The logic of recurrent circuits in the primary visual cortex.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
03 Jan 2024
03 Jan 2024
Historique:
received:
20
09
2022
accepted:
27
10
2023
medline:
4
1
2024
pubmed:
4
1
2024
entrez:
3
1
2024
Statut:
aheadofprint
Résumé
Recurrent cortical activity sculpts visual perception by refining, amplifying or suppressing visual input. However, the rules that govern the influence of recurrent activity remain enigmatic. We used ensemble-specific two-photon optogenetics in the mouse visual cortex to isolate the impact of recurrent activity from external visual input. We found that the spatial arrangement and the visual feature preference of the stimulated ensemble and the neighboring neurons jointly determine the net effect of recurrent activity. Photoactivation of these ensembles drives suppression in all cells beyond 30 µm but uniformly drives activation in closer similarly tuned cells. In nonsimilarly tuned cells, compact, cotuned ensembles drive net suppression, while diffuse, cotuned ensembles drive activation. Computational modeling suggests that highly local recurrent excitatory connectivity and selective convergence onto inhibitory neurons explain these effects. Our findings reveal a straightforward logic in which space and feature preference of cortical ensembles determine their impact on local recurrent activity.
Identifiants
pubmed: 38172437
doi: 10.1038/s41593-023-01510-5
pii: 10.1038/s41593-023-01510-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : U19NS107613
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : UF1NS107574
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : U19NS107613
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : R01EY023756
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : K99EY029758
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : F31EY031977
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : RF1MH120680
Organisme : Simons Foundation
ID : SCGB 415569
Organisme : Whitehall Foundation (Whitehall Foundation, Inc.)
ID : Award No: 2023-05-40
Organisme : National Science Foundation (NSF)
ID : DGE 1752814
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : R01EB026953
Informations de copyright
© 2024. The Author(s).
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