Prevalence of acute periapical abscesses in head and neck cancer patients receiving radiotherapy.
Abscess
Cancer
Dental Abscess
Head & Neck Cancer
Oropharynx
Periapical Abscess
Radiotherapy
Journal
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
ISSN: 1754-4505
Titre abrégé: Spec Care Dentist
Pays: United States
ID NLM: 8103755
Informations de publication
Date de publication:
05 Jan 2024
05 Jan 2024
Historique:
revised:
05
12
2023
received:
07
08
2023
accepted:
11
12
2023
medline:
6
1
2024
pubmed:
6
1
2024
entrez:
5
1
2024
Statut:
aheadofprint
Résumé
Head and neck cancer is a serious condition affecting the life of patients. Radiotherapy is commonly used to treat such conditions. The aim of this study was to assess the prevalence of acute periapical abscesses (PAs) in patients who received radiotherapy for head and neck cancer. Data on acute PAs and oropharyngeal cancer (OPC) diagnosis with or without a history of radiation therapy (RAD) was retrieved by searching the appropriate query in the database. All cases were diagnosed for acute PAs by calibrated dentists for patients admitted to urgent care. The odds ratio (OR) for the prevalence of acute PAs and its association with a history of OPC with or without RAD were then calculated. Adjustment for comorbidities such as diabetes, smoking and gingival and periodontal diseases was also done. The prevalence of acute PAs in patients with a history of OPC was significantly higher as compared to the general hospital patient population (OR 2.92, 95%CI, p < .0001). Males were more affected than females and whites were more affected than African Americans and other ethnicities. The prevalence for PAs in patients with a history of OPC and RAD was higher and the difference in prevalence was statistically significant (OR 3.61, 95%CI, p < .0001). Whites were more affected than African Americans by more than 3.5-fold. Adjustment for diabetes comorbidly affected mainly the OPC + RAD group, however, the difference remained statistically significant. Adjustment for smoking and gingival and periodontal disease reduced the OR but the difference remained statistically different. The high prevalence of acute PAs in patients with a history of OPC and RAD may suggest an association between these conditions warranting a meticulous medical and dental examination.
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2024 The Authors. Special Care in Dentistry published by Special Care Dentistry Association and Wiley Periodicals LLC.
Références
Lo Nigro C, Denaro N, Merlotti A, Merlano M. Head and neck cancer: improving outcomes with a multidisciplinary approach. Cancer Manag Res. 2017;9:363-371.
Guo K, Xiao W, Chen X, Zhao Z, Lin Y, Chen G. Epidemiological trends of head and neck cancer: a population-based study. Biomed Res Int. 2021;2021:1738932.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71:7-33.
Sarode G, Maniyar N, Sarode SC, Jafer M, Patil S, Awan KH. Epidemiologic aspects of oral cancer. Dis Mon. 2020;66:100988.
Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H. Radiation-related damage to dentition. Lancet Oncol. 2006;7:326-335.
Knowles JC, Chalian VA, Shidnia H. Pulp innervation after radiation therapy. J Prosthet Dent. 1986;56:708-711.
Sroussi HY, Epstein JB, Bensadoun RJ, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6:2918-2931.
Moore C, McLister C, Cardwell C, O'Neill C, Donnelly M, McKenna G. Dental caries following radiotherapy for head and neck cancer: a systematic review. Oral Oncol. 2020;100:104484.
Chopra A, Monga N, Sharma S, Kumar V, Chawla A, Logani A. Indices for the assessment of radiation-related caries. J Conserv Dent. 2022;25:481-486
Weissheimer T, Só BB, Pradebon MC, de Figueiredo JAP, Martins MD, Só MVR. Head and neck radiotherapy effects on the dental pulp vitality and response to sensitivity tests: a systematic review with meta-analysis. Int Endod J. 2022;55:563-578
Kataoka SH, Setzer FC, Gondim-Junior E, et al. Late effects of head and neck radiotherapy on pulp vitality assessed by pulse oximetry. J Endod. 2016;42:886-889.
Madani ZS, Azarakhsh S, Shakib PA, Karimi M. Histopathological changes in dental pulp of rats following radiotherapy. Dent Res J (Isfahan). 2017;14:19-24.
Kojima Y, Otsuru M, Hasegawa T, et al. Risk factors for osteoradionecrosis of the jaw in patients with oral or oropharyngeal cancer: verification of the effect of tooth extraction before radiotherapy using propensity score matching analysis. J Dent Sci. 2022;17:1024-1029.
Psyrri A, Prezas L, Burtness B. Oropharyngeal cancer. Clin Adv Hematol Oncol. 2008;6:604-612.
Fossum CC, Chintakuntlawar AV, Price DL, Garcia JJ. Characterization of the oropharynx: anatomy, histology, immunology, squamous cell carcinoma and surgical resection. Histopathology. 2017;70:1021-1029.
Jamal Z, Anjum F, Oropharyngeal squamous cell carcinoma. 2022 Sep 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022
Rotstein I, Katz J. Prevalence of periapical pathosis in smokers versus nonsmokers: a cross-sectional study. Calif Dent Assoc J. 2021;49:487-492.
Kojima Y, Yanamoto S, Umeda M, et al. Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:139-145.
Rahman N, Khan R, Badshah S. Effect of X-rays and gamma radiations on the bone mechanical properties: literature review. Cell Tissue Bank. 2018;19(4):457-472.
Padala SR, Kashyap B, Dekker H, et al. Irradiation affects the structural, cellular and molecular components of jawbones. Int J Radiat Biol. 2022;98:136-147.
Holland R, Gomes JEF, Cintra LTA, Queiroz ÍOA, Estrela C. Factors affecting the periapical healing process of endodontically treated teeth. J Appl Oral Sci. 2017;25:465-476.
Gupta N, Grewal MS, Gairola M, Grewal S, Ahlawat P. Dental pulp status of posterior teeth in patients with oral and oropharyngeal cancer treated with radiotherapy: 1-year follow-up. J Endod. 2018;44:549-554.
van Rijn-Dekker MI, van Luijk P, Schuit E, van der Schaaf A, Langendijk JA, Steenbakkers RJHM. Prediction of radiation-induced parotid gland-related xerostomia in patients with head and neck cancer: regeneration-weighted dose. Int J Radiat Oncol Biol Phys. 2023;117:750-762
Saleh W, Xue W, Katz J. Diabetes mellitus and periapical abscess: a cross-sectional study. J Endod. 2020;46:1605-1609