GABA

Alzheimer’s disease GABA-mimetics GABAA receptor homotaurine inflammation taurine tramiprosate

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2023
Historique:
received: 01 08 2023
accepted: 20 11 2023
medline: 29 12 2023
pubmed: 29 12 2023
entrez: 29 12 2023
Statut: epublish

Résumé

Dementia and autoimmune diseases are prevalent conditions with limited treatment options. Taurine and homotaurine (HT) are naturally occurring sulfonate amino acids, with taurine being highly abundant in animal tissues, but declining with age in the blood. HT is a blood-brain barrier permeable drug under investigation for Alzheimer's disease. HT also has beneficial effects in a mouse model of multiple sclerosis likely through an anti-inflammatory mechanism mediated by GABA

Identifiants

DOI: 10.3389/fphar.2023.1271203 PMID: 38155909 PMC: PMC10752957
pubmed: 38155909
doi: 10.3389/fphar.2023.1271203
pii: 1271203
pmc: PMC10752957
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1271203

Informations de copyright

Copyright © 2023 Meera, Uusi-Oukari, Lipshutz and Wallner.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Pratap Meera (P)

Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, United States.

Mikko Uusi-Oukari (M)

Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Gerald S Lipshutz (GS)

Department of Surgery, University of California, Los Angeles, Los Angeles, CA, United States.
Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.
Intellectual and Developmental Disabilities Research Center, University of California, Los Angeles, Los Angeles, CA, United States.
Semel Institute for Neuroscience, University of California, Los Angeles, Los Angeles, CA, United States.

Martin Wallner (M)

Department of Surgery, University of California, Los Angeles, Los Angeles, CA, United States.

Classifications MeSH