How real-world data can facilitate the development of precision medicine treatment in psychiatry.

Drug treatment outcomes Genomics Precision medicine Prediction algorithms Psychiatry Real-world data

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
05 Jan 2024
Historique:
received: 08 08 2023
revised: 20 12 2023
accepted: 02 01 2024
medline: 8 1 2024
pubmed: 8 1 2024
entrez: 7 1 2024
Statut: aheadofprint

Résumé

Precision medicine has the ambition to improve treatment response and clinical outcomes through patient stratification, and holds great potential in mental disorders. However, several important factors are needed to transform current practice into a "precision psychiatry" framework. Most important are (1) the generation of accessible large real-world training and test data including genomic data integrated from multiple sources, (2) the development and validation of advanced analytical tools for stratification and prediction, and (3) the development of clinically useful management platforms for patient monitoring that can be integrated into healthcare systems in real-life settings. This narrative review summarizes strategies for obtaining the key elements - well-powered samples from large biobanks, integrated with electronic health records and health registry data using novel artificial intelligence algorithms - to predict outcomes in severe mental disorders and translate these models into clinical management and treatment approaches. Key elements are massive mental health data and novel artificial intelligence algorithms. For the clinical translation of these strategies, we discuss a precision medicine platform for improved management of mental disorders. We include use cases to illustrate how precision medicine interventions could be brought into psychiatry to improve the clinical outcomes of mental disorders.

Identifiants

DOI: 10.1016/j.biopsych.2024.01.001 PMID: 38185234
pubmed: 38185234
pii: S0006-3223(24)00003-9
doi: 10.1016/j.biopsych.2024.01.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Elise Koch (E)

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: e.m.koch@medisin.uio.no.

Antonio F Pardiñas (AF)

Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Kevin S O'Connell (KS)

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Pierluigi Selvaggi (P)

Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.

José Camacho Collados (JC)

CardiffNLP, School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom.

Aleksandar Babic (A)

DNV, Oslo, Norway.

Serena E Marshall (SE)

DNV, Oslo, Norway.

Erik Van der Eycken (E)

GAMIAN-Europe, Brussels, Belgium.

Cecilia Angulo (C)

GAMIAN-Europe, Brussels, Belgium.

Yi Lu (Y)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

Patrick F Sullivan (PF)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA.

Anders M Dale (AM)

Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA 92093, USA;; Departments of Radiology, Psychiatry, Neurosciences, University of California, San Diego, La Jolla, CA92093, USA.

Espen Molden (E)

Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

Danielle Posthuma (D)

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Nathan White (N)

CorTechs Labs, Inc, San Diego, California, USA.

Alexander Schubert (A)

European College of Neuropsychopharmacology (ECNP), Utrecht, Netherlands.

Srdjan Djurovic (S)

Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; NORMENT Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.

Hakon Heimer (H)

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Nordic Society of Human Genetics and Precision Medicine, Copenhagen, Denmark.

Hreinn Stefánsson (H)

deCODE Genetics, Reykjavik, Iceland.

Kári Stefánsson (K)

deCODE Genetics, Reykjavik, Iceland.

Thomas Werge (T)

Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.

Ida Sønderby (I)

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.

Michael C O'Donovan (MC)

Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.

James T R Walters (JTR)

Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Lili Milani (L)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia; Genetics and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia.

Ole A Andreassen (OA)

NORMENT, Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway. Electronic address: e.m.koch@medisin.uio.no.

Classifications MeSH