Tensor-valued diffusion MRI of human acute stroke.
Monte Carlo diffusion simulation
b-tensor
diffusion time
neurite beading
stroke
tensor-valued diffusion encoding
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
revised:
18
11
2023
received:
08
08
2023
accepted:
27
11
2023
pubmed:
2
1
2024
medline:
2
1
2024
entrez:
29
12
2023
Statut:
ppublish
Résumé
Tensor-valued diffusion encoding can disentangle orientation dispersion and subvoxel anisotropy, potentially offering insight into microstructural changes after cerebral ischemia. The purpose was to evaluate tensor-valued diffusion MRI in human acute ischemic stroke, assess potential confounders from diffusion time dependencies, and compare to Monte Carlo diffusion simulations of axon beading. Linear (LTE) and spherical (STE) b-tensor encoding with inherently different effective diffusion times were acquired in 21 acute ischemic stroke patients between 3 and 57 h post-onset at 3 T in 2.5 min. In an additional 10 patients, STE with 2 LTE yielding different effective diffusion times were acquired for comparison. Diffusional variance decomposition (DIVIDE) was used to estimate microscopic anisotropy (μFA), as well as anisotropic, isotropic, and total diffusional variance (MK MD was ˜40% lower in lesions for all LTE/STE protocols. The DIVIDE parameters varied with effective diffusion time: higher μFA and MK DIVIDE parameters depend on diffusion time in acute stroke but consistently indicate neurite beading and larger intracellular volume fraction.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2126-2141Subventions
Organisme : Canada Research Chairs program
Organisme : China Scholarship Council
Organisme : Heart and Stroke Foundation of Canada
Informations de copyright
© 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
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