Pharmacokinetic Profiles of a New Extended-release Buprenorphine Formulation in Cynomolgus Macaques (

Journal

Journal of the American Association for Laboratory Animal Science : JAALAS
ISSN: 2769-6677
Titre abrégé: J Am Assoc Lab Anim Sci
Pays: United States
ID NLM: 101269489

Informations de publication

Date de publication:
02 Jan 2024
Historique:
medline: 4 1 2024
pubmed: 4 1 2024
entrez: 3 1 2024
Statut: aheadofprint

Résumé

The primary objective of this study was to evaluate the pharmacokinetic profile of a new extended-release formulation of buprenorphine (BupBaseER) at a dose that would produce pain management of the desired duration. A secondary objective was to compare the incidence of injection site reactions between the original extended-release formulation (BupHClER) and BupBaseER, which uses a different proprietary polymer-based vehicle than does the BupHClER formulation. Eighteen cynomolgus macaques (

Identifiants

DOI: 10.30802/AALAS-JAALAS-23-000037 PMID: 38167263
pubmed: 38167263
doi: 10.30802/AALAS-JAALAS-23-000037
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Dania I Del Castillo-Pratts (DID)

Charles River Laboratories, NHP Import and Quarantine Site, Frederick, Maryland.

Clint Rosenfeld (C)

Charles River Laboratories, Department of Pharmacokinetics and Biostatistics, Mattawan, Michigan.

Stephen Kirschner (S)

Wildlife Pharmaceuticals, Clinical Research and Development, Fort Collins, Colorado.

Elizabeth Nunamaker (E)

Charles River Laboratories, Animal Welfare and Training, Wilmington, Massachusetts.

David Reim (D)

Charles River Laboratories, Laboratory Animal Medicine, Reno, Nevada; and.

Cassondra Bauer (C)

Charles River Laboratories, Laboratory Animal Medicine, Ashland, Ohio.

Classifications MeSH