A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation.

Inward rectifier ROMK channel regulation renal selectivity filter

Journal

Channels (Austin, Tex.)
ISSN: 1933-6969
Titre abrégé: Channels (Austin)
Pays: United States
ID NLM: 101321614

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 7 1 2024
pubmed: 7 1 2024
entrez: 7 1 2024
Statut: ppublish

Résumé

The Kir1.1 (ROMK) family of weak inward rectifiers controls K secretion in the renal CCT and K recycling in the renal TALH. A single point mutant of the inward rectifier, F127V-Kir1.1b was used to investigate the K transition between the selectivity filter and the outer mouth of the channel. We hypothesize that normally an aromatic

Identifiants

DOI: 10.1080/19336950.2023.2294661 PMID: 38184795
pubmed: 38184795
doi: 10.1080/19336950.2023.2294661
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2294661

Auteurs

Henry Sackin (H)

Department of Physiology and Biophysics and Center for Proteomics and Molecular Therapeutics, Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.
ORCID: 0000-0002-2886-9213

Mikheil Nanazashvili (M)

Department of Physiology and Biophysics and Center for Proteomics and Molecular Therapeutics, Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

Classifications MeSH