Efficacy and safety of oral probiotic supplementation in mitigating postoperative surgical site infections in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis.
colorectal cancer surgery
meta-analysis
probiotic supplementation
surgical site infections
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
28 Dec 2023
28 Dec 2023
Historique:
revised:
09
12
2023
received:
02
11
2023
accepted:
10
12
2023
medline:
29
12
2023
pubmed:
29
12
2023
entrez:
28
12
2023
Statut:
aheadofprint
Résumé
Surgical site infections (SSIs) pose significant risks to patients undergoing colorectal cancer (CRC) surgery. With increasing evidence on the benefits of oral probiotics in various clinical contexts, there is a need to assess their efficacy and safety in reducing SSIs following CRC surgery. A systematic review and meta-analysis were conducted in line with PRISMA guidelines using the PICO framework. On 19 September 2023, four major databases (PubMed, Embase, Web of Science and Cochrane Library) were searched without any temporal or language restrictions. Rigorous inclusion and exclusion criteria were employed. Data extraction was independently undertaken by two assessors, and any discrepancies were discussed. The Cochrane Collaboration's risk of bias instrument was utilized to assess study quality. The meta-analysis incorporated a fixed-effects model or random-effects model based on the I2 statistic to assess heterogeneity. The initial search yielded 1282 articles, of which 10 met the inclusion criteria and were analysed. Probiotic administration not only significantly reduced the incidence of SSIs but also curtailed the duration of hospital stays. Moreover, the subgroup analysis indicated that interventions employing multiple strains of probiotics were more effective in reducing postoperative infections than those utilizing a single strain. Probiotics effectively prevent postoperative infections and shorten hospital stays. Multi-strain probiotics outperform single strain in efficacy. Future studies should focus on their safety and optimal clinical use.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82071374
Organisme : Discipline Construction Project of Guangdong Medical University
ID : 1.13
Organisme : Dongguan Science and Technology of Social Development Program
ID : 20221800905682
Organisme : Talent Development Foundation of The First Dongguan Affiliated Hospital of Guangdong Medical University
ID : PF100-1-04
Organisme : Talent Development Foundation of The First Dongguan Affiliated Hospital of Guangdong Medical University
ID : PF100-1-01
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : ZYDS002
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : ZZDC001
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : FZDB005
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : ZZDI001
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : ZYDB016
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : ZCDS001
Organisme : College Students Innovative Experimental Project in Guangdong Medical University
ID : FYDB015
Organisme : College Students' Science and Technology Innovation Training Project
ID : S202210571097
Organisme : College Students' Science and Technology Innovation Training Project
ID : S202210571087
Organisme : College Students' Science and Technology Innovation Training Project
ID : 202 210 571 030
Organisme : College Students' Science and Technology Innovation Training Project
ID : 202210571025
Organisme : Guangdong Medical Science and Technology Research Fund Program
ID : A2020353
Informations de copyright
© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
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