First report of Acinetobacter pittii acute community-acquired pneumonia in an immunocompetent patient in France following a heat wave.
Acinetobacter calcoaceticus-baumannii complex
Acinetobacter pittii
Community-acquired pneumonia
Emerging infectious diseases
Global warming
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
02 Jan 2024
02 Jan 2024
Historique:
received:
23
08
2023
accepted:
22
12
2023
medline:
4
1
2024
pubmed:
4
1
2024
entrez:
3
1
2024
Statut:
epublish
Résumé
In recent years, Acinetobacter baumannii-calcoaceticus complex (ABC) infections have attracted attention, mainly because of the impact of carbapenem-resistant isolates in hospital-acquired infections. However, acute community-acquired ABC infections are not uncommon in warm and humid countries, where they are responsible for community-acquired infections with specific clinical features. To date, such infection has not been reported in France. We report the case of a 55-year-old non-immunocompromised patient living in France with no known risk factors for community-acquired ABC infections who presented pneumonia with bloodstream infection due to wild-type A. pittii. The outcome was favorable after 7 days of antibiotic treatment with cefepime. We confirmed bacterial identification with whole-genome sequencing, and we examined the A. pitii core-genome phylogeny for genomic clusters. This situation is uncommon in Europe and occurred after a heat wave in France with temperatures above 38 °C. Herein, we discuss the possibility that this pneumonia may be emerging in the current context of global warming.
Sections du résumé
BACKGROUND
BACKGROUND
In recent years, Acinetobacter baumannii-calcoaceticus complex (ABC) infections have attracted attention, mainly because of the impact of carbapenem-resistant isolates in hospital-acquired infections. However, acute community-acquired ABC infections are not uncommon in warm and humid countries, where they are responsible for community-acquired infections with specific clinical features. To date, such infection has not been reported in France.
CASE PRESENTATION
METHODS
We report the case of a 55-year-old non-immunocompromised patient living in France with no known risk factors for community-acquired ABC infections who presented pneumonia with bloodstream infection due to wild-type A. pittii. The outcome was favorable after 7 days of antibiotic treatment with cefepime. We confirmed bacterial identification with whole-genome sequencing, and we examined the A. pitii core-genome phylogeny for genomic clusters.
CONCLUSIONS
CONCLUSIONS
This situation is uncommon in Europe and occurred after a heat wave in France with temperatures above 38 °C. Herein, we discuss the possibility that this pneumonia may be emerging in the current context of global warming.
Identifiants
pubmed: 38166743
doi: 10.1186/s12879-023-08945-y
pii: 10.1186/s12879-023-08945-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Informations de copyright
© 2024. The Author(s).
Références
Almeida LA, Araujo R. Highlights on molecular identification of closely related species. Infect Genet Evol. 2013;13:67–75.
doi: 10.1016/j.meegid.2012.08.011
pubmed: 22982158
Eveillard M, Kempf M, Belmonte O, Pailhoriès H, Joly-Guillou ML. Reservoirs of Acinetobacter baumannii outside the hospital and potential involvement in emerging human community-acquired Infections. Int J Infect Dis. 2013;17(10):e802–805.
doi: 10.1016/j.ijid.2013.03.021
pubmed: 23672981
Ibrahim S, Al-Saryi N, Al-Kadmy IMS, Aziz SN. Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals. Mol Biol Rep. 2021;48(10):6987–98.
doi: 10.1007/s11033-021-06690-6
pubmed: 34460060
pmcid: 8403534
Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and Tuberculosis. Lancet Infect Dis. 2018;18(3):318–27.
doi: 10.1016/S1473-3099(17)30753-3
pubmed: 29276051
Chusri S, Chongsuvivatwong V, Rivera JI, Silpapojakul K, Singkhamanan K, McNeil E, et al. Clinical outcomes of hospital-acquired Infection with Acinetobacter nosocomialis and Acinetobacter pittii. Antimicrob Agents Chemother. 2014;58(7):4172–9.
doi: 10.1128/AAC.02992-14
pubmed: 24820079
pmcid: 4068534
Gaynes R, Edwards JR, National Nosocomial Infections Surveillance System. Overview of nosocomial Infections caused by gram-negative bacilli. Clin Infect Dis. 2005;41(6):848–54.
doi: 10.1086/432803
pubmed: 16107985
Asai N, Sakanashi D, Suematsu H, Kato H, Watanabe H, Shiota A, et al. Clinical manifestations and risk factors of community-onset Acinetobacter species Pneumonia in Japan; case control study in a single institute in Japan. J Infect Chemother. 2019;25(8):639–42.
doi: 10.1016/j.jiac.2019.03.016
pubmed: 31053537
Chen MZ, Hsueh PR, Lee LN, Yu CJ, Yang PC, Luh KT. Severe community-acquired Pneumonia due to Acinetobacter baumannii. Chest. 2001;120(4):1072–7.
doi: 10.1378/chest.120.4.1072
pubmed: 11591541
Leung WS, Chu CM, Tsang KY, Lo FH, Lo KF, Ho PL. Fulminant community-acquired Acinetobacter baumannii Pneumonia as a distinct clinical syndrome. Chest. 2006;129(1):102–9.
doi: 10.1378/chest.129.1.102
pubmed: 16424419
Prjibelski A, Antipov D, Meleshko D, Lapidus A, Korobeynikov A. Using SPAdes De Novo Assembler. Curr Protoc Bioinformatics. 2020;70(1):e102.
doi: 10.1002/cpbi.102
pubmed: 32559359
Clausen PTLC, Aarestrup FM, Lund O. Rapid and precise alignment of raw reads against redundant databases with KMA. BMC Bioinformatics. 2018;19(1):307.
doi: 10.1186/s12859-018-2336-6
pubmed: 30157759
pmcid: 6116485
Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020;75(12):3491–500.
doi: 10.1093/jac/dkaa345
pubmed: 32780112
pmcid: 7662176
Page AJ, Cummins CA, Hunt M, Wong VK, Reuter S, Holden MTG, et al. Roary: rapid large-scale prokaryote pan genome analysis. Bioinformatics. 2015;31(22):3691–3.
doi: 10.1093/bioinformatics/btv421
pubmed: 26198102
pmcid: 4817141
Guindon S, Dufayard JF, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59(3):307–21.
doi: 10.1093/sysbio/syq010
pubmed: 20525638
Ong CWM, Lye DCB, Khoo KL, Chua GSW, Yeoh SF, Leo YS, et al. Severe community-acquired Acinetobacter baumannii Pneumonia: an emerging highly lethal Infectious Disease in the Asia–Pacific. Respirology. 2009;14(8):1200–5.
doi: 10.1111/j.1440-1843.2009.01630.x
pubmed: 19909464
Larcher R, Pantel A, Arnaud E, Sotto A, Lavigne JP. First report of cavitary Pneumonia due to community-acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment. BMC Infect Dis. 2017;17(1):477.
doi: 10.1186/s12879-017-2589-0
pubmed: 28683724
pmcid: 5500973
Falagas ME, Karveli EA, Kelesidis I, Kelesidis T. Community-acquired Acinetobacter Infections. Eur J Clin Microbiol Infect Dis. 2007;26(12):857–68.
doi: 10.1007/s10096-007-0365-6
pubmed: 17701432
Davis JS, McMillan M, Swaminathan A, Kelly JA, Piera KE, Baird RW, et al. A 16-year prospective study of community-onset bacteremic Acinetobacter Pneumonia: low mortality with appropriate initial empirical antibiotic protocols. Chest. 2014;146(4):1038–45.
doi: 10.1378/chest.13-3065
pubmed: 24901292
En France, des vagues de chaleur plus intenses et fréquentes [Internet]. 2022 [cited 2023 Jun 4]. Available from: https://www.linfodurable.fr/en-france-des-vagues-de-chaleur-plus-intenses-et-frequentes-35414 .
Baker RE, Mahmud AS, Miller IF, Rajeev M, Rasambainarivo F, Rice BL, et al. Infectious Disease in an era of global change. Nat Rev Microbiol. 2022;20(4):193–205.
doi: 10.1038/s41579-021-00639-z
pubmed: 34646006
Mahmud AS, Martinez PP, He J, Baker RE. The impact of Climate Change on Vaccine-Preventable Diseases: insights from current research and new directions. Curr Environ Health Rep. 2020;7(4):384–91.
doi: 10.1007/s40572-020-00293-2
pubmed: 33099754
pmcid: 7585557
Martinez-Urtaza J, van Aerle R, Abanto M, Haendiges J, Myers RA, Trinanes J, et al. Genomic variation and evolution of Vibrio parahaemolyticus ST36 over the course of a Transcontinental Epidemic Expansion. mBio. 2017;8(6):e01425–17.
doi: 10.1128/mBio.01425-17
pubmed: 29138301
pmcid: 5686534
Abanto M, Gavilan RG, Baker-Austin C, Gonzalez-Escalona N, Martinez-Urtaza J. Global expansion of Pacific Northwest Vibrio parahaemolyticus sequence type 36. Emerg Infect Dis. 2020;26(2):323–6.
doi: 10.3201/eid2602.190362
pubmed: 31961301
pmcid: 6986845
Couper LI, MacDonald AJ, Mordecai EA. Impact of prior and projected climate change on US Lyme Disease incidence. Glob Chang Biol. 2021;27(4):738–54.
doi: 10.1111/gcb.15435
pubmed: 33150704