Antimalarial artesunate-mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial.


Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
04 Jan 2024
Historique:
received: 11 04 2023
accepted: 14 11 2023
medline: 5 1 2024
pubmed: 5 1 2024
entrez: 4 1 2024
Statut: aheadofprint

Résumé

Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial combination artesunate-mefloquine for the treatment of schistosomiasis in a proof-of-concept, pragmatic, open-label, randomized controlled trial in primary schools of six villages endemic for schistosomiasis in northern Senegal. Children (6-14 years) were eligible if Schistosoma eggs were detected by microscopy in urine and/or stool. In total, 726 children were randomized 1:1 to praziquantel (standard care: 40 mg kg

Identifiants

pubmed: 38177851
doi: 10.1038/s41591-023-02719-4
pii: 10.1038/s41591-023-02719-4
doi:

Banques de données

ClinicalTrials.gov
['NCT03893097']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Emmanuel Bottieau (E)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. ebottieau@itg.be.

Moustapha Mbow (M)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.
Department of Immunology, Cheikh Anta Diop University, Dakar, Senegal.

Isabel Brosius (I)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Clémentine Roucher (C)

Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Cheikh Tidiane Gueye (CT)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.

Ousmane Thiam Mbodj (OT)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.

Babacar Thiendella Faye (BT)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.

Annelies De Hondt (A)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Bart Smekens (B)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Diana Arango (D)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Christophe Burm (C)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Achilleas Tsoumanis (A)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Linda Paredis (L)

Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Yven Van Herrewege (Y)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Idzi Potters (I)

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Joachim Richter (J)

Institute of Tropical Medicine and International Health, Charité Universitätsmedizin, Berlin, Germany.

Anna Rosanas-Urgell (A)

Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Badara Cissé (B)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.

Souleymane Mboup (S)

Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal.

Katja Polman (K)

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Department of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Classifications MeSH