Cerebral and systemic near infrared spectroscopy patterns in preterm infants treated by caffeine.
NIRS
brain
kidney
preterm
splanchnic
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
29 Dec 2023
29 Dec 2023
Historique:
revised:
22
11
2023
received:
17
09
2023
accepted:
14
12
2023
medline:
29
12
2023
pubmed:
29
12
2023
entrez:
29
12
2023
Statut:
aheadofprint
Résumé
To investigate the effects of caffeine loading/maintenance administration on near-infrared spectroscopy cerebral, kidney and splanchnic patterns in preterm infants. We conducted a multicentre case-control prospective study in 40 preterm infants (gestational age 29 ± 2 weeks) where each case acted as its own control. A caffeine loading dose of 20 mg/kg and a maintenance dose of 5 mg/kg after 24 h were administered intravenously. Near infrared spectroscopy monitoring parameters were monitored 30 min before, 30 min during and 180 min after caffeine therapy administration. A significant increase (p < 0.05) in splanchnic regional oxygenation and tissue function and a decrease (p < 0.05) in cerebral tissue function after loading dose was shown. A preferential hemodynamic redistribution from cerebral to splanchnic bloodstream was also observed. After caffeine maintenance dose regional oxygenation did not change in the monitored districts, while tissue function increased in kidney and splanchnic bloodstream. Different caffeine administration modalities affect cerebral/systemic oxygenation status, tissue function and hemodynamic pattern in preterm infants. Future studies correlating near infrared spectroscopy parameters and caffeine therapy are needed to determine the short/long-term effect of caffeine in preterm infants.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : L'insieme
Organisme : I colori della vita foundation
Informations de copyright
© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Références
Walani SR. Global burden of preterm birth. Int J Gynaecol Obstet. 2020;150:31-33.
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75-84.
Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. Outcomes for extremely premature infants. Anesth Analg. 2015;120:1337-1351.
Dobson NR, Hunt CE. Caffeine use in neonates: indications, pharmacokinetics, clinical effects, outcomes. Neoreviews. 2013;14:540-550.
Kreutzer K, Bassler D. Caffeine for apnea of prematurity: a neonatal success story. Neonatology. 2014;105:332-336.
Shepherd E, Salam RA, Middleton P, et al. Neonatal interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2018;6:CD012409.
Henderson-Smart DJ, De Paoli AG. Methylxanthine treatment for apnea in preterm infants. Cochrane Database Syst Rev. 2010;12:CD000140.
Erenberg A, Leff RD, Haack DG, et al. Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebo-controlled study. Pharmacotherapy. 2000;20:644-652.
Rhein LM, Dobson NR, Darnall RA, et al. Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial. JAMA Pediatr. 2014;168:250-257.
Mayer CA, Haxhiu MA, Martin RJ, Wilson CG. Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats. J Appl Physiol. 1985;100:91-97.
Wilson CG, Martin RJ, Jaber M, et al. Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets. Respir Physiol Neurobiol. 2004;141:201-211.
Bhatt-Mehta V, Schumacher RE. Treatment of apnea of prematurity. Paediatr Drugs. 2003;5:195-210.
Schmidt B, Roberts RS, Davis P, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357:1893-1902.
Nylander Vujovic S, Nava C, Johansson M, Bruschettini M. Confounding biases in studies on early- versus late-caffeine in preterm infants: a systematic review. Pediatr Res. 2020;88:357-364.
Hunter CL, Oei JL, Suzuki K, Lui K, Schindler T. Patterns of use of near-infrared spectroscopy in neonatal intensive care units: international usage survey. Acta Paediatr. 2018;107:1198-1204.
Dani C, Bertini G, Reali MF, et al. Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment. Biol Neonate. 2000;78:27-32.
Ilhan O, Bor M. Effects of single loading dose of intravenous caffeine on cerebral oxygenation in preterm infants. Am J Perinatol. 2021;38:116-122.
Ilhan O, Bor M. Effects of caffeine on splanchnic oxygenation in preterm infants. Am J Perinatol. 2021;38:1062-1069.
Harer MW, Rothwell AC, Richard LJ, Adegboro CO, McAdams RM. Renal tissue oxygenation after caffeine administration in preterm neonates. Pediatr Res. 2021;90:1171-1176.
Grometto A, Pizzo B, Strozzi MC, Gazzolo F, Gazzolo D. Near-infrared spectroscopy is a promising noninvasive technique for monitoring the effects of feeding regimens on the cerebral and splanchnic regions. Acta Paediatr. 2018;107:234-239.
Grometto A, Pizzo B, Strozzi MC, Gazzolo F, Gazzolo D. Cerebral NIRS patterns in late preterm and very preterm infants becoming late preterm. J Matern Fetal Neonatal Med. 2019;32:1124-1129.
Dani C, Coviello C, Montano S, et al. Effect on splanchnic oxygenation of breast milk, fortified breast milk, and formula milk in preterm infants. Pediatr Res. 2021;89:171-174.
Vesoulis ZA, Mintzer JP, Chock VY. Neonatal NIRS monitoring: recommendations for data capture and review of analytics. J Perinatol. 2021;41:675-688.
Prechtl HFR. Assessment methods for the newborn infant, a critical evaluation. In: Stratton P, ed. Psychobiology of the Human Newborn. Wiley; 1982:21-52.
Jurgens-van der Zee AD, Bierman-van Eendenburg MEC, Fidler VJ, et al. Preterm birth, growth retardation and acidemia in relation to neurological abnormality of the newborn. Early Hum Dev. 1979;3:141-154.
Sweet DG, Carnielli VP, Greisen G, et al. European consensus guidelines on the Management of Respiratory Distress Syndrome: 2022 update. Neonatology. 2023;120:3-23.
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529-534.
Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723-1729.
Agarwal K, Jalali S. Classification of retinopathy of prematurity: from then till now. Community Eye Health. 2018;31:S4-S7.
Dix LML, van Bel F, Baerts W, Lemmers PMA. Effects of caffeine on the preterm brain: an observational study. Early Hum Dev. 2018;120:17-20.
Hoffman SG, Lakhani A, Viscardi RM. The association between carbon dioxide, cerebral blood flow, and autoregulation in the premature infant. J Perinatol. 2021;41:324-329.
Jayasinghe D, Ab G, Mi L. CBF reactivity in hypotensive and normotensive preterm infants. Pediatr Res. 2003;54:848-853.
Hoecker C, Nelle M, Beedgen B, Rengelshausen J, Linderkamp O. Effects of a divided high loading dose of caffeine on circulatory variables in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2006;91:F61-F64.
Soraisham AS, Elliott D, Amin H. Effect of single loading dose of intravenous caffeine infusion on superior mesenteric artery blood flow velocities in preterm infants. J Paediatr Child Health. 2008;44:119-121.
Lane AJ, Coombs RC, Evans DH, Levin RJ. Effect of caffeine on neonatal splanchnic blood flow. Arch Dis Child Fetal Neonatal. 1999;80:F128-F129.
Hoecker C, Nelle M, Poeschl J, Beedgen B, Linderkamp O. Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics. 2002;109:784-787.
McNeill S, Gatenby JC, McElroy S, Engelhardt B. Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infants. J Perinatol. 2011;31:51-57.