Adipocyte size, adipose tissue calories, and circulating adipokines, before and after diet-induced weight loss in humans.
Adipocytes
Bomb calorimetry
Caloric restriction
Energy density
FGF21
Leptin
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
04 Jan 2024
04 Jan 2024
Historique:
received:
29
09
2023
accepted:
15
12
2023
medline:
4
1
2024
pubmed:
4
1
2024
entrez:
3
1
2024
Statut:
aheadofprint
Résumé
Adipose tissue (AT) contains a bimodal population of large and small adipocytes. Changes in fat cell size (FCS) distribution and AT caloric density (kcal/g) with weight loss are unclear. We aimed to evaluate changes in FCS and AT calories in weight loss and determine associations with anthropometrics. Healthy adults (6 men/4 women; age 33 ± 11 years; BMI 35 ± 6 kg/m Abdominal large cell diameter (LCD; Δ = -13.2 μm, p = 0.01) and nadir (Δ = -7.3 μm, p = 0.03) decreased. In repeated measures correlations (r Caloric restriction reduces adipocyte LCD and nadir. These changes are associated with FM loss. Larger fat cells should be considered as phenotypic targets for weight loss. clinicaltrials.gov identifier: NCT00687115, May 29, 2008.
Identifiants
pubmed: 38172345
doi: 10.1007/s12020-023-03666-3
pii: 10.1007/s12020-023-03666-3
doi:
Banques de données
ClinicalTrials.gov
['NCT00687115']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
H. Bays, C.A. Dujovne, Adiposopathy is a more rational treatment target for metabolic disease than obesity alone. Curr. Atheroscler. Rep. 8, 144–156 (2006)
doi: 10.1007/s11883-006-0052-6
pubmed: 16510049
T. McLaughlin, A. Sherman, P. Tsao, O. Gonzalez, G. Yee, C. Lamendola, G.M. Reaven, S.W. Cushman, Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 50, 1707–1715 (2007)
doi: 10.1007/s00125-007-0708-y
pubmed: 17549449
J. Murphy, G. Moullec, S. Santosa, Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression. Metabolism 67, 31–40 (2017)
doi: 10.1016/j.metabol.2016.09.009
pubmed: 28081776
M. Kunesova, P. Hlavaty, E. Tvrzicka, B. Stankova, P. Kalouskova, N. Viguerie, T.M. Larsen, M.A. van Baak, S.A. Jebb, J.A. Martinez et al. Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study. Physiol. Res. 61, 597–607 (2012)
doi: 10.33549/physiolres.932414
pubmed: 23098653
J.P. Flatt, Use and storage of carbohydrate and fat. Am. J. Clin. Nutr. 61, 952S–959S (1995)
doi: 10.1093/ajcn/61.4.952S
pubmed: 7900694
A.D. Association, Diagnosis and classification of diabetes mellitus. Diabetes Care 30, S42–S47 (2007)
doi: 10.2337/dc07-S042
R. Ferraro, V.L. Boyce, B. Swinburn, M. De Gregorio, E. Ravussin, Energy cost of physical activity on a metabolic ward in relationship to obesity. Am. J. Clin. Nutr. 53, 1368–1371 (1991)
doi: 10.1093/ajcn/53.6.1368
pubmed: 2035463
A. Basolo, M.H. Shah, V. Parthasarathy, S. Parrington, M. Walter, S.B. Votruba, J. Krakoff, P. Piaggi, D.C. Chang, Thigh adipocyte size is inversely related to energy intake and respiratory quotient in healthy women. Obesity 28, 1129–1140 (2020)
doi: 10.1002/oby.22804
pubmed: 32352645
J. Hirsch, J.L. Knittle, Cellularity of obese and nonobese human adipose tissue. Federation Proc. 29, 1516–1521 (1970)
Baty F., Ritz C., Charles S., Brutsche M., Flandrois J-P, Delignette-Muller M-L: A. Toolbox for nonlinear regression in R: the package nlstools. J. Stat. Software. 66, 1–21 (2015).
T. McLaughlin, C. Lamendola, N. Coghlan, T.C. Liu, K. Lerner, A. Sherman, S.W. Cushman, Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat. Obesity 22, 673–680 (2014)
doi: 10.1002/oby.20209
pubmed: 23666871
J.Z. Bakdash, L.R. Marusich, Repeated measures correlation. Front. Psychol. 8, 456 (2017)
doi: 10.3389/fpsyg.2017.00456
pubmed: 28439244
pmcid: 5383908
J. Frankl, P. Piaggi, J.E. Foley, J. Krakoff, S.B. Votruba, In vitro lipolysis is associated with whole-body lipid oxidation and weight gain in humans. Obesity 25, 207–214 (2017)
doi: 10.1002/oby.21670
pubmed: 27868388
D.L. Johannsen, Y. Tchoukalova, C.S. Tam, J.D. Covington, W. Xie, J.M. Schwarz, S. Bajpeyi, E. Ravussin, Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the “adipose tissue expandability” hypothesis. Diabetes Care 37, 2789–2797 (2014)
doi: 10.2337/dc14-0761
pubmed: 25011943
pmcid: 4170127
A. Hammarstedt, S. Gogg, S. Hedjazifar, A. Nerstedt, U. Smith, Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity. Physiol. Rev. 98, 1911–1941 (2018)
doi: 10.1152/physrev.00034.2017
pubmed: 30067159
M. Laville, J.A. Nazare, Diabetes, insulin resistance and sugars. Obes. Rev. 10, 24–33 (2009)
doi: 10.1111/j.1467-789X.2008.00562.x
pubmed: 19207533
M. Pasarica, H. Xie, D. Hymel, G. Bray, F. Greenway, E. Ravussin, S.R. Smith, Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care 32, 900–902 (2009)
doi: 10.2337/dc08-2240
pubmed: 19228873
pmcid: 2671122
U. White, R.A. Beyl, E. Ravussin, A higher proportion of small adipocytes is associated with increased visceral and ectopic lipid accumulation during weight gain in response to overfeeding in men. Int. J. Obes. 46, 1560–1563 (2022)
doi: 10.1038/s41366-022-01150-y
P.S. MacLean, J.A. Higgins, E.D. Giles, V.D. Sherk, M.R. Jackman, The role for adipose tissue in weight regain after weight loss. Obes. Rev. 16, 45–54 (2015)
doi: 10.1111/obr.12255
pubmed: 25614203
pmcid: 4371661
F.S. Thong, R. Hudson, R. Ross, I. Janssen, T.E. Graham, Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 279, E307–E313 (2000)
doi: 10.1152/ajpendo.2000.279.2.E307
pubmed: 10913030
T. Skurk, C. Alberti-Huber, C. Herder, H. Hauner, Relationship between adipocyte size and adipokine expression and secretion. J. Clin. Endocrinol. Metab. 92, 1023–1033 (2007)
doi: 10.1210/jc.2006-1055
pubmed: 17164304
M.A. Lips, G.H. de Groot, F.J. Berends, R. Wiezer, B.A. van Wagensveld, D.J. Swank, A. Luijten, K.W. van Dijk, H. Pijl, P.L.M. Jansen et al. Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects. Clin. Endocrinol. 81, 862–870 (2014)
doi: 10.1111/cen.12496
K. Mai, F. Schwarz, T. Bobbert, J. Andres, A. Assmann, A.F.H. Pfeiffer, J. Spranger, Relation between fibroblast growth factor–21, adiposity, metabolism, and weight reduction. Metabolism 60, 306–311 (2011)
doi: 10.1016/j.metabol.2010.02.016
pubmed: 20362303
M.L. Headland, P.M. Clifton, J.B. Keogh, Effects of weight Loss on FGF-21 in human subjects: an exploratory study. Int. J. Environ. Res. Public Health 16, 4877 (2019)
doi: 10.3390/ijerph16234877
pubmed: 31817052
pmcid: 6926763
W. Ma, T. Huang, Y. Zheng, M. Wang, G.A. Bray, F.M. Sacks, L. Qi, Weight-Loss Diets, Adiponectin, and Changes in Cardiometabolic Risk in the 2-Year POUNDS Lost Trial. J. Clin. Endocrinol. Metab. 101, 2415–2422 (2016)
doi: 10.1210/jc.2016-1207
pubmed: 27055193
pmcid: 4891796
M. Lafontan, D. Langin, Lipolysis and lipid mobilization in human adipose tissue. Prog. Lipid Res. 48, 275–297 (2009)
doi: 10.1016/j.plipres.2009.05.001
pubmed: 19464318