Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 Jan 2024
05 Jan 2024
Historique:
received:
07
10
2023
accepted:
19
12
2023
medline:
6
1
2024
pubmed:
6
1
2024
entrez:
5
1
2024
Statut:
epublish
Résumé
Thyroid hormones (THs) are important regulators of systemic energy metabolism. In the liver, they stimulate lipid and cholesterol turnover and increase systemic energy bioavailability. It is still unknown how the TH state interacts with the circadian clock, another important regulator of energy metabolism. We addressed this question using a mouse model of hypothyroidism and performed circadian analyses. Low TH levels decreased locomotor activity, food intake, and body temperature mostly in the active phase. Concurrently, liver transcriptome profiling showed only subtle effects compared to elevated TH conditions. Comparative circadian transcriptome profiling revealed alterations in mesor, amplitude, and phase of transcript levels in the livers of low-TH mice. Genes associated with cholesterol uptake, biosynthesis, and bile acid secretion showed reduced mesor. Increased and decreased cholesterol levels in the serum and liver were identified, respectively. Combining data from low- and high-TH conditions allowed the identification of 516 genes with mesor changes as molecular markers of the liver TH state. We explored these genes and created an expression panel that assesses liver TH state in a time-of-day dependent manner. Our findings suggest that the liver has a low TH action under physiological conditions. Circadian profiling reveals genes as potential markers of liver TH state.
Identifiants
pubmed: 38182610
doi: 10.1038/s41598-023-50374-z
pii: 10.1038/s41598-023-50374-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
640Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 353-10/1, GRK-1957, and CRC/TR 296 "LOCOTACT" (ID 424957847, TP13 and TP14)
Organisme : Deutsche Forschungsgemeinschaft
ID : 353-10/1, GRK-1957, and CRC/TR 296 "LOCOTACT" (ID 424957847, TP13 and TP14)
Informations de copyright
© 2024. The Author(s).
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