Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.

Immunology Microbiology Transcriptomics Virology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
15 Dec 2023
Historique:
received: 25 08 2023
revised: 16 10 2023
accepted: 21 11 2023
medline: 2 1 2024
pubmed: 2 1 2024
entrez: 1 1 2024
Statut: epublish

Résumé

The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells. We addressed the function of the inositol-requiring enzyme 1 (IRE1) signaling branch of the UPR in NK cells in homeostasis and microbial challenge. Cell-intrinsic compound deficiency of IRE1 and its downstream transcription factor XBP1 in NKp46

Identifiants

DOI: 10.1016/j.isci.2023.108570 PMID: 38162021 PMC: PMC10755724
pubmed: 38162021
doi: 10.1016/j.isci.2023.108570
pii: S2589-0042(23)02647-0
pmc: PMC10755724
doi:

Types de publication

Journal Article

Langues

eng

Pagination

108570

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

E.V. is a cofounder and employee of Innate Pharma. All other authors declare no competing interests.

Auteurs

Jessica Vetters (J)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Mary van Helden (M)

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Byondis B.V., Nijmegen, the Netherlands.

Clint De Nolf (C)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Barriers in Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Sofie Rennen (S)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Eva Cloots (E)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Evelien Van De Velde (E)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Farzaneh Fayazpour (F)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Justine Van Moorleghem (J)

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.

Manon Vanheerswynghels (M)

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.

Karl Vergote (K)

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.

Louis Boon (L)

JJP Biologics, Warsaw, Poland.

Eric Vivier (E)

Aix Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
AP-HM, Hôpital de la Timone, Marseille-Immunopôle, Marseille, France.
Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.

Bart N Lambrecht (BN)

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Laboratory for Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Pulmonary Medicine, Erasmus MC, Rotterdam, the Netherlands.

Sophie Janssens (S)

Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Classifications MeSH