Role of Liraglutide Use in Patients With Heart Failure.

glp-1 analogs glucagon-like peptide-1 receptor agonist (glp-1 ra) heart failure with preserved ejection fraction heart failure with reduced ejection fraction liraglutide literature review  management of heart failure pub-med indexed research review of clinical trials

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Dec 2023
Historique:
accepted: 06 12 2023
medline: 8 1 2024
pubmed: 8 1 2024
entrez: 8 1 2024
Statut: epublish

Résumé

Heart failure is a clinical condition in which the heart is unable to maintain adequate cardiac output. Liraglutide is a glucagon-like peptide 1 (GLP-1) analogue that is used for the treatment of type 2 diabetes mellitus, but recent evidence suggests that it might have a beneficial role in treating heart failure. We conducted a review of existing literature and found five relevant studies. Data from these studies were extracted and then extrapolated into results following analysis. Four of the five studies found an increase in heart rate in heart failure patients. All five studies reported an increased rate of hospitalization. The five studies also showed an increased risk of adverse effects such as arrhythmia, ventricular tachycardia, atrial fibrillation, and worsening of heart failure. Given the scarcity of evidence in the available literature on liraglutide in heart failure, more research on this population is required.

Identifiants

pubmed: 38186489
doi: 10.7759/cureus.50065
pmc: PMC10769535
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

e50065

Informations de copyright

Copyright © 2023, Allam et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Auteurs

Sanjana Allam (S)

Internal Medicine, Gandhi Medical College, Secunderabad, IND.

Sahil Sartaj (S)

Internal Medicine, Melmaruvathur Adiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, IND.

Hiba Moquim (H)

Internal Medicine, Shadan Institute of Medical Sciences, Hyderabad, IND.

Muhammad Ammar Husnain (MA)

Internal Medicine, Combined Military Hospital Lahore Medical College and Institute of Dentistry, Lahore, PAK.

Daniel Bustos (D)

Internal Medicine, Pontifical Catholic University of Ecuador, Quito, ECU.

Mohit Lakkimsetti (M)

Internal Medicine, Mamata Medical College, Khammam, IND.

Avneet K Randhawa (AK)

Internal Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, IND.

Ishita Gupta (I)

Internal Medicine, Dr. Rajendra Prasad Government Medical College, Tanda, Kangra, IND.

Classifications MeSH