Microstructural alterations of major thalamic nuclei in the chronic pediatric spinal cord injured population.

Diffusion tensor imaging Magnetic resonance imaging Pediatrics Spinal cord injury Thalamus

Journal

World neurosurgery: X
ISSN: 2590-1397
Titre abrégé: World Neurosurg X
Pays: United States
ID NLM: 101747743

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 21 01 2023
revised: 12 07 2023
accepted: 28 11 2023
medline: 8 1 2024
pubmed: 8 1 2024
entrez: 8 1 2024
Statut: epublish

Résumé

The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs. To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics. 18 pediatric participants with chronic SCI (8-20 years) were stratified using the American Spinal Injury Association Impairment Scale (AIS) into groups: A, B, and C/D. DTI of the brain used a 3 T Siemens Verio MRI using the parameters: 20 directions, number of averages = 3, b = 1000 s/mm DTI metrics were acquired by superimposing the AAL3 thalamic atlas onto participant diffusion images registered to MNI152 space. We utilized a multiple Mann-Whitney U-test to compare between AIS groups, considering values of p ≤ 0.05 as significant. FA, AD, RD, and MD significantly differed in thalamic nuclei between AIS groups A vs B and B vs C/D. Significant nuclei include the right ventral anterior, left intralaminar, bilateral lateral pulvinar, and right lateral geniculate. Our findings suggest the presence of microstructural alterations based on SCI severity in pediatric patients. These results are encouraging and warrant further study.

Sections du résumé

Background UNASSIGNED
The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs.
Purpose UNASSIGNED
To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics.
Methods UNASSIGNED
18 pediatric participants with chronic SCI (8-20 years) were stratified using the American Spinal Injury Association Impairment Scale (AIS) into groups: A, B, and C/D. DTI of the brain used a 3 T Siemens Verio MRI using the parameters: 20 directions, number of averages = 3, b = 1000 s/mm
Data analysis UNASSIGNED
DTI metrics were acquired by superimposing the AAL3 thalamic atlas onto participant diffusion images registered to MNI152 space. We utilized a multiple Mann-Whitney U-test to compare between AIS groups, considering values of p ≤ 0.05 as significant.
Results UNASSIGNED
FA, AD, RD, and MD significantly differed in thalamic nuclei between AIS groups A vs B and B vs C/D. Significant nuclei include the right ventral anterior, left intralaminar, bilateral lateral pulvinar, and right lateral geniculate.
Conclusion UNASSIGNED
Our findings suggest the presence of microstructural alterations based on SCI severity in pediatric patients. These results are encouraging and warrant further study.

Identifiants

DOI: 10.1016/j.wnsx.2023.100268 PMID: 38187507 PMC: PMC10767188
pubmed: 38187507
doi: 10.1016/j.wnsx.2023.100268
pii: S2590-1397(23)00117-5
pmc: PMC10767188
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100268

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

Auteurs

K Kang (K)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

K Fleming (K)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

A Sathe (A)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

J Muller (J)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

J Harrop (J)

Department of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USA.

D Middleton (D)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

J E Heller (JE)

Department of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USA.

A Sharan (A)

Department of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA, 19107, USA.

F Mohamed (F)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

L Krisa (L)

Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

M Alizadeh (M)

Department of Neurosurgery, Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, 909 Walnut St., Philadelphia, PA, 19107, USA.

Classifications MeSH