A Mendelian randomization study on the effects of plasma lipids on irritable bowel syndrome and functional dyspepsia.

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 Jan 2024
Historique:
received: 14 07 2023
accepted: 20 12 2023
medline: 4 1 2024
pubmed: 4 1 2024
entrez: 3 1 2024
Statut: epublish

Résumé

Although functional gastrointestinal disorder (FGID) is a common clinical condition, its risk factors remain unclear. We performed a Mendelian randomization study to explore the association between plasma lipids and the risk of FGID. Instrumental variables closely related to six plasma lipids were obtained from the corresponding genome-wide association studies, and summary-level data on FGID, including irritable bowel syndrome (IBS) and functional dyspepsia (FD), were extracted from the FinnGen study. The primary inverse variance weighted method and other supplementary analyses were used to evaluate the causal relationship between diverse plasma lipids and FGID. For each increase in the standard deviation of triglyceride levels, there was a 12.0% increase in the risk of IBS rather than that of FD. Low- and high-density lipoprotein cholesterol, total cholesterol, apolipoprotein A, and apolipoprotein B levels were not associated with the risk of IBS or FD. Through this study, we identified the causal role of triglycerides in the pathogenesis of IBS, which could benefit further basic and clinical research.

Identifiants

DOI: 10.1038/s41598-023-50459-9 PMID: 38167458
pubmed: 38167458
doi: 10.1038/s41598-023-50459-9
pii: 10.1038/s41598-023-50459-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

78

Subventions

Organisme : National Natural Science Foundation of China
ID : 82070547

Informations de copyright

© 2024. The Author(s).

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Auteurs

Mengmeng Xu (M)

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, Changsha, 410007, China.
Research Center of Digestive Disease, Central South University, Changsha, China.

Deliang Liu (D)

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, Changsha, 410007, China.
Research Center of Digestive Disease, Central South University, Changsha, China.

Yuyong Tan (Y)

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, Changsha, 410007, China.
Research Center of Digestive Disease, Central South University, Changsha, China.

Jian He (J)

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Bingyi Zhou (B)

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, No.139 Renmin Middle Road, Changsha, 410007, China. zhoubingyi0508@csu.edu.cn.
Research Center of Digestive Disease, Central South University, Changsha, China. zhoubingyi0508@csu.edu.cn.

Classifications MeSH