Effects of a prebiotic formulation on the composition of the faecal microbiota of people with functional constipation.
Functional constipation
Functional diversity
Functional richness
Gut microbiota
LMER models
Prebiotics
RCT
Shannon diversity
Species richness
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
10
10
2023
accepted:
28
11
2023
pubmed:
2
1
2024
medline:
2
1
2024
entrez:
2
1
2024
Statut:
ppublish
Résumé
Prebiotics are defined as substances which selectively promote beneficial gut microbes leading to a health benefit for the host. Limited trials have been carried out investigating their effect on the microbiota composition of individuals afflicted by functional constipation with equivocal outcomes. In a 21-day randomised, controlled clinical trial involving 61 adults with functional constipation, a prebiotic formulation with partially hydrolysed guar gum and acacia gum as its main ingredients, significantly increased complete spontaneous bowel motions in the treatment group. This follow-up exploratory analysis investigated whether the prebiotic was associated with changes to the composition, richness, and diversity of the faecal microbiota. Participants provided a faecal specimen at baseline and on day 21 of the intervention period. Whole genome metagenomic shotgun sequencing comprehensively assessed taxonomic and functional composition of the microbiota. Linear mixed effects regression models adjusted for potential confounders showed a significant reduction in species richness of 28.15 species (95% CI - 49.86, - 6.43) and Shannon diversity of 0.29 units (95% CI - 0.56, - 0.02) over the trial period in the prebiotic group. These changes were not observed in the control group, and functional composition was unchanged in both groups. In adults with functional constipation, the intake of a prebiotic formulation was associated with a decline of species richness and Shannon diversity. Further research regarding the associations between prebiotics and the composition and function of the gut microbiota is warranted.
Identifiants
pubmed: 38165420
doi: 10.1007/s00394-023-03292-9
pii: 10.1007/s00394-023-03292-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
777-784Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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