Possible mechanisms and simulation modeling of FLASH radiotherapy.
FLASH radiotherapy
Reactive species
Simulation modeling
Ultra-high dose rate
Journal
Radiological physics and technology
ISSN: 1865-0341
Titre abrégé: Radiol Phys Technol
Pays: Japan
ID NLM: 101467995
Informations de publication
Date de publication:
06 Jan 2024
06 Jan 2024
Historique:
received:
23
05
2023
accepted:
02
12
2023
revised:
01
12
2023
medline:
7
1
2024
pubmed:
7
1
2024
entrez:
6
1
2024
Statut:
aheadofprint
Résumé
FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It delivers radiation doses at an ultra-high dose rate (UHDR: ≥ 40 Gy/s) in a single instant or a few pulses. Much higher irradiation doses can be administered to tumors with FLASH-RT than with conventional dose rate (0.01-0.40 Gy/s) radiotherapy. UHDR irradiation can suppress toxicity in normal tissues while sustaining antitumor efficiency, which is referred to as the FLASH effect. However, the mechanisms underlying the effects of the FLASH remain unclear. To clarify these mechanisms, the development of simulation models that can contribute to treatment planning for FLASH-RT is still underway. Previous studies indicated that transient oxygen depletion or augmented reactions between secondary reactive species produced by irradiation may be involved in this process. To discuss the possible mechanisms of the FLASH effect and its clinical potential, we summarized the physicochemical, chemical, and biological perspectives as well as the development of simulation modeling for FLASH-RT.
Identifiants
pubmed: 38184508
doi: 10.1007/s12194-023-00770-x
pii: 10.1007/s12194-023-00770-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.
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