Regulation of genes encoding polysaccharide-degrading enzymes in Penicillium.
Molecular breeding
Penicillium oxalicum
Plant-polysaccharide-degrading enzyme
Regulatory factor
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
received:
29
06
2023
accepted:
10
10
2023
revised:
02
10
2023
medline:
4
1
2024
pubmed:
4
1
2024
entrez:
3
1
2024
Statut:
ppublish
Résumé
Penicillium fungi, including Penicillium oxalicum, can secrete a range of efficient plant-polysaccharide-degrading enzymes (PPDEs) that is very useful for sustainable bioproduction, using renewable plant biomass as feedstock. However, the low efficiency and high cost of PPDE production seriously hamper the industrialization of processes based on PPDEs. In Penicillium, the expression of PPDE genes is strictly regulated by a complex regulatory system and molecular breeding to modify this system is a promising way to improve fungal PPDE yields. In this mini-review, we present an update on recent research progress concerning PPDE distribution and function, the regulatory mechanism of PPDE biosynthesis, and molecular breeding to produce PPDE-hyperproducing Penicillium strains. This review will facilitate future development of fungal PPDE production through metabolic engineering and synthetic biology, thereby promoting PPDE industrial biorefinery applications. KEY POINTS: • This mini review summarizes PPDE distribution and function in Penicillium. • It updates progress on the regulatory mechanism of PPDE biosynthesis in Penicillium. • It updates progress on breeding of PPDE-hyperproducing Penicillium strains.
Identifiants
pubmed: 38170318
doi: 10.1007/s00253-023-12892-8
pii: 10.1007/s00253-023-12892-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-12Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Alam MA, Kamlangdee N, Kelly JM (2017) The CreB deubiquitinating enzyme does not directly target the CreA repressor protein in Aspergillus nidulans. Curr Genet 63(4):647–667. https://doi.org/10.1007/s00294-016-0666-3
doi: 10.1007/s00294-016-0666-3
pubmed: 27878624
Behera BC, Sethi BK, Mishra RR, Dutta SK, Thatoi HN (2017) Microbial cellulases—diversity & biotechnology with reference to mangrove environment: a review. J Genet Eng Biotechnol 15(1):197–210. https://doi.org/10.1016/j.jgeb.2016.12.001
doi: 10.1016/j.jgeb.2016.12.001
pubmed: 30647656
Chen Y, Dong L, Alam MA, Pardeshi L, Miao Z, Wang F, Tan K, Hynes MJ, Kelly JM, Wong KH (2021) Carbon catabolite repression governs diverse physiological processes and development in Aspergillus nidulans. mBio. 13(1):e0373421. https://doi.org/10.1128/mbio.03734-21
doi: 10.1128/mbio.03734-21
pubmed: 35164551
Cupertino FB, Virgilio S, Freitas FZ, Candido Tde S, Bertolini MC (2015) Regulation of glycogen metabolism by the CRE-1, RCO-1 and RCM-1 proteins in Neurospora crassa. The role of CRE-1 as the central transcriptional regulator. Fungal Genet Biol FG & B 77:82–94. https://doi.org/10.1016/j.fgb.2015.03.011
doi: 10.1016/j.fgb.2015.03.011
De Camargo BR, Takematsu HM, Ticona ARP, da Silva LA, Silva FL, Quirino BF, Hamann PRV, Noronha EF (2022) Penicillium polonicum a new isolate obtained from Cerrado soil as a source of carbohydrate-active enzymes produced in response to sugarcane bagasse. 3 Biotech 12(12):348. https://doi.org/10.1007/s13205-022-03405-x
doi: 10.1007/s13205-022-03405-x
pubmed: 36386566
pmcid: 9652181
Dharma Patria R, Rehman S, Vuppaladadiyam AK, Wang H, Lin CSK, Antunes E, Leu SY (2022) Bioconversion of food and lignocellulosic wastes employing sugar platform: a review of enzymatic hydrolysis and kinetics. Bioresour Technol 352:127083. https://doi.org/10.1016/j.biortech.2022.127083
doi: 10.1016/j.biortech.2022.127083
pubmed: 35364238
Fang H, Zhao R, Li C, Zhao C (2019b) Simultaneous enhancement of the beta-exo synergism and exo-exo synergism in Trichoderma reesei cellulase to increase the cellulose degrading capability. Microb Cell Fact 18(1):9. https://doi.org/10.1186/s12934-019-1060-x
doi: 10.1186/s12934-019-1060-x
pubmed: 30657063
pmcid: 6337788
Fang W, Xue S, Deng P, Zhang X, Wang X, Xiao Y, Fang Z (2019a) AmyZ1: a novel α-amylase from marine bacterium Pontibacillus sp. ZY with high activity toward raw starches. Biotechnol Biofuels 12:95. https://doi.org/10.1186/s13068-019-1432-9
doi: 10.1186/s13068-019-1432-9
pubmed: 31044008
pmcid: 6477751
Gao L, Li Z, Xia C, Qu Y, Liu M, Yang P, Yu L, Song X (2017) Combining manipulation of transcription factors and overexpression of the target genes to enhance lignocellulolytic enzyme production in Penicillium oxalicum. Biotechnol Biofuels 10:100. https://doi.org/10.1186/s13068-017-0783-3
doi: 10.1186/s13068-017-0783-3
pubmed: 28428823
pmcid: 5397729
Gao L, Xu Y, Song X, Li S, Xia C, Xu J, Qin Y, Liu G, Qu Y (2019) Deletion of the middle region of the transcription factor ClrB in Penicillium oxalicum enables cellulase production in the presence of glucose. J Biol Chem 294(49):18685–18697. https://doi.org/10.1074/jbc.RA119.010863
doi: 10.1074/jbc.RA119.010863
pubmed: 31659120
pmcid: 6901314
Gu LS, Tan MZ, Li SH, Zhang T, Zhang QQ, Li CX, Luo XM, Feng JX, Zhao S (2020) ARTP/EMS-combined multiple mutagenesis efficiently improved production of raw starch-degrading enzymes in Penicillium oxalicum and characterization of the enzyme-hyperproducing mutant. Biotechnol Biofuels 13(1):187. https://doi.org/10.1186/s13068-020-01826-5
doi: 10.1186/s13068-020-01826-5
pubmed: 33292496
pmcid: 7661180
Guo X, An Y, Liu F, Lu F, Wang B (2022) Lytic polysaccharide monooxygenase—a new driving force for lignocellulosic biomass degradation. Bioresour Technol 362:127803. https://doi.org/10.1016/j.biortech.2022.127803
doi: 10.1016/j.biortech.2022.127803
pubmed: 35995343
He QP, Zhao S, Wang JX, Li CX, Yan YS, Wang L, Liao LS, Feng JX (2018) Transcription factor NsdD regulates the expression of genes involved in plant biomass-degrading enzymes, conidiation, and pigment biosynthesis in Penicillium oxalicum. Appl Environ Microbiol 84(18):e01039–e01018. https://doi.org/10.1128/AEM.01039-18
doi: 10.1128/AEM.01039-18
pubmed: 29980558
pmcid: 6121985
He R, Ding R, Heyman JA, Zhang D, Tu R (2019) Ultra-high-throughput picoliter-droplet microfluidics screening of the industrial cellulase-producing filamentous fungus Trichoderma reesei. J Ind Microbiol Biotechnol 46(11):1603–1610. https://doi.org/10.1007/s10295-019-02221-2
doi: 10.1007/s10295-019-02221-2
pubmed: 31375945
Hemati A, Nazari M, Asgari Lajayer B, Smith DL, Astatkie T (2022) Lignocellulosics in plant cell wall and their potential biological degradation. Folia Microbiol (Praha) 67(5):671–681. https://doi.org/10.1007/s12223-022-00974-5
doi: 10.1007/s12223-022-00974-5
pubmed: 35508797
Hu Y, Li M, Liu Z, Song X, Qu Y, Qin Y (2021a) Carbon catabolite repression involves physical interaction of the transcription factor CRE1/CreA and the Tup1-Cyc8 complex in Penicillium oxalicum and Trichoderma reesei. Biotechnol Biofuels 14(1):244. https://doi.org/10.1186/s13068-021-02092-9
doi: 10.1186/s13068-021-02092-9
pubmed: 34952627
pmcid: 8710005
Hu Y, Liu Z, Xu S, Zhao Q, Liu G, Song X, Qu Y, Qin Y (2023) The interaction between the histone acetyltransferase complex Hat1-Hat2 and transcription factor AmyR provides a molecular brake to regulate amylase gene expression. Mol Microbiol 119(4):471–491. https://doi.org/10.1111/mmi.15036
doi: 10.1111/mmi.15036
pubmed: 36760021
Hu Y, Zhao K, Qu Y, Song X, Zhao J, Qin Y (2021b) Penicillium oxalicum S-adenosylmethionine synthetase is essential for the viability of fungal cells and the expression of genes encoding cellulolytic enzymes. Fungal Biol 125(1):1–11. https://doi.org/10.1016/j.funbio.2020.09.004
doi: 10.1016/j.funbio.2020.09.004
pubmed: 33317771
Jing L, Zhao S, Xue JL, Zhang Z, Yang Q, Xian L, Feng JX (2015) Isolation and characterization of a novel Penicillium oxalicum strain Z1-3 with enhanced cellobiohydrolase production using cellulase-hydrolyzed sugarcane bagasse as carbon source. Ind Crop Prod 77:666–675. https://doi.org/10.1016/j.indcrop.2015.09.052
doi: 10.1016/j.indcrop.2015.09.052
Lenz AR, Balbinot E, de Abreu FP, de Oliveira NS, Fontana RC, de Avila E, Silva S, Park MS, Lim YW, Houbraken J, Camassola M, Dillon AJP (2022b) Taxonomy, comparative genomics and evolutionary insights of Penicillium ucsense: a novel species in series Oxalica. Antonie Van Leeuwenhoek 115(8):1009–1029. https://doi.org/10.1007/s10482-022-01746-4
doi: 10.1007/s10482-022-01746-4
pubmed: 35678932
Lenz AR, Balbinot E, Souza de Oliveira N, Abreu FP, Casa PL, Camassola M, Perez-Rueda E, de Avila E, Silva S, Dillon AJP (2022a) Analysis of carbohydrate-active enzymes and sugar transporters in Penicillium echinulatum: a genome-wide comparative study of the fungal lignocellulolytic system. Gene. 822:146345. https://doi.org/10.1016/j.gene.2022.146345
doi: 10.1016/j.gene.2022.146345
pubmed: 35189252
Li CX, Liao LS, Wan XD, Zhang FF, Zhang T, Luo XM, Zhao S, Feng JX (2021) PoxCbh, a novel CENPB-type HTH domain protein, regulates cellulase and xylanase gene expression in Penicillium oxalicum. Mol Microbiol 116(1):140–153. https://doi.org/10.1111/mmi.14696
doi: 10.1111/mmi.14696
pubmed: 33561892
Li CX, Liu L, Zhang T, Luo XM, Feng JX, Zhao S (2022b) Three-dimensional genome map of the filamentous fungus Penicillium oxalicum. Microbiol Spectr 10(3):e0212121. https://doi.org/10.1128/spectrum.02121-21
doi: 10.1128/spectrum.02121-21
pubmed: 35499317
Li Y, Song W, Han X, Wang Y, Rao S, Zhang Q, Zhou J, Li J, Liu S, Du G (2022a) Recent progress in key lignocellulosic enzymes: enzyme discovery, molecular modifications, production, and enzymatic biomass saccharification. Bioresour Technol 363:127986. https://doi.org/10.1016/j.biortech.2022.127986
doi: 10.1016/j.biortech.2022.127986
pubmed: 36126851
Li Z, Liu G, Qu Y (2017) Improvement of cellulolytic enzyme production and performance by rational designing expression regulatory network and enzyme system composition. Bioresour Technol 245(Pt B):1718–1726. https://doi.org/10.1016/j.biortech.2017.06.120
doi: 10.1016/j.biortech.2017.06.120
pubmed: 28684177
Li Z, Yao G, Wu R, Gao L, Kan Q, Liu M, Yang P, Liu G, Qin Y, Song X, Zhong Y, Fang X, Qu Y (2015) Synergistic and dose-controlled regulation of cellulase gene expression in Penicillium oxalicum. PLoS Genet 11(9):e1005509. https://doi.org/10.1371/journal.pgen.1005509
doi: 10.1371/journal.pgen.1005509
pubmed: 26360497
pmcid: 4567317
Liao LS, Li CX, Zhang FF, Yan YS, Luo XM, Zhao S, Feng JX (2019) How an essential Zn2Cys6 transcription factor PoxCxrA regulates cellulase gene expression in ascomycete fungi? Biotechnol Biofuels 12:105. https://doi.org/10.1186/s13068-019-1444-5
doi: 10.1186/s13068-019-1444-5
pubmed: 31073329
pmcid: 6498484
Lin HJ, Xian L, Zhang QJ, Luo XM, Xu QS, Yang Q, Duan CJ, Liu JL, Tang JL, Feng JX (2011) Production of raw cassava starch-degrading enzyme by Penicillium and its use in conversion of raw cassava flour to ethanol. J Ind Microbiol Biotechnol 38(6):733–742. https://doi.org/10.1007/s10295-010-0910-7
doi: 10.1007/s10295-010-0910-7
pubmed: 21120680
Lin YY, Zhao S, Lin X, Zhang T, Li CX, Luo XM, Feng JX (2021) Improvement of cellulase and xylanase production in Penicillium oxalicum under solid-state fermentation by flippase recombination enzyme/ recognition target-mediated genetic engineering of transcription repressors. Bioresour Technol 337:125366. https://doi.org/10.1016/j.biortech.2021.125366
doi: 10.1016/j.biortech.2021.125366
pubmed: 34144430
Liu G, Zhang L, Qin Y, Zou G, Li Z, Yan X, Wei X, Chen M, Chen L, Zheng K, Zhang J, Ma L, Li J, Liu R, Xu H, Bao X, Fang X, Wang L, Zhong Y et al (2013b) Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Rep 3:1569. https://doi.org/10.1038/srep01569
doi: 10.1038/srep01569
pubmed: 23535838
pmcid: 3610096
Liu G, Zhang L, Wei X, Zou G, Qin Y, Ma L, Li J, Zheng H, Wang S, Wang C, Xun L, Zhao GP, Zhou Z, Qu Y (2013a) Genomic and secretomic analyses reveal unique features of the lignocellulolytic enzyme system of Penicillium decumbens. PloS One 8(2):e55185. https://doi.org/10.1371/journal.pone.0055185
doi: 10.1371/journal.pone.0055185
pubmed: 23383313
pmcid: 3562324
Liu HQ, Feng Y, Zhao DQ, Jiang JX (2012) Evaluation of cellulases produced from four fungi cultured on furfural residues and microcrystalline cellulose. Biodegradation. 23(3):465–472. https://doi.org/10.1007/s10532-011-9525-6
doi: 10.1007/s10532-011-9525-6
pubmed: 22116409
Long L, Wang W, Liu Z, Lin Y, Wang J, Lin Q, Ding S (2023) Insights into the capability of the lignocellulolytic enzymes of Penicillium parvum 4-14 to saccharify corn bran after alkaline hydrogen peroxide pretreatment. Biotechnol Biofuels Bioprod 16(1):79. https://doi.org/10.1186/s13068-023-02319-x
doi: 10.1186/s13068-023-02319-x
pubmed: 37170321
pmcid: 10176746
Ma B, Luo XM, Zhao S, Feng JX (2023) Protein kinase PoxMKK1 regulates plant-polysaccharide-degrading enzyme biosynthesis, mycelial growth and conidiation in Penicillium oxalicum. J Fungi 9(4):397. https://doi.org/10.3390/jof9040397
doi: 10.3390/jof9040397
Ma B, Ning YN, Li CX, Tian D, Guo H, Pang XM, Luo XM, Zhao S, Feng JX (2021) A mitogen-activated protein kinase PoxMK1 mediates regulation of the production of plant-biomass-degrading enzymes, vegetative growth, and pigment biosynthesis in Penicillium oxalicum. Appl Microbiol Biotechnol 105(2):661–678. https://doi.org/10.1007/s00253-020-11020-0
doi: 10.1007/s00253-020-11020-0
pubmed: 33409610
Mäkelä MR, Mansouri S, Wiebenga A, Rytioja J, de Vries RP, Hildén KS (2016) Penicillium subrubescens is a promising alternative for Aspergillus niger in enzymatic plant biomass saccharification. N Biotechnol 33(6):834–841. https://doi.org/10.1016/j.nbt.2016.07.014
doi: 10.1016/j.nbt.2016.07.014
pubmed: 27469436
Marjamaa K, Toth K, Bromann PA, Szakacs G, Kruus K (2013) Novel Penicillium cellulases for total hydrolysis of lignocellulosics. Enzyme Microb Technol 52(6-7):358–369. https://doi.org/10.1016/j.enzmictec.2013.03.003
doi: 10.1016/j.enzmictec.2013.03.003
pubmed: 23608505
Mendonça M, Barroca M, Collins T (2023) Endo-1,4-β-xylanase-containing glycoside hydrolase families: characteristics, singularities and similarities. Biotechnol Adv 65:108148. https://doi.org/10.1016/j.biotechadv.2023.108148
doi: 10.1016/j.biotechadv.2023.108148
pubmed: 37030552
Monclaro AV, Gorgulho Silva CO, Gomes HAR, Moreira LRS, Filho EXF (2022) The enzyme interactome concept in filamentous fungi linked to biomass valorization. Bioresour Technol 344(Pt A):126200. https://doi.org/10.1016/j.biortech.2021.126200
doi: 10.1016/j.biortech.2021.126200
pubmed: 34710591
Morgan T, Falkoski DL, Tavares MP, Oliveira MB, Guimarães VM, de Oliveira Mendes TA (2022) Penicillium Ochrochloron RLS11 secretome containing carbohydrate-active enzymes improves commercial enzyme mixtures during sugarcane straw saccharification. Appl Biochem Biotechnol 194(7):2946–2967. https://doi.org/10.1007/s12010-022-03898-5
doi: 10.1007/s12010-022-03898-5
pubmed: 35312974
Ning P, Yang G, Hu L, Sun J, Shi L, Zhou Y, Wang Z, Yang J (2021) Recent advances in the valorization of plant biomass. Biotechnol Biofuels 14(1):102. https://doi.org/10.1186/s13068-021-01949-3
doi: 10.1186/s13068-021-01949-3
pubmed: 33892780
pmcid: 8063360
Ning YN, Tian D, Tan ML, Luo XM, Zhao S, Feng JX (2023) Regulation of fungal raw-starch-degrading enzyme production depends on transcription factor phosphorylation and recruitment of the Mediator complex. Commun Biol 6(1):1032. https://doi.org/10.1038/s42003-023-05404-x
doi: 10.1038/s42003-023-05404-x
pubmed: 37828083
pmcid: 10570388
Pang XM, Tian D, Zhang T, Liao LS, Li CX, Luo XM, Feng JX, Zhao S (2021) G protein γ subunit modulates expression of plant-biomass-degrading enzyme genes and mycelial-development-related genes in Penicillium oxalicum. Appl Microbiol Biotechnol 105(11):4675–4691. https://doi.org/10.1007/s00253-021-11370-3
doi: 10.1007/s00253-021-11370-3
pubmed: 34076714
Passos DDF, Pereira N, Castro AMD (2018) A comparative review of recent advances in cellulases production by Aspergillus, Penicillium and Trichoderma strains and their use for lignocellulose deconstruction. Curr Opin Green Sustain Chem 14:60–66. https://doi.org/10.1016/j.cogsc.2018.06.003
doi: 10.1016/j.cogsc.2018.06.003
Petersen C, Sørensen T, Nielsen MR, Sondergaard TE, Sørensen JL, Fitzpatrick DA, Frisvad JC, Nielsen KL (2023) Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events. IMA Fungus 14(1):3. https://doi.org/10.1186/s43008-023-00108-7
doi: 10.1186/s43008-023-00108-7
pubmed: 36726175
pmcid: 9893605
Peterson R, Nevalainen H (2012) Trichoderma reesei RUT-C30--thirty years of strain improvement. Microbiology (Reading) 158(Pt 1):58–68. https://doi.org/10.1099/mic.0.054031-0
doi: 10.1099/mic.0.054031-0
pubmed: 21998163
Pham HM, Le DT, Le LT, Chu PTM, Tran LH, Pham TT, Nguyen HM, Luu TT, Hoang H, Chu HH (2023) A highly quality genome sequence of Penicillium oxalicum species isolated from the root of Ixora chinensis in Vietnam. G3 (Bethesda) 13(2):jkac300. https://doi.org/10.1093/g3journal/jkac300
doi: 10.1093/g3journal/jkac300
pubmed: 36454044
Randhawa A, Ogunyewo OA, Eqbal D, Gupta M, Yazdani SS (2018) Disruption of zinc finger DNA binding domain in catabolite repressor Mig1 increases growth rate, hyphal branching, and cellulase expression in hypercellulolytic fungus Penicillium funiculosum NCIM1228. Biotechnol Biofuels 11:15. https://doi.org/10.1186/s13068-018-1011-5
doi: 10.1186/s13068-018-1011-5
pubmed: 29416560
pmcid: 5784589
Ribeiro LFC, Chelius C, Boppidi KR, Naik NS, Hossain S, Ramsey JJJ, Kumar J, Ribeiro LF, Ostermeier M, Tran B, Ah Goo Y, de Assis LJ, Ulas M, Bayram O, Goldman GH, Lincoln S, Srivastava R, Harris SD, Marten MR (2019) Comprehensive analysis of Aspergillus nidulans PKA phosphorylome identifies a novel mode of CreA regulation. mBio. 10(2):e02825–e02818. https://doi.org/10.1128/mBio.02825-18
doi: 10.1128/mBio.02825-18
pubmed: 31040248
pmcid: 6495382
Shruthi BR, Achur RNH, Nayaka Boramuthi T (2020) Optimized solid-state fermentation medium enhances the multienzymes production from Penicillium citrinum and Aspergillus clavatus. Curr Microbiol 77(9):2192–2206. https://doi.org/10.1007/s00284-020-02036-w
doi: 10.1007/s00284-020-02036-w
pubmed: 32451686
Shyama PS, Shilpi G (2014) Optimization of xylanase production by Penicillium citrinum xym2 and application in saccharification of agro-residues. Biocatal Biotransformation 3(4):188–196. https://doi.org/10.1016/j.bcab.2014.03.003
doi: 10.1016/j.bcab.2014.03.003
Sreeja-Raju A, Christopher M, Kooloth-Valappil P, Kuni-Parambil R, Gokhale DV, Sankar M, Abraham A, Pandey A, Sukumaran RK (2020) Penicillium janthinellum NCIM1366 shows improved biomass hydrolysis and a larger number of CAZymes with higher induction levels over Trichoderma reesei RUT-C30. Biotechnol Biofuels 13(1):196. https://doi.org/10.1186/s13068-020-01830-9
doi: 10.1186/s13068-020-01830-9
pubmed: 33292411
pmcid: 7706291
Sukumaran RK, Christopher M, Kooloth-Valappil P, Sreeja-Raju A, Mathew RM, Sankar M, Puthiyamadam A, Adarsh VP, Aswathi A, Rebinro V, Abraham A, Pandey A (2021) Addressing challenges in production of cellulases for biomass hydrolysis: Targeted interventions into the genetics of cellulase producing fungi. Bioresour Technol 329:124746. https://doi.org/10.1016/j.biortech.2021.124746
doi: 10.1016/j.biortech.2021.124746
pubmed: 33610429
Sun H, Zhao P, Ge X, Xia Y, Hao Z, Liu J, Peng M (2010) Recent advances in microbial raw starch degrading enzymes. Appl Biochem Biotechnol 160(4):988–1003. https://doi.org/10.1007/s12010-009-8579-y
doi: 10.1007/s12010-009-8579-y
pubmed: 19277485
Sun HY, Zhao PJ, Peng M (2008) Application of maltitol to improve production of raw starch digesting glucoamylase by Aspergillus niger F-08. World J Microbiol Biotechnol 24(11):2613–2618. https://doi.org/10.1007/s11274-008-9785-4
doi: 10.1007/s11274-008-9785-4
Ullah SF, Souza AA, Hamann PRV, Ticona ARP, Oliveira GM, Barbosa JARG, Freitas SM, Noronha EF (2019) Structural and functional characterization of xylanase purified from Penicillium chrysogenum produced in response to raw agricultural waste. Int J Biol Macromol 127:385–395. https://doi.org/10.1016/j.ijbiomac.2019.01.057
doi: 10.1016/j.ijbiomac.2019.01.057
pubmed: 30654038
Vaishnav N, Singh A, Adsul M, Dixit P, Sandhu SK, Mathur A, Puri SK, Singhania RR (2018) Penicillium: the next emerging champion for cellulase production. Bioresource Technol Rep 2018(2):131–140. https://doi.org/10.1016/j.biteb.2018.04.003
doi: 10.1016/j.biteb.2018.04.003
Wang BT, Hu S, Yu XY, Jin L, Zhu YJ, Jin FJ (2020a) Studies of cellulose and starch utilization and the regulatory mechanisms of related enzymes in fungi. Polymers (Basel) 12(3):530. https://doi.org/10.3390/polym12030530
doi: 10.3390/polym12030530
pubmed: 32121667
Wang K, Zhang N, Pearce R, Yi S, Zhao X (2021) Comparative secretomics analysis reveals the major components of Penicillium oxalicum 16 and Trichoderma reesei RUT-C30. Microorganisms. 9(10):2042. https://doi.org/10.3390/microorganisms9102042
doi: 10.3390/microorganisms9102042
pubmed: 34683363
pmcid: 8538001
Wang L, Zhao S, Chen XX, Deng QP, Li CX, Feng JX (2018) Secretory overproduction of a raw starch-degrading glucoamylase in Penicillium oxalicum using strong promoter and signal peptide. Appl Microbiol Biotechnol 102(21):9291–9301. https://doi.org/10.1007/s00253-018-9307-8
doi: 10.1007/s00253-018-9307-8
pubmed: 30155751
Wang Q, Zhong C, Xiao H (2020b) Genetic engineering of filamentous fungi for efficient protein expression and secretion. Front Bioeng Biotechnol 8:293. https://doi.org/10.3389/fbioe.2020.00293
doi: 10.3389/fbioe.2020.00293
pubmed: 32322579
pmcid: 7156587
Wu G, Jurick Ii WM, Lichtner FJ, Peng H, Yin G, Gaskins VL, Yin Y, Hua SS, Peter KA, Bennett JW (2019) Whole-genome comparisons of Penicillium spp. reveals secondary metabolic gene clusters and candidate genes associated with fungal aggressiveness during apple fruit decay. PeerJ. 7:e6170. https://doi.org/10.7717/peerj.6170
doi: 10.7717/peerj.6170
pubmed: 30643697
pmcid: 6330040
Xia C, Gao L, Li Z, Liu G, Song X (2022) Functional analysis of the transcriptional activator XlnR of Penicillium oxalicum. J Appl Microbiol 132(2):1112–1120. https://doi.org/10.1111/jam.15276
doi: 10.1111/jam.15276
pubmed: 34467597
Xiong YR, Zhao S, Fu LH, Liao XZ, Li CX, Yan YS, Liao LS, Feng JX (2018) Characterization of novel roles of a HMG-box protein PoxHmbB in biomass-degrading enzyme production by Penicillium oxalicum. Appl Microbiol Biotechnol 102(8):3739–3753. https://doi.org/10.1007/s00253-018-8867-y
doi: 10.1007/s00253-018-8867-y
pubmed: 29511847
Xu QS, Yan YS, Feng JX (2016) Efficient hydrolysis of raw starch and ethanol fermentation: a novel raw starch-digesting glucoamylase from Penicillium oxalicum. Biotechnol Biofuels 9:216. https://doi.org/10.1186/s13068-016-0636-5
doi: 10.1186/s13068-016-0636-5
pubmed: 27777618
pmcid: 5069817
Xu S, Gao S, An Y (2023) Research progress of engineering microbial cell factories for pigment production. Biotechnol Adv 65:108150. https://doi.org/10.1016/j.biotechadv.2023.108150
doi: 10.1016/j.biotechadv.2023.108150
pubmed: 37044266
Yan YS, Zhao S, Liao LS, He QP, Xiong YR, Wang L, Li CX, Feng JX (2017) Transcriptomic profiling and genetic analyses reveal novel key regulators of cellulase and xylanase gene expression in Penicillium oxalicum. Biotechnol Biofuels 10:279. https://doi.org/10.1186/s13068-017-0966-y
doi: 10.1186/s13068-017-0966-y
pubmed: 29201143
pmcid: 5700522
Yang YJ, Liu Y, Liu DD, Guo WZ, Wang LX, Wang XJ, Lv HX, Yang Y, Liu Q, Tian CG (2022) Development of a flow cytometry-based plating-free system for strain engineering in industrial fungi. Appl Microbiol Biotechnol 106(2):713–727. https://doi.org/10.1007/s00253-021-11733-w
doi: 10.1007/s00253-021-11733-w
pubmed: 34921331
Zhang MY, Zhao S, Ning YN, Fu LH, Li CX, Wang Q, You R, Wang CY, Xu HN, Luo XM, Feng JX (2019) Identification of an essential regulator controlling the production of raw-starch-digesting glucoamylase in Penicillium oxalicum. Biotechnol Biofuels 12:7. https://doi.org/10.1186/s13068-018-1345-z
doi: 10.1186/s13068-018-1345-z
pubmed: 30622649
pmcid: 6318894
Zhang T, Li HZ, Li WT, Tian D, Ning YN, Liang X, Tan J, Zhao YH, Luo XM, Feng JX, Zhao S (2023) Kinase POGSK-3β modulates fungal plant polysaccharide-degrading enzyme production and development. Appl Microbiol Biotechnol 107(11):3605–3620. https://doi.org/10.1007/s00253-023-12548-7
doi: 10.1007/s00253-023-12548-7
pubmed: 37119203
Zhang T, Mai RM, Fang QQ, Ou JF, Mo LX, Tian D, Li CX, Gu LS, Luo XM, Feng JX (2021) Zhao S. Regulatory function of the novel transcription factor CxrC in Penicillium oxalicum. Mol Microbiol 116(6):1512–1532. https://doi.org/10.1111/mmi.14843
doi: 10.1111/mmi.14843
pubmed: 34797006
Zhang X, Hu Y, Liu G, Liu M, Li Z, Zhao J, Song X, Zhong Y, Qu Y, Wang L, Qin Y (2022) The complex Tup1-Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes. Mol Microbiol 117(5):1002–1022. https://doi.org/10.1111/mmi.14885
doi: 10.1111/mmi.14885
pubmed: 35072962
Zhang X, Li M, Zhu Y, Yang L, Li Y, Qu J, Wang L, Zhao J, Qu Y, Qin Y (2020) Penicillium oxalicum putative methyltransferase Mtr23B has similarities and differences with LaeA in regulating conidium development and glycoside hydrolase gene expression. Fungal Genet Biol 143:103445. https://doi.org/10.1016/j.fgb.2020.103445
doi: 10.1016/j.fgb.2020.103445
pubmed: 32822857
Zhang Z, Liu JL, Lan JY, Duan CJ, Ma QS, Feng JX (2014) Predominance of Trichoderma and Penicillium in cellulolytic aerobic filamentous fungi from subtropical and tropical forests in China, and their use in finding highly efficient β-glucosidase. Biotechnol Biofuels 7:107. https://doi.org/10.1186/1754-6834-7-107
doi: 10.1186/1754-6834-7-107
Zhao S, Liao XZ, Wang JX, Ning YN, Li CX, Liao LS, Liu Q, Jiang Q, Gu LS, Fu LH, Yan YS, Xiong YR, He QP, Su LH, Duan CJ, Luo XM, Feng JX (2019) Transcription factor Atf1 regulates expression of cellulase and xylanase genes during solid-state fermentation of Ascomycetes. Appl Environ Microbiol 85(24):e01226–e01219. https://doi.org/10.1128/AEM.01226-19
doi: 10.1128/AEM.01226-19
pubmed: 31604764
pmcid: 6881793
Zhao S, Mai RM, Zhang T, Feng XZ, Li WT, Wang WX, Luo XM, Feng JX (2022c) Simultaneous manipulation of transcriptional regulator CxrC and translational elongation factor eEF1A enhances the production of plant-biomass-degrading enzymes of Penicillium oxalicum. Bioresour Technol 351:127058. https://doi.org/10.1016/j.biortech.2022.127058
doi: 10.1016/j.biortech.2022.127058
pubmed: 35339654
Zhao S, Mo LX, Li WT, Jiang LL, Meng YY, Ou JF, Liao LS, Yan YS, Luo XM, Feng JX (2023c) Arginine methyltransferases PRMT2 and PRMT3 are essential for biosynthesis of plant-polysaccharide-degrading enzymes in Penicillium oxalicum. PLoS Genet 19(7):e1010867. https://doi.org/10.1371/journal.pgen.1010867
doi: 10.1371/journal.pgen.1010867
pubmed: 37523410
pmcid: 10414604
Zhao S, Tan MZ, Wang RX, Ye FT, Chen YP, Luo XM, Feng JX (2022a) Combination of genetic engineering and random mutagenesis for improving production of raw-starch-degrading enzymes in Penicillium oxalicum. Microb Cell Fact 21(1):272. https://doi.org/10.1186/s12934-022-01997-w
doi: 10.1186/s12934-022-01997-w
pubmed: 36566178
pmcid: 9790131
Zhao S, Wang JX, Hou R, Ning YN, Chen ZX, Liu Q, Luo XM, Feng JX (2023b) Novel transcription factor CXRD regulates cellulase and xylanase biosynthesis in Penicillium oxalicum under solid-state fermentation. Appl Environ Microbiol:e0036023. Advance online publication. https://doi.org/10.1128/aem.00360-23
Zhao S, Wang ZB, Wang YZ, Yang PY, Luo XM, Wu AM, Feng JX (2023a) Sustainable coproduction of xylooligosaccharide, single-cell protein and lignin-adsorbent through whole components’ utilization of sugarcane bagasse with high solid loading. Sep Purif Technol 308:122916. https://doi.org/10.1016/j.seppur.2022.122916
doi: 10.1016/j.seppur.2022.122916
Zhao S, Xiang B, Yang L, Chen J, Zhu C, Chen Y, Cui J, Hu S, Hu Y (2022b) Genetic modifications of critical regulators provide new insights into regulation modes of raw-starch-digesting enzyme expression in Penicillium. Biotechnol Biofuels Bioprod 15(1):62. https://doi.org/10.1186/s13068-022-02162-6
doi: 10.1186/s13068-022-02162-6
pubmed: 35641999
pmcid: 9158223
Zhao S, Yan YS, He QP, Yang L, Yin X, Li CX, Mao LC, Liao LS, Huang JQ, Xie SB, Nong QD, Zhang Z, Jing L, Xiong YR, Duan CJ, Liu JL, Feng JX (2016) Comparative genomic, transcriptomic and secretomic profiling of Penicillium oxalicum HP7-1 and its cellulase and xylanase hyper-producing mutant EU2106, and identification of two novel regulatory genes of cellulase and xylanase gene expression. Biotechnol Biofuels 9:203. https://doi.org/10.1186/s13068-016-0616-9
doi: 10.1186/s13068-016-0616-9
pubmed: 27688806
pmcid: 5035457
Zhao S, Zhang GL, Chen C, Yang Q, Luo XM, Wang ZB, Wu AM, Feng JX (2021) A combination of mild chemical pre-treatment and enzymatic hydrolysis efficiently produces xylooligosaccharides from sugarcane bagasse. J Clean Prod 291:125972. https://doi.org/10.1016/j.jclepro.2021.125972
doi: 10.1016/j.jclepro.2021.125972
Zimmermann A, Prieto-Vivas JE, Cautereels C, Gorkovskiy A, Steensels J, Van de Peer Y, Verstrepen KJ (2023) A Cas3-base editing tool for targetable in vivo mutagenesis. Nat Commun 14(1):3389. https://doi.org/10.1038/s41467-023-39087-z
doi: 10.1038/s41467-023-39087-z
pubmed: 37296137
pmcid: 10256805