Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation.
adrenoleukodystrophy
antigen presentation
immune response
inflammation
microglia
peroxisome
phagocytosis
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
09
2023
accepted:
23
11
2023
medline:
2
1
2024
pubmed:
2
1
2024
entrez:
2
1
2024
Statut:
epublish
Résumé
Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked adrenoleukodystrophy (X-ALD), a neuroinflammatory disorder, very long-chain fatty acid (VLCFA) accumulation due to impaired degradation within peroxisomes results in microglial defects, but the underlying mechanisms remain unclear. Using CRISPR/Cas9 gene editing of key genes in peroxisomal VLCFA breakdown (
Identifiants
pubmed: 38164407
doi: 10.3389/fnmol.2023.1299314
pmc: PMC10757945
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1299314Informations de copyright
Copyright © 2023 Tawbeh, Raas, Tahri-Joutey, Keime, Kaiser, Trompier, Nasser, Bellanger, Dessard, Hamon, Benani, Di Cara, Cunha Alves, Berger, Weinhofer, Mandard, Cherkaoui-Malki, Andreoletti, Gondcaille and Savary.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.