In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019.
B/Victoria lineage
amino acid deletion
influenza outbreak
in‐field detection
Journal
Influenza and other respiratory viruses
ISSN: 1750-2659
Titre abrégé: Influenza Other Respir Viruses
Pays: England
ID NLM: 101304007
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
13
10
2023
revised:
06
12
2023
accepted:
10
12
2023
medline:
8
1
2024
pubmed:
8
1
2024
entrez:
8
1
2024
Statut:
epublish
Résumé
In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak. As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses. The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR). This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
Sections du résumé
Background
UNASSIGNED
In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.
Method
UNASSIGNED
As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.
Results
UNASSIGNED
The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR).
Conclusion
UNASSIGNED
This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
Identifiants
pubmed: 38188372
doi: 10.1111/irv.13246
pii: IRV13246
pmc: PMC10767671
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13246Informations de copyright
© 2024 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Déclaration de conflit d'intérêts
None declared.