Gilbert's syndrome leads to elevated bilirubin after initiation of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis.

CFTR modulator cystic fibrosis elevated direct bilirubin elexacaftor/tezacaftor/ivacaftor gilbert's syndrome

Journal

Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590

Informations de publication

Date de publication:
05 Jan 2024
Historique:
revised: 15 11 2023
received: 26 06 2023
accepted: 12 12 2023
medline: 5 1 2024
pubmed: 5 1 2024
entrez: 5 1 2024
Statut: aheadofprint

Résumé

Nine people with cystic fibrosis (pwCF) were found to have isolated elevations in serum total bilirubin after starting elexacaftor/tezacaftor/ivacaftor (ETI) that were associated with Gilbert's Syndrome. In longitudinal examination, total bilirubin levels increased substantially after initiation of ETI without elevations in liver transaminases in those with this syndrome. Because elevated bilirubin levels in Gilbert's Syndrome are benign, ETI was able to be continued in these individuals. Genetic testing for this relatively common syndrome should be strongly considered for pwCF experiencing isolated hyperbilirubinemia after starting ETI, since appropriate diagnosis may help pwCF avoid unnecessary interruption in this therapy with significant health benefits in CF.

Identifiants

pubmed: 38179880
doi: 10.1002/ppul.26831
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : None

Informations de copyright

© 2024 Wiley Periodicals LLC.

Références

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Auteurs

Nidhi Patel (N)

Division of Pulmonary Disease, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Maria Ansar (M)

Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Anh Pham (A)

Division of Pulmonary Disease, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Kelly Thomsen (K)

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Cameron J McKinzie (CJ)

Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.

Deepika Polineni (D)

Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Charles R Esther (CR)

Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Rebekah F Brown (RF)

Department of Pediatrics, Division of Allergy, Immunology and Pulmonary Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Classifications MeSH