Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe.
Allogeneic HSCT
HLA DRB1*15 alleles
MAS
Refractory SJIA
SJIA-LD
Journal
Pediatric rheumatology online journal
ISSN: 1546-0096
Titre abrégé: Pediatr Rheumatol Online J
Pays: England
ID NLM: 101248897
Informations de publication
Date de publication:
05 Jan 2024
05 Jan 2024
Historique:
medline:
6
1
2024
pubmed:
6
1
2024
entrez:
5
1
2024
Statut:
epublish
Résumé
It has been increasingly recognized that there is a subset of patients with refractory systemic JIA, who have failed all available medications and may benefit from HSCT. The increasing experience with HSCT in SJIA, suggests that despite the complicated post-HSCT course, short-term, the transplanted patients either achieved SJIA remission or reduced burden of disease. Longer follow-up, however, is needed to better define the long-term outcomes. The discussion at the NextGen 2022 conference was focused on the optimal timing for the procedure, the need for a good control of inflammatory SJIA activity prior to HSCT, and the role of the reduced intensity conditioning regimens as there was a remote concern that such regimens might increase the risk of SJIA relapse after the transplantation. There was unanimous agreement about the importance of long-term registries to address these questions.
Identifiants
pubmed: 38183096
doi: 10.1186/s12969-023-00868-x
pii: 10.1186/s12969-023-00868-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
86Informations de copyright
© 2023. The Author(s).
Références
Kimura Y, Weiss JE, Haroldson KL, Lee T, Punaro M, Oliveira S, Rabinovich E, Riebschleger M, Antón J, Blier PR, Gerloni V, Hazen MM, Kessler E, Onel K, Passo MH, Rennebohm RM, Wallace CA, Woo P, Wulffraat N. Pulmonary hypertension and other potentially fatal pulmonary complications in systemic juvenile idiopathic arthritis. Arthritis Care Res. 2013;65(5):745–52. & Childhood Arthritis Rheumatology Research Alliance Carra Net Investigators
doi: 10.1002/acr.21889
Saper VE, Ombrello MJ, Tremoulet AH, Consortium INCHARGE, et al. Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles Annals of the. Rheumatic Dis. 2022;81:406–15.
doi: 10.1136/annrheumdis-2021-220578
Schulert GS, Yasin S, Carey B, Chalk C, Do T, Schapiro AH, Husami A, Watts A, Brunner HI, Huggins J, Mellins ED, Morgan EM, Ting T, Trapnell BC, Wikenheiser-Brokamp KA, Towe C, Grom AA. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: characterization and risk factors. Arthritis & rheumatology. 2019;71:1943–54 (Hoboken, N.J.). 11.
doi: 10.1002/art.41073
Delemarre E, Roord S, Wulffraat N, van Wijk F, Prakken B. Restoration of the immune balance by autologous bone marrow transplantation in juvenile idiopathic arthritis. Curr Stem Cell Res Therapy. 2011;6(1):3–9.
doi: 10.2174/157488811794480726
Wu Q, Pesenacker AM, Stansfield A, King D, Barge D, Foster HE, Abinun M, Wedderburn LR. Immunological characteristics and T-cell receptor clonal diversity in children with systemic juvenile idiopathic arthritis undergoing T-cell-depleted autologous stem cell transplantation. Immunology. 2014;142(2):227–36.
doi: 10.1111/imm.12245
pubmed: 24405357
pmcid: 4008230
Silva JMF, Ladomenou F, Carpenter B, Chandra S, Sedlacek P, Formankova R, Grandage V, Friswell M, Cant AJ, Nademi Z, Slatter MA, Gennery AR, Hambleton S, Flood TJ, Lucchini G, Chiesa R, Rao K, Amrolia PJ, Brogan P, Wedderburn LR, Glanville JM, Hough R, Marsh R, Abinun M, Veys P. Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis. Blood Adv. 2018;2(7):777–86.
doi: 10.1182/bloodadvances.2017014449
Morelle G, Castelle M, Pinto G, et al. Sustained remission after haploidentical bone marrow transplantation in a child with refractory systemic juvenile idiopathic arthritis. Pediatr Rheumatol. 2021;19:27.
doi: 10.1186/s12969-021-00523-3
Davidson N, Rangarajan HG, Driest K, Bajwa RPS, Polishchuk V, Abu-Arja RF. Allogeneic Hematopoietic Cell Transplant for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome, Case Reports in Rheumatology, vol. 2021, Article ID 9323141, 3 pages, 2021.
Abinun M, Slatter MA. Haematopoietic stem cell transplantation in paediatric rheumatic disease. Curr Opin Rheumatol. 2021;33(5):387–97. https://doi.org/10.1097/BOR.0000000000000823 . PMID: 34261117.
doi: 10.1097/BOR.0000000000000823
pubmed: 34261117