Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model.
Endometriosis
Fecundity
Pregnancy
Pregnancy experience
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
05 Jan 2024
05 Jan 2024
Historique:
received:
04
10
2023
accepted:
08
12
2023
medline:
5
1
2024
pubmed:
5
1
2024
entrez:
5
1
2024
Statut:
aheadofprint
Résumé
This study is aimed at identifying variations in the effect of endometriosis on fecundity in a mouse model based on prior pregnancy experience. Endometriosis is one of the most prevalent gynecological diseases and is known to impact female fecundity adversely. In this study, an endometriosis mouse model was established by allografting uterine horn tissue using Pelch's method. The effect of endometriosis on fecundity was confirmed in primiparous and multiparous female mice. As fecundity indicators, the pregnancy rate, number of litters, pregnancy period, and survival rate of the pups were investigated. As a result of the experiment, the pregnancy rate decreased, and the pregnancy period tended to be shorter in primiparous female mice. However, there was no significant change in the multiparous mice. In addition, it has been established that correlations exist between the size of lesions and certain fecundity indicators of the lesion, even among primiparous and multiparous females with endometriosis. The study attempted to demonstrate a link between pregnancy experience and fecundity changes caused by endometriosis by experimentally reproducing clinical results using mouse models. These results suggest strategies for identifying several pathophysiological characteristics of endometriosis.
Identifiants
pubmed: 38180609
doi: 10.1007/s43032-023-01426-2
pii: 10.1007/s43032-023-01426-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korea Health Industry Development Institute
ID : HI22C1424
Pays : Republic of Korea
Organisme : Commercializations Promotion Agency for R and D Outcomes
ID : 1711177795
Informations de copyright
© 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.
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