Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 Jan 2024
03 Jan 2024
Historique:
received:
27
10
2023
accepted:
25
12
2023
medline:
4
1
2024
pubmed:
4
1
2024
entrez:
3
1
2024
Statut:
epublish
Résumé
While microplastics have been recently detected in human blood and the placenta, their impact on human health is not well understood. Using a mouse model of environmental exposure during pregnancy, our group has previously reported that exposure to polystyrene micro- and nanoplastics throughout gestation results in fetal growth restriction. While polystyrene is environmentally relevant, polyethylene is the most widely produced plastic and amongst the most commonly detected microplastic in drinking water and human blood. In this study, we investigated the effect of maternal exposure to polyethylene micro- and nanoplastics on fetal growth and placental function. Healthy, pregnant CD-1 dams were divided into three groups: 10
Identifiants
pubmed: 38172192
doi: 10.1038/s41598-023-50781-2
pii: 10.1038/s41598-023-50781-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
399Informations de copyright
© 2024. The Author(s).
Références
Arthur, C., Baker, J. & Bamford, H. (Eds.). Proceedings of the International Research Workshop on the Occurrence, Effects and Fate of Microplastics Marine Debris. NOAA Technical Memorandum NOS-OR&R-30 (2009).
Pinto da Costa, J., Santos, P. S. M., Duarte, A. C. & Rocha-Santos, T. Nano (plastics) in the environment—sources, fates and effects. Sci. Total Environ. 566–567, 15–26 (2016).
Hartmann, N. B. et al. Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris. Environ. Sci. Technol. 53, 1039–1047 (2019).
doi: 10.1021/acs.est.8b05297
pubmed: 30608663
Enyoh, C. E. et al. Microplastics exposure routes and toxicity studies to ecosystems: An overview. Environ. Anal. Health Toxicol. 35, e2020004 (2020).
doi: 10.5620/eaht.e2020004
pubmed: 32570999
pmcid: 7308665
Koelmans, A. A. et al. Microplastics in freshwaters and drinking water: Critical review and assessment of data quality. Water Res. 155, 410–422 (2019).
doi: 10.1016/j.watres.2019.02.054
pubmed: 30861380
pmcid: 6449537
Geyer, R., Jambeck, J. R. & Law, K. L. Production, use, and fate of all plastics ever made. Sci. Adv. 3, e1700782 (2017).
doi: 10.1126/sciadv.1700782
pubmed: 28776036
pmcid: 5517107
Leslie, H. A. et al. Discovery and quantification of plastic particle pollution in human blood. Environ. Int. 163, 107199 (2022).
doi: 10.1016/j.envint.2022.107199
pubmed: 35367073
Ragusa, A. et al. Plasticenta: first evidence of microplastics in human placenta. Environ. Int. 146, 106274 (2021).
doi: 10.1016/j.envint.2020.106274
pubmed: 33395930
Amereh, F. et al. Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies. Environ. Pollut. 314, 120174 (2022).
doi: 10.1016/j.envpol.2022.120174
pubmed: 36113646
Zhu, L. et al. Identification of microplastics in human placenta using laser direct infrared spectroscopy. Sci. Total Environ. 856, 159060 (2023).
doi: 10.1016/j.scitotenv.2022.159060
pubmed: 36174702
Braun, T. et al. Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics. 13, 921 (2021).
doi: 10.3390/pharmaceutics13070921
pubmed: 34206212
pmcid: 8308544
Zhang, J., Wang, L., Trasande, L. & Kannan, K. Occurrence of polyethylene terephthalate and polycarbonate microplastics in infant and adult feces. Environ. Sci. Technol. Lett. 8, 989–994 (2021).
doi: 10.1021/acs.estlett.1c00559
Georgiades, P., Ferguson-Smith, A. C. & Burton, G. J. Comparative developmental anatomy of the murine and human definitive placentae. Placenta. 23, 3–19 (2002).
doi: 10.1053/plac.2001.0738
pubmed: 11869088
Aghaei, Z. et al. Maternal exposure to polystyrene micro- and nanoplastics causes fetal growth restriction in mice. Environ. Sci. Technol. Lett. 9, 426–430 (2022).
doi: 10.1021/acs.estlett.2c00186
Chen, G. et al. Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice. Sci. Total Environ. 854, 158666 (2023).
doi: 10.1016/j.scitotenv.2022.158666
pubmed: 36108837
Aghaei, Z. et al. Maternal exposure to polystyrene microplastics alters placental metabolism in mice. Metabolomics. 19, 1 (2022).
doi: 10.1007/s11306-022-01967-8
pubmed: 36538272
Luo, T. et al. Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring. Environ. Pollut. 255, 113122 (2019).
doi: 10.1016/j.envpol.2019.113122
pubmed: 31520900
Luo, T. et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring. Environ. Sci. Technol. 53, 10978–10992 (2019).
doi: 10.1021/acs.est.9b03191
pubmed: 31448906
Hu, J. et al. Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice. Reprod. Toxicol. 106, 42–50 (2021).
doi: 10.1016/j.reprotox.2021.10.002
pubmed: 34626775
Harvey, N. E. et al. Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring. Environ. Sci. Adv. 2, 622–628 (2023).
Dibbon, K. C. et al. Polystyrene micro- and nanoplastics cause placental dysfunction in mice. Biol. Reprod. ioad126 (2023).
Zaheer, J. et al. Pre/post-natal exposure to microplastic as a potential risk factor for autism spectrum disorder. Environ. Int. 161, 107121 (2022).
doi: 10.1016/j.envint.2022.107121
pubmed: 35134716
Rennie, M. Y. et al. Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice. Am. J. Physiol. Heart Circ. Physiol. 302, H1261–H1273 (2012).
doi: 10.1152/ajpheart.00776.2011
pubmed: 22268107
pmcid: 3311476
Arbeille, P. et al. Assessment of the fetal PO2 changes by cerebral and umbilical Doppler on lamb fetuses during acute hypoxia. Ultrasound Med. Biol. 21, 861–870 (1995).
doi: 10.1016/0301-5629(95)00025-M
pubmed: 7491742
Cahill, L. S., Zhou, Y.-Q., Seed, M., Macgowan, C. K. & Sled, J. G. Brain sparing in fetal mice: BOLD MRI and Doppler ultrasound show blood redistribution during hypoxia. J. Cere. Blood Flow. Metab. 34, 1082–1088 (2014).
doi: 10.1038/jcbfm.2014.62
Adamson, S. L. Arterial pressure, vascular input impedance, and resistance as determinants of pulsatile blood flow in the umbilical artery. Eur. J. Obstetrics Gynecol. Reprod. Biol. 84, 119–125 (1999).
doi: 10.1016/S0301-2115(98)00320-0
Han, Y. et al. No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestation and neonatal period. Toxicol. Res. 37, 443–450 (2021).
doi: 10.1007/s43188-020-00086-7
pubmed: 34631501
pmcid: 8476695
Lithner, D., Larsson, A. & Dave, G. Environmental and health hazard ranking and assessment of plastic polymers based on chemical composition. Sci. Total Environ. 409, 3309–3324 (2011).
doi: 10.1016/j.scitotenv.2011.04.038
pubmed: 21663944
Gumus, H. G. et al. Ultrasound-guided intrauterine labeling of rat fetuses. Gynecol. Obstet. Invest. 83, 116–123 (2018).
doi: 10.1159/000454766
pubmed: 28719908
Eerkes-Medrano, D., Thompson, R. C. & Aldridge, D. C. Microplastics in freshwater systems: A review of the emerging threats, identification of knowledge gaps and prioritisation of research needs. Water Res. 75, 63–82 (2015).
doi: 10.1016/j.watres.2015.02.012
pubmed: 25746963
Materić, D. et al. Presence of nanoplastics in rural and remote surface waters. Environ. Res. Lett. 17, 054036 (2022).
doi: 10.1088/1748-9326/ac68f7
Zhou, Y.-Q. et al. Assessment of flow distribution in the mouse fetal circulation at late gestation by high-frequency Doppler ultrasound. Physiol. Genomics. 46, 602–614 (2014).
doi: 10.1152/physiolgenomics.00049.2014
pubmed: 24963005
Lindsey, M. L., Kassiri, Z., Virag, J. A. I., de Castro Brás, L. E. & Scherrer-Crosbie, M. Guidelines for measuring cardiac physiology in mice. Am. J. Physiol. Heart Circ. Physiol. 314, H733–H752 (2018).
doi: 10.1152/ajpheart.00339.2017
pubmed: 29351456
pmcid: 5966769
Golub, M. S. & Sobin, C. A. Statistical modeling with litter as a random effect in mixed models to manage “interlitter likeness”. Neurotoxicol. Teratol. 77, 106841 (2020).
doi: 10.1016/j.ntt.2019.106841
pubmed: 31863841