Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
04 Jan 2024
04 Jan 2024
Historique:
received:
20
04
2023
accepted:
07
11
2023
medline:
5
1
2024
pubmed:
5
1
2024
entrez:
4
1
2024
Statut:
aheadofprint
Résumé
Predatory bacteria, like the model endoperiplasmic bacterium Bdellovibrio bacteriovorus, show several adaptations relevant to their requirements for locating, entering and killing other bacteria. The mechanisms underlying prey recognition and handling remain obscure. Here we use complementary genetic, microscopic and structural methods to address this deficit. During invasion, the B. bacteriovorus protein CpoB concentrates into a vesicular compartment that is deposited into the prey periplasm. Proteomic and structural analyses of vesicle contents reveal several fibre-like proteins, which we name the mosaic adhesive trimer (MAT) superfamily, and show localization on the predator surface before prey encounter. These dynamic proteins indicate a variety of binding capabilities, and we confirm that one MAT member shows specificity for surface glycans from a particular prey. Our study shows that the B. bacteriovorus MAT protein repertoire enables a broad means for the recognition and handling of diverse prey epitopes encountered during bacterial predation and invasion.
Identifiants
pubmed: 38177296
doi: 10.1038/s41564-023-01552-2
pii: 10.1038/s41564-023-01552-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Organisme : Wellcome Trust (Wellcome)
ID : 220105/Z/20/Z
Organisme : Wellcome Trust (Wellcome)
ID : 215025/Z/18/Z
Organisme : Wellcome Trust (Wellcome)
ID : 209437/Z/17/Z
Informations de copyright
© 2024. The Author(s).
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