Application of cognitive remediation in the world: new experiences from two schizophrenia rehabilitation centers in Togo and Benin.

Cognitive remediation Evidence-based Low-income countries Mental health care Psychosocial rehabilitation Schizophrenia

Journal

Social psychiatry and psychiatric epidemiology
ISSN: 1433-9285
Titre abrégé: Soc Psychiatry Psychiatr Epidemiol
Pays: Germany
ID NLM: 8804358

Informations de publication

Date de publication:
07 Jan 2024
Historique:
received: 07 07 2023
accepted: 11 12 2023
medline: 7 1 2024
pubmed: 7 1 2024
entrez: 7 1 2024
Statut: aheadofprint

Résumé

People with schizophrenia in Sub-Saharan Africa often live in very difficult conditions, suffer important social isolation and usually do not receive any kind of treatment. In this context, some non-governmental initiatives have come to light, providing accommodation, food, primary healthcare, medications and, in some cases, education and rehabilitation. The aims of this study were to assess feasibility, effects, and acceptability of a Cognitive Remediation Therapy (CRT) intervention in the particular context of psychiatric rehabilitation in Togo and Benin. Patients diagnosed with schizophrenia accessing the "Saint Camille" association rehabilitation centers in Togo and Benin during the enrollment period were allocated consecutively with a 1:1 proportion to receive a manualized CRT intervention (46 one-hour sessions over 14 weeks) or continuing Treatment As Usual (TAU). The assessment included validated measures of cognitive performance and real-world functioning and was performed at baseline and at the conclusion of treatment. All subjects that were invited into the study agreed to participate and completed the intervention, for a total of 36 participants. CRT produced greater improvements than TAU in processing speed, working memory, verbal memory, cognitive flexibility, and executive functions measures, with moderate to large effect sizes, in particular in processing speed and working memory domains. CRT represents a feasible and effective psychosocial intervention that can be implemented even in contexts with very limited resources, and could represent an important instrument to promote the rehabilitation process of people living with schizophrenia in low-income countries.

Identifiants

pubmed: 38184811
doi: 10.1007/s00127-023-02603-z
pii: 10.1007/s00127-023-02603-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Green MF, Horan WP, Lee J (2019) Nonsocial and social cognition in schizophrenia: current evidence and future directions. World Psychiatry Off J World Psychiatr Assoc WPA 18:146–161. https://doi.org/10.1002/wps.20624
doi: 10.1002/wps.20624
Pinkham AE, Harvey PD, Penn DL (2018) Social cognition psychometric evaluation: results of the final validation study. Schizophr Bull 44:737–748. https://doi.org/10.1093/schbul/sbx117
doi: 10.1093/schbul/sbx117 pubmed: 28981848
Galderisi S, Rossi A, Rocca P et al (2014) The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia. World Psychiatry Off J World Psychiatr Assoc WPA 13:275–287. https://doi.org/10.1002/wps.20167
doi: 10.1002/wps.20167
Harvey PD, Strassnig M (2012) Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status. World Psychiatry Off J World Psychiatr Assoc WPA 11:73–79. https://doi.org/10.1016/j.wpsyc.2012.05.004
doi: 10.1016/j.wpsyc.2012.05.004
Maj M, van Os J, De Hert M et al (2021) The clinical characterization of the patient with primary psychosis aimed at personalization of management. World Psychiatry 20:4–33. https://doi.org/10.1002/wps.20809
doi: 10.1002/wps.20809 pubmed: 33432763 pmcid: 7801854
Charlson FJ, Ferrari AJ, Santomauro DF et al (2018) Global epidemiology and burden of Schizophrenia: findings from the global burden of disease study 2016. Schizophr Bull 44:1195–1203. https://doi.org/10.1093/schbul/sby058
doi: 10.1093/schbul/sby058 pubmed: 29762765 pmcid: 6192504
McGrath J, Saha S, Chant D, Welham J (2008) Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev 30:67–76. https://doi.org/10.1093/epirev/mxn001
doi: 10.1093/epirev/mxn001 pubmed: 18480098
Saha S, Chant D, Welham J, McGrath J (2005) A systematic review of the prevalence of schizophrenia. PLOS Med 2:e141. https://doi.org/10.1371/journal.pmed.0020141
doi: 10.1371/journal.pmed.0020141 pubmed: 15916472 pmcid: 1140952
Chidarikire S, Cross M, Skinner I, Cleary M (2018) Treatments for people living with schizophrenia in sub-Saharan Africa: an adapted realist review. Int Nurs Rev 65:78–92. https://doi.org/10.1111/inr.12391
doi: 10.1111/inr.12391 pubmed: 28543089
Essien B, Asamoah MK (2020) Reviewing the common barriers to the mental healthcare delivery in africa. J Relig Health 59:2531–2555. https://doi.org/10.1007/s10943-020-01059-8
doi: 10.1007/s10943-020-01059-8 pubmed: 32691189
Kisely S, Siskind D (2019) Meeting the mental health needs of low- and middle-income countries the start of a long journey. BJPsych Open. https://doi.org/10.1192/bjo.2019.86
doi: 10.1192/bjo.2019.86 pubmed: 31727201 pmcid: 6949535
Angermeyer MC, Carta MG, Matschinger H et al (2016) Cultural differences in stigma surrounding schizophrenia: comparison between Central Europe and North Africa. Br J Psychiatry 208:389–397. https://doi.org/10.1192/bjp.bp.114.154260
doi: 10.1192/bjp.bp.114.154260 pubmed: 26585098
Assefa D, Shibre T, Asher L, Fekadu A (2012) Internalized stigma among patients with schizophrenia in Ethiopia: a cross-sectional facility-based study. BMC Psychiatry 12:239. https://doi.org/10.1186/1471-244X-12-239
doi: 10.1186/1471-244X-12-239 pubmed: 23272796 pmcid: 3544560
Bifftu BB, Dachew BA, Tiruneh BT (2015) Perceived stigma and associated factors among people with epilepsy at Gondar University Hospital, Northwest Ethiopia: a cross-sectional institution based study. Afr Health Sci 15:1211–1219. https://doi.org/10.4314/ahs.v15i4.21
doi: 10.4314/ahs.v15i4.21 pubmed: 26958023 pmcid: 4765415
Ahongbonon G (2020) La maladie mentale en Afrique. Santé Mentale en Afrique de l’Ouest, Lomé, Togo
Vita A, Kakli M, Barlati S et al (2023) Implementation of cognitive rehabilitation interventions for schizophrenia in low-income countries: an experience from Togo and Benin. Int J Soc Psychiatry. https://doi.org/10.1177/00207640231181526
doi: 10.1177/00207640231181526 pubmed: 37329184
Saxena S, Funk M, Chisholm D (2013) World Health Assembly adopts Comprehensive Mental Health Action Plan 2013–2020. The Lancet 381:1970–1971. https://doi.org/10.1016/S0140-6736(13)61139-3
doi: 10.1016/S0140-6736(13)61139-3
World Health Organization (2013) Mental Health Action Plan 2013–2020. World Health Organization, Geneva, Switzerland
United Nations (2019) World population prospects 2019. United Nations Department of Economic and Social Affairs, Population Division New York, NY
doi: 10.18356/13bf5476-en
Sorketti EA, Zainal NZ, Habil MH (2013) The treatment outcome of psychotic disorders by traditional healers in central Sudan. Int J Soc Psychiatry 59:365–376. https://doi.org/10.1177/0020764012437651
doi: 10.1177/0020764012437651 pubmed: 22433242
Lejeune JA, Northrop A, Kurtz MM (2021) A meta-analysis of cognitive remediation for schizophrenia: efficacy and the role of participant and treatment factors. Schizophr Bull 47:997–1006. https://doi.org/10.1093/schbul/sbab022
doi: 10.1093/schbul/sbab022 pubmed: 33772310 pmcid: 8266668
van Duin D, de Winter L, Oud M et al (2019) The effect of rehabilitation combined with cognitive remediation on functioning in persons with severe mental illness: systematic review and meta-analysis. Psychol Med 49:1414–1425. https://doi.org/10.1017/S003329171800418X
doi: 10.1017/S003329171800418X pubmed: 30696500
Vita A, Gaebel W, Mucci A et al (2022) European psychiatric association guidance on treatment of cognitive impairment in schizophrenia. Eur Psychiatry 65:e57. https://doi.org/10.1192/j.eurpsy.2022.2315
doi: 10.1192/j.eurpsy.2022.2315 pubmed: 36059103 pmcid: 9532218
Wykes T, Huddy V, Cellard C et al (2011) A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry 168:472–485. https://doi.org/10.1176/appi.ajp.2010.10060855
doi: 10.1176/appi.ajp.2010.10060855 pubmed: 21406461
Vita A, Barlati S, Ceraso A et al (2022) Acceptability of cognitive remediation for schizophrenia a systematic review and meta-analysis of randomized controlled trials. Psychol Med. https://doi.org/10.1017/S0033291722000319
doi: 10.1017/S0033291722000319 pubmed: 36217912 pmcid: 10277755
Garrido G, Penadés R, Barrios M et al (2017) Computer-assisted cognitive remediation therapy in schizophrenia: Durability of the effects and cost-utility analysis. Psychiatry Res 254:198–204. https://doi.org/10.1016/j.psychres.2017.04.065
doi: 10.1016/j.psychres.2017.04.065 pubmed: 28463718
Reeder C, Pile V, Crawford P et al (2016) The feasibility and acceptability to service users of CIRCuiTS, a computerized cognitive remediation therapy programme for schizophrenia. Behav Cogn Psychother 44:288–305. https://doi.org/10.1017/S1352465815000168
doi: 10.1017/S1352465815000168 pubmed: 26004421
Vita A, Barlati S, Ceraso A et al (2021) Effectiveness, core elements, and moderators of response of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiat 78:848–858. https://doi.org/10.1001/jamapsychiatry.2021.0620
doi: 10.1001/jamapsychiatry.2021.0620
Cella M, Price T, Corboy H et al (2020) Cognitive remediation for inpatients with psychosis: a systematic review and meta-analysis. Psychol Med 50:1062–1076. https://doi.org/10.1017/S0033291720000872
doi: 10.1017/S0033291720000872 pubmed: 32349802
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, DSM-5, 5th edn. American Psychiatric Publishing, Arlington, VA
doi: 10.1176/appi.books.9780890425596
Delahunty A, Reeder C, Wykes T, et al (2002) Revised cognitive remediation therapy manual. Institute of Psychiatry, London, United Kingdom
Penadés R, Catalán R, Salamero M et al (2006) Cognitive remediation therapy for outpatients with chronic schizophrenia: a controlled and randomized study. Schizophr Res 87:323–331. https://doi.org/10.1016/j.schres.2006.04.019
doi: 10.1016/j.schres.2006.04.019 pubmed: 16750611
Wykes T, Reeder C, Landau S et al (2007) Cognitive remediation therapy in schizophrenia: randomised controlled trial. Br J Psychiatry J Ment Sci 190:421–427. https://doi.org/10.1192/bjp.bp.106.026575
doi: 10.1192/bjp.bp.106.026575
Reitan RM (1958) Validity of the Trail Making Test as an Indicator of Organic Brain Damage. Percept Mot Skills 8:271–276 https://doi.org/10.2466/pms.1958.8.3.271
doi: 10.2466/pms.1958.8.3.271
Wechsler D (1981) WAIS-R: Wechsler adult intelligence scale-revised manual. The Psychological Corporation, New York, NY
Bean J (2011) Rey Auditory Verbal Learning Test, Rey AVLT. In: Kreutzer JS, DeLuca J, Caplan B (eds) Encyclopedia of clinical neuropsychology. Springer, New York, NY, pp 2174–2175
doi: 10.1007/978-0-387-79948-3_1153
Fusar-Poli P, Deste G, Smieskova R et al (2012) Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry 69:562–571. https://doi.org/10.1001/archgenpsychiatry.2011.1592
doi: 10.1001/archgenpsychiatry.2011.1592 pubmed: 22664547
Jones SH, Thornicroft G, Coffey M, Dunn G (1995) A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). Br J Psychiatry J Ment Sci 166:654–659. https://doi.org/10.1192/bjp.166.5.654
doi: 10.1192/bjp.166.5.654
American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders. Text Revision (DSM-IV-TR), 4th edn. American Psychiatric Association, Washington, DC
Carlson KD, Schmidt FL (1999) Impact of experimental design on effect size: Findings from the research literature on training. J Appl Psychol 84:851–862. https://doi.org/10.1037/0021-9010.84.6.851
doi: 10.1037/0021-9010.84.6.851
Bowie CR, Bell MD, Fiszdon JM et al (2020) Cognitive remediation for schizophrenia: an expert working group white paper on core techniques. Schizophr Res 215:49–53. https://doi.org/10.1016/j.schres.2019.10.047
doi: 10.1016/j.schres.2019.10.047 pubmed: 31699627
Deste G, Corbo D, Nibbio G et al (2023) Impact of physical exercise alone or in combination with cognitive remediation on cognitive functions in people with schizophrenia: a qualitative critical review. Brain Sci 13:320. https://doi.org/10.3390/brainsci13020320
doi: 10.3390/brainsci13020320 pubmed: 36831863 pmcid: 9954055
Montemagni C, Del Favero E, Riccardi C et al (2021) Effects of cognitive remediation on cognition, metacognition, and social cognition in patients with schizophrenia. Front Psychiatry 12:649737. https://doi.org/10.3389/fpsyt.2021.649737
doi: 10.3389/fpsyt.2021.649737 pubmed: 34305668 pmcid: 8299002
Nibbio G, Barlati S, Cacciani P et al (2020) Evidence-based integrated intervention in patients with schizophrenia: a pilot study of feasibility and effectiveness in a real-world rehabilitation setting. Int J Environ Res Public Health 17:E3352. https://doi.org/10.3390/ijerph17103352
doi: 10.3390/ijerph17103352
Kambeitz-Ilankovic L, Betz LT, Dominke C et al (2019) Multi-outcome meta-analysis (MOMA) of cognitive remediation in schizophrenia: revisiting the relevance of human coaching and elucidating interplay between multiple outcomes. Neurosci Biobehav Rev 107:828–845. https://doi.org/10.1016/j.neubiorev.2019.09.031
doi: 10.1016/j.neubiorev.2019.09.031 pubmed: 31557548 pmcid: 8942567
Bell MD, Choi K-H, Dyer C, Wexler BE (2014) Benefits of cognitive remediation and supported employment for schizophrenia patients with poor community functioning. Psychiatr Serv 65:469–475. https://doi.org/10.1176/appi.ps.201200505
doi: 10.1176/appi.ps.201200505 pubmed: 24382594
McGurk SR, Mueser KT, Xie H et al (2016) Cognitive remediation for vocational rehabilitation nonresponders. Schizophr Res 175:48–56. https://doi.org/10.1016/j.schres.2016.04.045
doi: 10.1016/j.schres.2016.04.045 pubmed: 27209526
Bryce S, Warren N, Ponsford J et al (2018) Understanding the lived experience of cognitive remediation in schizophrenia: a qualitative comparison with an active control. Psychiatr Rehabil J 41:302–311. https://doi.org/10.1037/prj0000309
doi: 10.1037/prj0000309 pubmed: 30010356
Medalia A, Erlich MD, Soumet-Leman C, Saperstein AM (2019) Translating cognitive behavioral interventions from bench to bedside: The feasibility and acceptability of cognitive remediation in research as compared to clinical settings. Schizophr Res 203:49–54. https://doi.org/10.1016/j.schres.2017.07.044
doi: 10.1016/j.schres.2017.07.044 pubmed: 28768601

Auteurs

Giacomo Deste (G)

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.

Mawuko Kakli (M)

Association Saint Camille de Lellis, Lomé, Togo.
Diocese of Aného, Aného, Togo.

Stefano Barlati (S)

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.

Gabriele Nibbio (G)

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy. gabriele.nibbio@gmail.com.

Pacôme Dossou (P)

Association Saint Camille de Lellis, Lomé, Togo.

Salomon Léonard Degila (SL)

Association Saint Camille de Lellis, Lomé, Togo.

Anna Ceraso (A)

Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.

Jacopo Lisoni (J)

Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.

Irene Calzavara-Pinton (I)

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.

Simona Villa (S)

Congregation "Suore Misericordine" mission in Fatebenefratelli Hospital of Afagnan, Afanyagan, Togo.

Antonio Vita (A)

Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
Department of Mental Health and Addiction Services, ASST Spedali Civili of Brescia, Brescia, Italy.

Classifications MeSH