Rational Design of Dinitroxide Polarizing Agents for Dynamic Nuclear Polarization to Enhance Overall NMR Sensitivity.
Hyperpolarization
NMR spectroscopy
dynamic nuclear polarization
nitroxide free radicals
polarizing agents
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
revised:
03
01
2024
received:
14
11
2023
accepted:
08
01
2024
medline:
9
1
2024
pubmed:
9
1
2024
entrez:
9
1
2024
Statut:
aheadofprint
Résumé
We evaluate the overall sensitivity gains provided by a series of eighteen nitroxide biradicals for dynamic nuclear polarization (DNP) solid-state NMR at 9.4 T and 100 K, including eight new biradicals. We find that in the best performing group the factors contributing to the overall sensitivity gains, namely the DNP enhancement, the build-up time, and the contribution factor, often compete with each other leading to very similar overall performance across a range of biradicals. NaphPol and HydroPol are found to provide the best overall sensitivity factors, in organic and aqueous solvents respectively. One of the new biradicals, AMUPolCbm, provides good sensitivity for all three solvent formulations measured here, and can be considered to be a "universal" polarization agent.
Identifiants
pubmed: 38193258
doi: 10.1002/anie.202317337
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202317337Informations de copyright
© 2024 Wiley-VCH GmbH.