Dynamics of receptor activation by agonists.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
04 Jan 2024
04 Jan 2024
Historique:
received:
01
09
2023
revised:
18
11
2023
accepted:
02
01
2024
medline:
5
1
2024
pubmed:
5
1
2024
entrez:
5
1
2024
Statut:
aheadofprint
Résumé
How do agonists turn on receptors? The model system we have used to address this question is the adult-type skeletal muscle nicotinic acetylcholine receptor (AChR). This ligand-gated ion channel has 2 orthosteric sites (for neurotransmitters) in the extracellular domain linked to an allosteric site (a gate) in the transmembrane domain. The goal of this Perspective is to summarize how measurements of agonist binding energy reveal the dynamics of the neurotransmitter sites and the fundamental link between binding and gating.
Identifiants
pubmed: 38178577
pii: S0006-3495(24)00003-1
doi: 10.1016/j.bpj.2024.01.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Biophysical Society. Published by Elsevier Inc. All rights reserved.