Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer.

Glucocorticoids HSD11B1 immunotherapy renal cancer steroidogenesis

Journal

Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526

Informations de publication

Date de publication:
2024
Historique:
medline: 4 1 2024
pubmed: 4 1 2024
entrez: 3 1 2024
Statut: epublish

Résumé

Although immune-based therapies have revolutionized the management of cancer, novel approaches are urgently needed to improve their outcome. We investigated the role of endogenous steroids in the resistance to cancer immunotherapy, as these have strong immunomodulatory functions. Using a publicly available database, we found that the intratumoral expression of 11 beta-hydroxysteroid dehydrogenase type 1 (

Identifiants

DOI: 10.1080/2162402X.2023.2286820 PMID: 38170044 PMC: PMC10761155
pubmed: 38170044
doi: 10.1080/2162402X.2023.2286820
pii: 2286820
pmc: PMC10761155
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2286820

Informations de copyright

© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

Déclaration de conflit d'intérêts

No potential conflict of interest was reported by the authors.

Auteurs

Hélène Poinot (H)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0009-0006-8347-8430

Eloïse Dupuychaffray (E)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0009-0004-0465-6856

Grégoire Arnoux (G)

Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Montserrat Alvarez (M)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0001-7206-073X

Jérémie Tachet (J)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-2442-6327

Ounss Ezzar (O)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.

Jonathan Moore (J)

Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-7586-671X

Olivia Bejuy (O)

CIBM Center for Biomedical Imaging, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-6457-6717

Eulalia Olesti (E)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0001-8677-9964

Gioele Visconti (G)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0003-2486-7744

Víctor González-Ruiz (V)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0001-7204-2363

Serge Rudaz (S)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-4180-5417

Jean-Christophe Tille (JC)

Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.

Clarissa D Voegel (CD)

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
ORCID: 0000-0002-5480-7956

Patrycja Nowak-Sliwinska (P)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-8299-0444

Carole Bourquin (C)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
Department of Anesthetics, Pharmacology, Intensive Care and Emergencies, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0003-3862-4583

Aurélien Pommier (A)

School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.
ORCID: 0009-0001-6540-1863

Classifications MeSH