Quantitative catalogue of mammalian mitotic chromosome-associated RNAs.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
06 Jan 2024
06 Jan 2024
Historique:
received:
21
08
2023
accepted:
27
12
2023
medline:
7
1
2024
pubmed:
7
1
2024
entrez:
6
1
2024
Statut:
epublish
Résumé
The faithful transmission of a cell's identity and functionality to its daughters during mitosis requires the proper assembly of mitotic chromosomes from interphase chromatin in a process that involves significant changes in the genome-bound material, including the RNA. However, our understanding of the RNA that is associated with the mitotic chromosome is presently limited. Here, we present complete and quantitative characterizations of the full-length mitotic chromosome-associated RNAs (mCARs) for 3 human cell lines, a monkey cell line, and a mouse cell line derived from high-depth RNA sequencing (3 replicates, 47 M mapped read pairs for each replicate). Overall, we identify, on average, more than 20,400 mCAR species per cell-type (including isoforms), more than 5,200 of which are enriched on the chromosome. Notably, overall, more than 2,700 of these mCARs were previously unknown, which thus also expands the annotated genome of these species. We anticipate that these datasets will provide an essential resource for future studies to better understand the functioning of mCARs on the mitotic chromosome and in the cell.
Identifiants
pubmed: 38184632
doi: 10.1038/s41597-023-02884-8
pii: 10.1038/s41597-023-02884-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81627801
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81627801
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81627801
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31971151
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81627801
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81972909
Informations de copyright
© 2024. The Author(s).
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