Physical late effects of treatment among survivors of childhood cancer in low- and middle-income countries: a systematic review.
Childhood cancer
Late effects of cancer treatment
Physical health
Survivorship
Journal
Journal of cancer survivorship : research and practice
ISSN: 1932-2267
Titre abrégé: J Cancer Surviv
Pays: United States
ID NLM: 101307557
Informations de publication
Date de publication:
06 Jan 2024
06 Jan 2024
Historique:
received:
11
09
2023
accepted:
18
12
2023
medline:
7
1
2024
pubmed:
7
1
2024
entrez:
6
1
2024
Statut:
aheadofprint
Résumé
Physical late effects of treatment are well-documented among childhood cancer survivors in high-income countries, but whether prevalence and risk factors are comparable in low- and middle-income countries (LMICs) is unclear. We conducted a systematic review to assess physical late effect outcomes among childhood cancer survivors in LMICs. Five health sciences databases were searched from inception to November 2022 in all languages. We included observational studies conducted in LMICs that evaluated physical late effects of treatment in childhood cancer survivors. Mean or median cohort follow-up must have been ≥ 5 years from original cancer diagnosis. Sixteen full articles and five conference abstracts were included. Studies were conducted in lower-middle (n = 12, 57%) or upper-middle income (n = 9, 43%) countries; nearly half (n = 9, 43%) were conducted in India. Five cohorts (24%) were comprised entirely of 5-year survivors. Subsequent malignant neoplasms were reported in 0-11% of survivors (n = 10 studies). Hypothyroidism and metabolic syndrome prevalence ranged from 2-49% (n = 4 studies) and 4-17% (n = 5 studies), respectively. Gonadal dysfunction ranged from 3-47% (n = 4 studies). Cardiac dysfunction ranged from 1-16% (n = 3 studies). Late effects of the musculoskeletal and urinary systems were least investigated. Substantial knowledge gaps exist in LMIC childhood cancer survivorship. No low-income country data were found. In middle-income countries, late effects were defined and assessed variably and limited by selection bias and small sample sizes. Survivors in LMICs can experience physical late effects of treatment, though additionally systematically collected data from survivor cohorts are needed to fill knowledge gaps.
Identifiants
pubmed: 38183576
doi: 10.1007/s11764-023-01517-8
pii: 10.1007/s11764-023-01517-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Smith M, Hare ML. An overview of progress in childhood cancer survival. J Pediatr Oncol Nurs. 2004;21(3):160–4. https://doi.org/10.1177/1043454204264407 .
doi: 10.1177/1043454204264407
pubmed: 15296046
Aziz NM, Rowland JH. Trends and advances in cancer survivorship research: challenge and opportunity. Semin Radiat Oncol. 2003;13(3):248–66. https://doi.org/10.1016/S1053-4296(03)00024-9 .
doi: 10.1016/S1053-4296(03)00024-9
pubmed: 12903014
Dixon SB, Chow EJ, Hjorth L, Hudson MM, Kremer LCM, Morton LM, et al. The future of childhood cancer survivorship: challenges and opportunities for continued progress. Pediatr Clin North Am. 2020;67(6):1237–51. https://doi.org/10.1016/j.pcl.2020.07.013 .
doi: 10.1016/j.pcl.2020.07.013
pubmed: 33131544
pmcid: 7773506
Altena R, Hubbert L, Kiani NA, Wengström Y, Bergh J, Hedayati E. Evidence-based prediction and prevention of cardiovascular morbidity in adults treated for cancer. Cardio-Oncol. 2021;7(1):20. https://doi.org/10.1186/s40959-021-00105-y .
doi: 10.1186/s40959-021-00105-y
Gibson TM, Robison LL. Impact of cancer therapy-related exposures on late mortality in childhood cancer survivors. Chem Res Toxicol. 2015;28(1):31–7. https://doi.org/10.1021/tx500374k .
doi: 10.1021/tx500374k
pubmed: 25474125
Eiser C. Practitioner review: long-term consequences of childhood cancer. J Child Psychol Psych. 1998;39(5):621–33.
Gupta S, Howard SC, Hunger SP, Antillon FG, Metzger ML, Israels T, et al. Treating Childhood Cancer in Low- and Middle-Income Countries. In: Gelband H, Jha P, Sankaranarayanan R, Horton S, editors. Cancer: disease control priorities, Third Edition (Volume 3). Washington (DC): The International Bank for Reconstruction and Development / The World Bank © 2015 International Bank for Reconstruction and Development / The World Bank.; 2015. https://doi.org/10.1596/978-1-4648-0349-9_ch7
Atun R, Bhakta N, Denburg A, Frazier AL, Friedrich P, Gupta S, et al. Sustainable care for children with cancer: a Lancet Oncology Commission. Lancet Oncol. 2020;21(4):e185–224. https://doi.org/10.1016/s1470-2045(20)30022-x .
doi: 10.1016/s1470-2045(20)30022-x
pubmed: 32240612
Lam CG, Howard SC, Bouffet E, Pritchard-Jones K. Science and health for all children with cancer. Sci. 2019;363(6432):1182–6. https://doi.org/10.1126/science.aaw4892 .
doi: 10.1126/science.aaw4892
Howard SC, Zaidi A, Cao X, Weil O, Bey P, Patte C, et al. The My Child Matters programme: effect of public-private partnerships on paediatric cancer care in low-income and middle-income countries. Lancet Oncol. 2018;19(5):e252–66. https://doi.org/10.1016/s1470-2045(18)30123-2 .
doi: 10.1016/s1470-2045(18)30123-2
pubmed: 29726390
Ward ZJ, Yeh JM, Bhakta N, Frazier AL, Girardi F, Atun R. Global childhood cancer survival estimates and priority-setting: a simulation-based analysis. Lancet Oncol. 2019;20(7):972–83. https://doi.org/10.1016/s1470-2045(19)30273-6 .
doi: 10.1016/s1470-2045(19)30273-6
pubmed: 31129029
Erdmann F, Frederiksen LE, Bonaventure A, Mader L, Hasle H, Robison LL, et al. Childhood cancer: survival, treatment modalities, late effects and improvements over time. Cancer Epidemiol. 2021;71: 101733. https://doi.org/10.1016/j.canep.2020.101733 .
doi: 10.1016/j.canep.2020.101733
pubmed: 32461035
Howard SC, Metzger ML, Wilimas JA, Quintana Y, Pui CH, Robison LL, et al. Childhood cancer epidemiology in low-income countries. Cancer. 2008;112(3):461–72. https://doi.org/10.1002/cncr.23205 .
doi: 10.1002/cncr.23205
pubmed: 18072274
Pramesh CS, Badwe RA, Bhoo-Pathy N, Booth CM, Chinnaswamy G, Dare AJ, et al. Priorities for cancer research in low- and middle-income countries: a global perspective. Nat Med. 2022;28(4):649–57. https://doi.org/10.1038/s41591-022-01738-x .
doi: 10.1038/s41591-022-01738-x
pubmed: 35440716
pmcid: 9108683
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372: n71. https://doi.org/10.1136/bmj.n71 .
doi: 10.1136/bmj.n71
pubmed: 33782057
pmcid: 8005924
World Bank. World Bank Country and Lending Groups. 2021. https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups . Accessed 21 August 2022.
McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012;22(3):276–82.
doi: 10.11613/BM.2012.031
pubmed: 23092060
World Health Organization. World Health Organization countries classification. https://www.who.int/countries . Accessed 11 January 2023.
Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M, et al. Guidance on the conduct of narrative synthesis in systematic reviews. A Prod ESRC Methods Programme Version. 2006;1(1): b92.
PDQ® Pediatric Treatment Editorial Board. PDQ Late Effects of Treatment for Childhood Cancer. Bethesda, MD: National Cancer Institute. Updated 11 September 2023. https://www.cancer.gov/types/childhood-cancers/late-effects-hp-pdq . Accessed 5 Jan 2023.
Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp . Accessed 5 Jan 2023.
Moskalewicz A, Oremus M. No clear choice between Newcastle-Ottawa Scale and appraisal tool for cross-sectional studies to assess methodological quality in cross-sectional studies of health-related quality of life and breast cancer. J Clin Epidemiol. 2020;120:94–103. https://doi.org/10.1016/j.jclinepi.2019.12.013 .
doi: 10.1016/j.jclinepi.2019.12.013
pubmed: 31866469
Losilla JM, Oliveras I, Marin-Garcia JA, Vives J. Three risk of bias tools lead to opposite conclusions in observational research synthesis. J Clin Epidemiol. 2018;101:61–72. https://doi.org/10.1016/j.jclinepi.2018.05.021 .
doi: 10.1016/j.jclinepi.2018.05.021
pubmed: 29864541
Agarwal A, Kapoor G, Jain S, Malhotra P, Sharma A. Metabolic syndrome in childhood cancer survivors: delta BMI a risk factor in lower-middle-income countries. Support Care Cancer. 2022;30(6):5075–83. https://doi.org/10.1007/s00520-022-06910-0 .
doi: 10.1007/s00520-022-06910-0
pubmed: 35217910
Arora PR, Misra R, Mehrotra S, Mittal C, Sharma S, Bagai P, et al. Pilot initiative in India to explore the gonadal function and fertility outcomes of a cohort of childhood cancer survivors. J Hum Reprod Sci. 2016;9(2):90–3. https://doi.org/10.4103/0974-1208.183508 .
doi: 10.4103/0974-1208.183508
pubmed: 27382233
pmcid: 4915292
Bongsebandhu-Phubhakdi C, Wacharasindhu S. Hypothalamic-pituitary axis dysfunction and metabolic derangements in Thai childhood leukemia survivors. Indian J Med Paediatric Oncol. 2020;41(5):688–94. https://doi.org/10.4103/ijmpo.ijmpo_238_19 .
doi: 10.4103/ijmpo.ijmpo_238_19
Castellanos-Toledo A, Nunez-Mondragon JP, De Jesus Figueroa Carbajal J, Cardenas-Cardos R. Frequency of cancer therapy-related late effects among long-term Wilms’ tumor survivors in a 20-year period at the Instituto Nacional de Pediatria, Mexico city, Mexico. Journal of Clinical Oncology Conference. 2018;36(15 Supplement 1). https://doi.org/10.1200/JCO.2018.36.15-suppl.e22508
Das G, Seth R, Ramakrishnan L, Jana M, Jain V, Gupta A, et al. Metabolic syndrome in childhood acute lymphoblastic leukemia/lymphoma survivors: a global cause for concern. Pediatr Blood Cancer. 2022;69(Supplement 5):S482–3. https://doi.org/10.1002/pbc.29952 .
doi: 10.1002/pbc.29952
El-Rashedy FH, El-Hawy MA, El Hefnawy SM, Mohammed MM. Assessment of obesity and hepatic late adverse effects in the Egyptian survivors of pediatric acute lymphoblastic leukemia: a single center study. Mediterr J Hematol Infect Dis. 2017;9(1): e2017026. https://doi.org/10.4084/mjhid.2017.026 .
doi: 10.4084/mjhid.2017.026
pubmed: 28512555
pmcid: 5419197
Godoy-Casasbuenas N, de Vries E. Self-reported health problems and quality of life in a sample of Colombian childhood cancer survivors: a descriptive cross-sectional study. Cancers (Basel). 2022;14(12). https://doi.org/10.3390/cancers14122999
Hesseling PB, Afungchwi GM, Dip VN, Kruger M, Dip CK, Nfor P, et al. Burkitt lymphoma: age specific fertility rate in 113 long-term female survivors after treatment with cyclophosphamide. J Trop Pediatr. 2021;67(1). https://doi.org/10.1093/tropej/fmab004
Jiménez-Carbajal MG, Antúnez-Sánchez SP, Arreguín-González FE, Benito-Reséndiz AE. Cardiovascular evaluation of patients undergoing cancer treatments at a clinic for childhood cancer survivors in Mexico. Arch Cardiol Mex. 2020;91(1):25–33. https://doi.org/10.24875/acm.20000401 .
doi: 10.24875/acm.20000401
pubmed: 33008156
pmcid: 8258914
Kurkure P, Achrekar S, Dalvi N, Goswami S. Childhood cancer survivors–living beyond cure. Indian J Pediatr. 2003;70(10):825–8. https://doi.org/10.1007/bf02723807 .
doi: 10.1007/bf02723807
pubmed: 14649480
Malhotra P, Kapoor G, Jain S, Sharma R. Impairment of lung diffusion capacity in survivors if childhood cancer: a single centre study from a low and middle income country. Pediatric Blood and Cancer Conference: 53rd Annual Congress of the International Society of Paediatric Oncology, SIOP. 2021;68(SUPPL 5). https://doi.org/10.1002/pbc.29349
Marinho DH, Ribeiro LL, Nichele S, Loth G, Koliski A, Mousquer RTG, et al. The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: a single-center report from Brazil. Pediatr Transplant. 2020;24(4): e13691. https://doi.org/10.1111/petr.13691 .
doi: 10.1111/petr.13691
pubmed: 32246550
Martins R, Reis M, Bernardes J, Tone L, Scrideli C. Late effects of childhood cancer treatment in Brazilian survivors. Pediatr Blood Cancer. 2022;69(Supplement 5):S635. https://doi.org/10.1002/pbc.299522 .
doi: 10.1002/pbc.299522
Prasad M, Chinnaswamy G, Vora T, Goswami S. Burden of late effects and challenges faced in the long-term follow-up of paediatric germ cell tumour survivors: a report from India. Eur Urol Suppl. 2019;18(2):31. https://doi.org/10.1016/S1569-9056%2819%2932544-8 .
doi: 10.1016/S1569-9056%2819%2932544-8
Prasad M, Goswami S, Chinnaswamy G, Banavali SD, Kurkure PA. Long-term outcomes in survivors of childhood cancer: a 30-year experience from India. JCO Glob Oncol. 2022;8: e2200044. https://doi.org/10.1200/go.22.00044 .
doi: 10.1200/go.22.00044
pubmed: 36332172
pmcid: 9668554
Rafsanjani KA, Faranoush M, Hedayatiasl AA, Vossough P. Gonadal function and fertility in male survivors treated for Hodgkin’s disease in Iran. Saudi Med J. 2007;28(11):1690–3.
pubmed: 17965791
Rajendranath R, Veeraiah S, Ramesh A, Sagar TG. Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India. South Asian J Cancer. 2014;3(1):60–5. https://doi.org/10.4103/2278-330x.126529 .
doi: 10.4103/2278-330x.126529
pubmed: 24665450
pmcid: 3961872
Schwartz L. Survival in adolescents and young adults with cancer in childhood. Medicina (B Aires). 2001;61(4):401–5.
pubmed: 11563167
Seth R, Singh A, Seth S, Sapra S. Late effects of treatment in survivors of childhood cancers: a single-centre experience. Indian J Med Res. 2017;146(2):216–23. https://doi.org/10.4103/ijmr.IJMR_196_16 .
doi: 10.4103/ijmr.IJMR_196_16
pubmed: 29265022
pmcid: 5761031
Shimoda S, Horsman J, Furlong W, Barr R, de Camargo B. Disability and health-related quality of life in long-term survivors of cancer in childhood in Brazil. J Pediatr Hematol Oncol. 2008;30(8):563–70. https://doi.org/10.1097/MPH.0b013e31816e231c .
doi: 10.1097/MPH.0b013e31816e231c
pubmed: 18799931
Villanueva G, Sampor C, Moreno F, Alderete D, Moresco A, Pinto N, et al. Subsequent malignant neoplasms in the pediatric age in retinoblastoma survivors in Argentina. Pediatr Blood Cancer. 2022;69(8): e29710. https://doi.org/10.1002/pbc.29710 .
doi: 10.1002/pbc.29710
pubmed: 35451226
Erdmann F, Frederiksen LE, Bonaventure A, Mader L, Hasle H, Robison LL, et al. Childhood cancer: survival, treatment modalities, late effects and improvements over time. Cancer Epidemiol. 2021;71(Pt B): 101733. https://doi.org/10.1016/j.canep.2020.101733 .
doi: 10.1016/j.canep.2020.101733
pubmed: 32461035
Bhakta N, Liu Q, Ness KK, Baassiri M, Eissa H, Yeo F, et al. The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet. 2017;390(10112):2569–82. https://doi.org/10.1016/s0140-6736(17)31610-0 .
doi: 10.1016/s0140-6736(17)31610-0
pubmed: 28890157
pmcid: 5798235
Institute of Medicine (US) and National Research Council (US) National Cancer Policy Board. In: Hewitt M, Weiner SL, Simone JV, editors. Childhood Cancer Survivorship: Improving Care and Quality of Life. Washington (DC): National Academies Press (US). 2003. https://www.ncbi.nlm.nih.gov/books/NBK221742/ . https://doi.org/10.17226/10767 .
Turcotte LM, Liu Q, Yasui Y, Arnold MA, Hammond S, Howell RM, et al. Temporal trends in treatment and subsequent neoplasm risk among 5-year survivors of childhood cancer, 1970–2015. JAMA. 2017;317(8):814–24. https://doi.org/10.1001/jama.2017.0693 .
doi: 10.1001/jama.2017.0693
pubmed: 28245323
pmcid: 5473951
Armstrong GT, Oeffinger KC, Chen Y, Kawashima T, Yasui Y, Leisenring W, et al. Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol. 2013;31(29):3673–80. https://doi.org/10.1200/jco.2013.49.3205 .
doi: 10.1200/jco.2013.49.3205
pubmed: 24002505
pmcid: 3804290
Scholz-Kreisel P, Spix C, Blettner M, Eckerle S, Faber J, Wild P, et al. Prevalence of cardiovascular late sequelae in long-term survivors of childhood cancer: a systematic review and meta-analysis. Pediatr Blood Cancer. 2017;64(7): e26428. https://doi.org/10.1002/pbc.26428 .
doi: 10.1002/pbc.26428
Mulrooney DA, Armstrong GT, Huang S, Ness KK, Ehrhardt MJ, Joshi VM, et al. Cardiac outcomes in adult survivors of childhood cancer exposed to cardiotoxic therapy. Ann Intern Med. 2016;164(2):93–101. https://doi.org/10.7326/m15-0424 .
doi: 10.7326/m15-0424
pubmed: 26747086
pmcid: 4809016
Ness KK, Gurney JG. Adverse late effects of childhood cancer and its treatment on health and performance. Annu Rev Public Health. 2007;28:279–302.
doi: 10.1146/annurev.publhealth.28.021406.144049
pubmed: 17367288
Mertens AC, Yasui Y, Liu Y, Stovall M, Hutchinson R, Ginsberg J, et al. Pulmonary complications in survivors of childhood and adolescent cancer. A report from the childhood cancer survivor study. Cancer. 2002;95(11):2431–41. https://doi.org/10.1002/cncr.10978 .
doi: 10.1002/cncr.10978
pubmed: 12436452
Whelan KF, Stratton K, Kawashima T, Waterbor JW, Castleberry RP, Stovall M, et al. Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor study. Pediatr Blood Cancer. 2010;54(1):103–9. https://doi.org/10.1002/pbc.22277 .
doi: 10.1002/pbc.22277
pubmed: 19774634
pmcid: 2783513
Gawade PL, Hudson MM, Kaste SC, Neglia JP, Wasilewski-Masker K, Constine LS, et al. A systematic review of selected musculoskeletal late effects in survivors of childhood cancer. Curr Pediatr Rev. 2014;10(4):249–62. https://doi.org/10.2174/1573400510666141114223827 .
doi: 10.2174/1573400510666141114223827
pubmed: 25403639
Hudson MM. Reproductive outcomes for survivors of childhood cancer. Obstet Gynecol. 2010;116(5):1171–83. https://doi.org/10.1097/AOG.0b013e3181f87c4b .
doi: 10.1097/AOG.0b013e3181f87c4b
pubmed: 20966703
pmcid: 4729296
Farrag A, Ghazaly MH, Mohammed K, Volland R, Hero B, Berthold F. Comparing presentations and outcomes of children with cancer: a study between a lower-middle-income country and a high-income country. BMC Pediatr. 2023;23(1):443. https://doi.org/10.1186/s12887-023-04214-8 .
doi: 10.1186/s12887-023-04214-8
pubmed: 37670249
pmcid: 10478379
Friedman DL, Whitton J, Leisenring W, Mertens AC, Hammond S, Stovall M, et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the childhood cancer survivor study. J Natl Cancer Inst. 2010;102(14):1083–95. https://doi.org/10.1093/jnci/djq238 .
doi: 10.1093/jnci/djq238
pubmed: 20634481
pmcid: 2907408
Chemaitilly W, Cohen LE, Mostoufi-Moab S, Patterson BC, Simmons JH, Meacham LR, et al. Endocrine late effects in childhood cancer survivors. J Clin Oncol. 2018;36(21):2153–9. https://doi.org/10.1200/jco.2017.76.3268 .
doi: 10.1200/jco.2017.76.3268
pubmed: 29874130
Smith WA, Li C, Nottage KA, Mulrooney DA, Armstrong GT, Lanctot JQ, et al. Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study Cancer. 2014;120(17):2742–50. https://doi.org/10.1002/cncr.28670 .
doi: 10.1002/cncr.28670
pubmed: 25070001
Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS, et al. The childhood cancer survivor study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol. 2009;27(14):2308–18. https://doi.org/10.1200/jco.2009.22.3339 .
doi: 10.1200/jco.2009.22.3339
pubmed: 19364948
pmcid: 2677920
Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li C-K, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14(3):e104–16. https://doi.org/10.1016/S1470-2045(13)70008-1 .
doi: 10.1016/S1470-2045(13)70008-1
pubmed: 23434340
Moten A, Schafer DF, Montgomery E. A prescription for health inequity: building public health infrastructure in resource-poor settings. J Glob Health. 2012;2(2): 020302. https://doi.org/10.7189/jogh.02.020302 .
doi: 10.7189/jogh.02.020302
pubmed: 23289073
pmcid: 3529314
Witter S, Sheikh K, Schleiff M. Learning health systems in low-income and middle-income countries: exploring evidence and expert insights. BMJ Glob Health. 2022;7(Suppl 7). https://doi.org/10.1136/bmjgh-2021-008115
Arora RS, Arora PR, Seth R, Sharma S, Kumar C, Dhamankar V, et al. Childhood cancer survivorship and late effects: the landscape in India in 2020. Pediatr Blood Cancer. 2020;67(9): e28556. https://doi.org/10.1002/pbc.28556 .
doi: 10.1002/pbc.28556
pubmed: 32649000