Dietary Intake of Fructooligosaccharides Protects against Metabolic Derangements Evoked by Chronic Exposure to Fructose or Galactose in Rats.
advanced glycation end-products
blood lipids
cytokines
inflammation
liver lipid accumulation
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
29 Dec 2023
29 Dec 2023
Historique:
medline:
2
1
2024
pubmed:
2
1
2024
entrez:
29
12
2023
Statut:
aheadofprint
Résumé
Diets rich in fat and sugars evoke chronic low-grade inflammation, leading to metabolic derangements. This study investigates the impact of fructose and galactose, two commonly consumed simple sugars, on exacerbation of the harmful effects caused by high fat intake. Additionally, the potential efficacy of fructooligosaccharides (FOS), a fermentable dietary fiber, in counteracting these effects is examined. Male Sprague-Dawley rats (six/group) are fed 8 weeks as follows: control 5% fat diet (CNT), 20% fat diet (FAT), FAT+10% FOS diet (FAT+FOS), FAT+25% galactose diet (FAT+GAL), FAT+GAL+10% FOS diet (FAT+GAL+FOS), FAT+25% fructose diet (FAT+FRU), FAT+FRU+10% FOS diet (FAT+FRU+FOS). The dietary manipulations tested do not affect body weight gain, blood glucose, or markers of systemic inflammation whereas significant increases in plasma concentrations of triacylglycerols, cholesterol, aspartate aminotransferase, and alanine aminotrasferase are detected in both FAT+FRU and FAT+GAL compared to CNT. In the liver and skeletal muscle, both sugars induce significant accumulation of lipids and advanced glycation end-products (AGEs). FOS supplementation prevents these impairments. This study extends the understanding of the deleterious effects of a chronic intake of simple sugars and demonstrates the beneficial role of the prebiotic FOS in dampening the sugar-induced metabolic impairments by prevention of lipid and AGEs accumulation.
Identifiants
pubmed: 38158337
doi: 10.1002/mnfr.202300476
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300476Subventions
Organisme : Ministero delle Politiche Agricole Alimentari e Forestali
ID : 1170 - Carb-Q-4- Health
Organisme : German Federal Ministry of Education and Research
ID : 01EA1907
Organisme : Swedish Research Council for Sustainable Development
Organisme : CarbQ4Health
Organisme : European Joint Programming Initiative
ID : 2019-02201
Organisme : ERA-NET Cofund HDHL INTIMIC
ID : GA N° 727565
Organisme : EU Horizon 2020 Research and Innovation Programme
Informations de copyright
© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
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