Assessment of liver function by gadoxetic acid avidity in MRI in a model of rapid liver regeneration in rats.

Journal

HPB : the official journal of the International Hepato Pancreato Biliary Association
ISSN: 1477-2574
Titre abrégé: HPB (Oxford)
Pays: England
ID NLM: 100900921

Informations de publication

Date de publication:
21 Dec 2023
Historique:
received: 06 09 2023
revised: 18 11 2023
accepted: 18 12 2023
medline: 8 1 2024
pubmed: 8 1 2024
entrez: 7 1 2024
Statut: aheadofprint

Résumé

This animal study investigates the hypothesis of an immature liver growth following ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by measuring liver volume and function using gadoxetic acid avidity in magnetic resonance imaging (MRI) in models of ALPPS, major liver resection (LR) and portal vein ligation (PVL). Wistar rats were randomly allocated to ALPPS, LR or PVL. In contrast-enhanced MRI scans with gadoxetic acid (Primovist®), liver volume and function of the right median lobe (=future liver remnant, FLR) and the deportalized lobes (DPL) were assessed until post-operative day (POD) 5. Liver function In ALPPS (n = 6), LR (n = 6) and PVL (n = 6), volume This study shows for the first time that functional increase is proportional to volume increase in ALPPS using gadoxetic acid avidity in MRI.

Sections du résumé

BACKGROUND BACKGROUND
This animal study investigates the hypothesis of an immature liver growth following ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by measuring liver volume and function using gadoxetic acid avidity in magnetic resonance imaging (MRI) in models of ALPPS, major liver resection (LR) and portal vein ligation (PVL).
METHODS METHODS
Wistar rats were randomly allocated to ALPPS, LR or PVL. In contrast-enhanced MRI scans with gadoxetic acid (Primovist®), liver volume and function of the right median lobe (=future liver remnant, FLR) and the deportalized lobes (DPL) were assessed until post-operative day (POD) 5. Liver function
RESULTS RESULTS
In ALPPS (n = 6), LR (n = 6) and PVL (n = 6), volume
DISCUSSION CONCLUSIONS
This study shows for the first time that functional increase is proportional to volume increase in ALPPS using gadoxetic acid avidity in MRI.

Identifiants

DOI: 10.1016/j.hpb.2023.12.007 PMID: 38185541
pubmed: 38185541
pii: S1365-182X(23)02042-7
doi: 10.1016/j.hpb.2023.12.007
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Conflict of interest No disclosures of potential conflicts (financial, professional or personal) relevant to the manuscript. Martin Schläpfer and Beatrice Beck-Schimmer have received unrestricted research funds from Sedana Medical, Danderyd, Sweden, and from Roche Diagnostics International, Rotkreuz, Switzerland. Beatrice Beck-Schimmer and Martin Schläpfer have submitted a patent to mitigate the negative effects of surgery and/or anesthesia for patients using medical gases, particularly oxygen (O2) and carbon dioxide (CO2). Beatrice Beck-Schimmer submitted US and EP patent applications for an injectable formulation for the treatment and protection of patients having an inflammatory reaction or an ischemia/reperfusion event.

Auteurs

Jan Heil (J)

Institute of Physiology, University of Zurich, Zurich, Switzerland; Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Germany.

Mark Augath (M)

Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.

Vartan Kurtcuoglu (V)

The Interface Group, Institute of Physiology, University of Zurich, Zurich, Switzerland.

Joachim Hohmann (J)

Department of Radiology and Nuclear Medicine, Cantonal Hospital Winterthur, Winterthur, Switzerland; Medical Faculty, University of Basel, Basel, Switzerland.

Wolf O Bechstein (WO)

Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Germany.

Pim Olthof (P)

Department of Surgery, Erasmus MC, Rotterdam, the Netherlands; Department of Surgery, Amsterdam UMC, Amsterdam, the Netherlands.

Andreas A Schnitzbauer (AA)

Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Germany.

Petra Seebeck (P)

Zurich Integrative Rodent Physiology (ZIRP), University of Zurich, Zurich, Switzerland.

Marc Schiesser (M)

Chirurgisches Zentrum Zürich (CZZ), Klinik Hirslanden Zurich, Zurich, Switzerland; Chirurgie Zentrum Zentralschweiz (CZZ) Hirslanden St. Anna, Lucerne, Switzerland.

Martin Schläpfer (M)

Institute of Physiology, University of Zurich, Zurich, Switzerland; Institute of Anesthesiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.

Beatrice Beck-Schimmer (B)

Institute of Physiology, University of Zurich, Zurich, Switzerland; Institute of Anesthesiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.

Erik Schadde (E)

Institute of Physiology, University of Zurich, Zurich, Switzerland; Chirurgisches Zentrum Zürich (CZZ), Klinik Hirslanden Zurich, Zurich, Switzerland; Chirurgie Zentrum Zentralschweiz (CZZ) Hirslanden St. Anna, Lucerne, Switzerland; Department of Surgery, Rush University Medical Center Chicago, IL, USA. Electronic address: erik.schadde@icloud.com.

Classifications MeSH