Metastatic potentials classified with hypoxia-inducible factor 1 downstream genes in pan-cancer cell lines.
HIF1
cancer cell line
hierarchical clustering
metastatic potential
Journal
Genes to cells : devoted to molecular & cellular mechanisms
ISSN: 1365-2443
Titre abrégé: Genes Cells
Pays: England
ID NLM: 9607379
Informations de publication
Date de publication:
29 Dec 2023
29 Dec 2023
Historique:
revised:
17
12
2023
received:
20
06
2023
accepted:
20
12
2023
medline:
2
1
2024
pubmed:
2
1
2024
entrez:
30
12
2023
Statut:
aheadofprint
Résumé
Hypoxia-inducible factor 1 (HIF1) is a transcription factor that is stabilized under hypoxia conditions via post-translational modifications. HIF1 regulates tumor malignancy and metastasis by gene transcriptions, such as Warburg effect and angiogenesis-related genes, in cancer cells. However, the HIF1 downstream genes show varied expressional patterns in different cancer types. Herein, we performed the hierarchical clustering based on the HIF1 downstream gene expression patterns using 1406 cancer cell lines crossing 30 types of cancer to understand the relationship between HIF1 downstream genes and the metastatic potential of cancer cell lines. Two types of cancers, including bone and breast cancers, were classified based on HIF1 downstream genes with significantly altered metastatic potentials. Furthermore, different HIF1 downstream gene subsets were extracted to discriminate each subtype for these cancer types. HIF1 downstream subtyping classification will help to understand the novel insight into tumor malignancy and metastasis in each cancer type.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fukushima Prefecture
Organisme : Japan Society for the Promotion of Science
ID : JP21K15562
Organisme : Japan Society for the Promotion of Science
ID : JP23K06665
Informations de copyright
© 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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