Circulating Oxidized mtDNA is Associated Broadly with Cardiovascular Disease in a Longitudinal Cohort Study of Psoriasis.
Cardiovascular disease
IL-17 signaling in psoriasis
Oxidized mtDNA
Journal
JID innovations : skin science from molecules to population health
ISSN: 2667-0267
Titre abrégé: JID Innov
Pays: Netherlands
ID NLM: 101776173
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
05
04
2023
revised:
19
10
2023
accepted:
20
10
2023
medline:
2
1
2024
pubmed:
2
1
2024
entrez:
1
1
2024
Statut:
epublish
Résumé
Psoriasis (PSO) is a chronic and systemic inflammatory autoimmune disease associated with atherosclerosis and myocardial infarction. Given that atherosclerosis is both inflammation and immune driven, we sought to expand on known immune and inflammatory biomarkers in a PSO cohort. In this study, we focus on oxidized mtDNA (ox-mtDNA), a product of cells undergoing pyroptosis, including keratinocytes, which was quantified in patients with PSO and individuals without PSO by ELISA. Patients with PSO had significantly higher ox-mtDNA levels than healthy subjects (mean ± SD = 9246 ± 2518 pg/ml for patients with PSO vs 7382 ± 2506 pg/ml for those without;
Identifiants
pubmed: 38162017
doi: 10.1016/j.xjidi.2023.100243
pii: S2667-0267(23)00069-3
pmc: PMC10755835
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100243Informations de copyright
© 2023 The Authors. Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.