patients were significantly associated with diabetes and were more likely to have single abscesses larger than 50-mm. PLA patients with a history of admission to ICU or invasive therapeutic procedures should be given special consideration if combined with CRKP infection.

Sections du résumé

BACKGROUND BACKGROUND
Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. Klebsiella pneumoniae is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of K. pneumoniae-induced pyogenic liver abscess (KP-PLA), particularly those caused by carbapenem-resistant K. pneumoniae (CRKP).
METHODS METHODS
PLA patients from January 2010 to December 2021 were performed to investigate the differences of K. pneumoniae from other etiologically infected PLA patients (N-KP-PLA). Univariate and multivariate logistic regression analyses were performed to compare prognostic factors between patients with carbapenem-resistant K. pneumoniae PLA (CRKP-PLA) and patients with carbapenem-sensitive K. pneumoniae PLA (CSKP-PLA).
RESULTS RESULTS
Univariate analysis demonstrated a significant association between KP-PLA and factors, including diabetes mellitus (P < 0.001), cholecystitis and cholelithiasis (P = 0.032), single abscess (P = 0.016) and abscesses with a diameter over 50 mm (P = 0.004), the CRKP group exhibited a higher prevalence of therapeutic interventions prior to K. pneumoniae infection, including abdominal surgery, mechanical ventilation, sputum suction, tracheal cannula, routine drainage of the abdominal cavity, and peripherally inserted central venous catheters (P< 0.05).Multivariate logistic regression analysis revealed that admission to the intensive care unit (ICU) was an independent risk factor associated with CRKP-PLA (odds ratio, 36; 95% confidence interval, 1.77-731.56; P = 0.020).
CONCLUSION CONCLUSIONS
The KP-PLA patients were significantly associated with diabetes and were more likely to have single abscesses larger than 50-mm. PLA patients with a history of admission to ICU or invasive therapeutic procedures should be given special consideration if combined with CRKP infection.

Identifiants

DOI: 10.1016/j.jgar.2023.12.024 PMID: 38154752
pubmed: 38154752
pii: S2213-7165(23)00237-0
doi: 10.1016/j.jgar.2023.12.024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interests The authors declare that they have no competing interests.

Auteurs

Jinqing Liu (J)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: 228102078@csu.edu.cn.

Yao Liu (Y)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: 198102082@csu.edu.cn.

Chunhui Li (C)

Center for Healthcare-associated Infection Control, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: lichunhui_d@126.com.

Wenting Peng (W)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: pengwenting_123@163.com.

Chuan Jiang (C)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: jiangchuan1998@163.com.

Shifang Peng (S)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: sfp1988@csu.edu.cn.

Lei Fu (L)

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: fulei92@126.com.

Classifications MeSH