Neural correlates of episodic memory decline following electroconvulsive therapy: An exploratory functional magnetic resonance imaging study.
ECT
cognitive side effects
electroconvulsive therapy
memory
neural
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
30 Dec 2023
30 Dec 2023
Historique:
medline:
2
1
2024
pubmed:
2
1
2024
entrez:
30
12
2023
Statut:
aheadofprint
Résumé
Electroconvulsive therapy (ECT) is an efficient and rapid-acting treatment indicated for severe depressive disorders. While ECT is commonly accompanied by transient memory decline, the brain mechanisms underlying these side effects remain unclear. In this exploratory functional magnetic resonance (fMRI) study, we aimed to compare effects of ECT versus pharmacological treatment on neural response during episodic memory encoding in patients with affective disorders. This study included 32 ECT-treated patients (major depressive disorder (MDD), Groups were comparable on age, gender, and educational years ( Episodic memory decline was related to greater neural activity in the left PCG, but unrelated to increased dmPFC and MFG activity, immediately after ECT.
Sections du résumé
BACKGROUND
UNASSIGNED
Electroconvulsive therapy (ECT) is an efficient and rapid-acting treatment indicated for severe depressive disorders. While ECT is commonly accompanied by transient memory decline, the brain mechanisms underlying these side effects remain unclear.
AIMS
UNASSIGNED
In this exploratory functional magnetic resonance (fMRI) study, we aimed to compare effects of ECT versus pharmacological treatment on neural response during episodic memory encoding in patients with affective disorders.
METHODS
UNASSIGNED
This study included 32 ECT-treated patients (major depressive disorder (MDD),
RESULTS
UNASSIGNED
Groups were comparable on age, gender, and educational years (
CONCLUSIONS
UNASSIGNED
Episodic memory decline was related to greater neural activity in the left PCG, but unrelated to increased dmPFC and MFG activity, immediately after ECT.
Identifiants
pubmed: 38159102
doi: 10.1177/02698811231221153
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2698811231221153Déclaration de conflit d'intérêts
Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: JZP has within the last 3 years received honoraria from Lundbeck Pharma A/S. LVK has within the last 3 years been a consultant for Lundbeck and Teva. KWM has received consultancy fees from Lundbeck, Janssen, Angelini Pharma and Richter Gedeon in the past 3 years. JMAC, ATYN, and MBJ report no conflicts of interest.