Microbiome and Abdominopelvic Radiotherapy Related Chronic Enteritis: A Microbiome-based Mechanistic Role of Probiotics and Antibiotics.
Journal
American journal of clinical oncology
ISSN: 1537-453X
Titre abrégé: Am J Clin Oncol
Pays: United States
ID NLM: 8207754
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
medline:
9
1
2024
pubmed:
9
1
2024
entrez:
9
1
2024
Statut:
aheadofprint
Résumé
Chronic diarrhea and abdominal pain after radiotherapy continue to be a problem in cancer survivors. Gut microbiomes are essential for preventing intestinal inflammation, maintaining intestinal integrity, maintaining enterohepatic circulation, regulating bile acid metabolism, and absorption of nutrients, including fat-soluble vitamins. Gut microbiome dysbiosis is expected to cause inflammation, bile acid malabsorption, malnutrition, and associated symptoms. Postradiotherapy, Firmicutes and Bacteroidetes phylum are significantly decreased while Fusobacteria and other unclassified bacteria are increased. Available evidence suggests harmful bacteria Veillonella, Erysipelotrichaceae, and Ruminococcus are sensitive to Metronidazole or Ciprofloxacin. Beneficial bacteria lactobacillus and Bifidobacterium are relatively resistant to metronidazole. We hypothesize and provide an evidence-based review that short-course targeted antibiotics followed by specific probiotics may lead to alleviation of radiation enteritis.
Identifiants
pubmed: 38193365
doi: 10.1097/COC.0000000000001082
pii: 00000421-990000000-00168
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest.
Références
Armes J, Crowe M, Colbourne L, et al. Patients’ supportive care needs beyond the end of cancer treatment: a prospective, longitudinal survey. J Clin Oncol. 2009;27:6172–6179.
Andreyev HJN, Davidson S, Gillespie C, et al. Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer. Gut. 2012;61:179–192.
Nout RA, Putter H, Jürgenliemk-Schulz IM, et al. Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial. J Clin Oncol. 2009;27:3547–3556.
Chopra S, Gupta S, Kannan S, et al. Late toxicity after adjuvant conventional radiation versus image-guided intensity-modulated radiotherapy for cervical cancer (PARCER): a randomized controlled trial. J Clin Oncol. 2021;39:3682–3692.
Andreyev HJ, Benton BE, Lalji A, et al. Algorithm-based management of patients with gastrointestinal symptoms in patients after pelvic radiation treatment (ORBIT): a randomized controlled trial. Lancet. 2013;382:2084–2092.
Danielsson A, Nyhlin H, Persson H, et al. Chronic diarrhea after radiotherapy for gynecological cancer: occurrence and etiology. Gut. 1991;32:1180–1187.
Mclaughlin MM, Dacquisto MP, Jacobus DP, et al. Effects of the germfree state on responses of mice to whole-body irradiation. Radiat Res. 1964;23:333–349.
Ding X, Li Q, Li P, et al. Fecal microbiota transplantation: a promising treatment for radiation enteritis? Radiother Oncol. 2020;143:12–18.
Li N, Tian HL, Chen QY, et al. Efficacy analysis of fecal microbiota transplantation in the treatment of 2010 patients with intestinal disorders. Zhonghua Wei Chang Wai Ke Za Zhi. 2019;22:861–868; Chinese.
Zhao Z, Cheng W, Qu W, et al. Antibiotic alleviates radiation-induced intestinal injury by remodeling microbiota, reducing inflammation, and inhibiting fibrosis. ACS Omega. 2020;5:2967–2977.
Patangia DV, Anthony Ryan C, Dempsey E, et al. Impact of antibiotics on the human microbiome and consequences for host health. Microbiol Open. 2022;11:e1260.
Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022–1023.
Lazar V, Ditu LM, Pircalabioru GG, et al. Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer. Front Immunol. 2018; 9:1830.
Molinero N, Ruiz L, Sánchez B, et al. Intestinal bacteria interplay with bile and cholesterol metabolism: implications on host physiology. Front Physiol. 2019;10:185.
García JL, Uhía I, Galán B. Catabolism and biotechnological applications of cholesterol degrading bacteria. Microb Biotechnol. 2012;5:679–699.
Gérard P, Béguet F, Lepercq P, et al. Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion. FEMS Microbiol Ecol. 2004;47:337–343.
Carbonero F, Benefiel AC, Alizadeh-Ghamsari AH, et al. Microbial pathways in colonic sulfur metabolism and links with health and disease. Front Physiol. 2012;3:448.
Ridlon JM, Kang DJ, Hylemon PB. Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. Anaerobe. 2010;16:137–146.
Ridlon JM, Harris SC, Bhowmik S, et al. Consequences of bile salt biotransformations by intestinal bacteria. Gut Microbes. 2016;7:22–39.
Hamilton JP, Xie G, Raufman JP, et al. Human cecal bile acids: Concentration and spectrum. Am J Physiol Gastrointest Liver Physiol. 2007;293:G 256–G 263.
Parada Venegas D, De la Fuente MK, Landskron G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.
Wlodarska M, Luo C, Kolde R, et al. Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation. Cell Host Microbe. 2017;22:25–37. e6.
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474:1823–1836.
Gagnière J, Raisch J, Veziant J, et al. Gut microbiota imbalance and colorectal cancer. World J Gastroenterol. 2016;22:501–518.
Rebersek M. Gut microbiome and its role in colorectal cancer. BMC Cancer. 2021;21:1325.
Chang L, Qiu L, Lei N, et al. Characterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis. Front Cell Infect Microbiol. 2023;13:1145950.
Wang L, Wang X, Zhang G, et al. The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhea: a systematic review. Radiat Oncol. 2021;16:187.
Vacca M, Celano G, Calabrese FM, et al. The controversial role of human gut lachnospiraceae. Microorganisms. 2020;8:573.
Choo JM, Kanno T, Zain NM, et al. Divergent relationships between fecal microbiota and metabolome following distinct antibiotic-induced disruptions. mSphere. 2017;2:e00005–e00017.
Plaza-Diaz J, Gil A. Gut Microbiota: Dietary Interactions; Encyclopedia of Human Nutrition, Fourth Edition. Cambridge (USA): Academic press; 2023.
Zhan Z, Liu W, Pan L, et al. Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway. Cell Death Discov. 2022;8:251.
Litterio M, Matteo M, Fiorilli G, et al. Susceptibility of veillonella spp. To ten different antibiotics. Anaerobe. 1999;5:477–478.
Kaakoush NO. Insights into the role of erysipelotrichaceae in the human host. Front Cell Infect Microbiol. 2015;5:84.
Ubeda C, Taur Y, Jenq RR, et al. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest. 2010;120:4332–4341.
Crost EH, Coletto E, Bell A, et al. Ruminococcus gnavus: Friend or foe for human health. FEMS Microbiol Rev. 2023;47:fuad014.
Ecale F, El Houari A, Crapart S, et al. In vitro sensitivity of 30 anaerobic bacterial strains of the human intestinal core microbiota to antibiotics: Culture and LC-MS/MS approaches. Anaerobe. 2021;67:102314.
Wu F, Guo X, Zhang J, et al. Phascolarctobacterium faecium abundant colonization in human gastrointestinal tract. Exp Ther Med. 2017;14:3122–3126.
Lopetuso LR, Scaldaferri F, Petito V, et al. Commensal Clostridia: Leading players in the maintenance of gut homeostasis. Gut Pathog. 2013;5:23.
Guo P, Zhang K, Ma X, et al. Clostridium species as probiotics: Potentials and challenges. J Animal Sci Biotechnol. 2020;11:24.
Prete R, Long SL, Gallardo AL, et al. Beneficial bile acid metabolism from Lactobacillus plantarum of food origin. Sci Rep. 2020;10:1165.
Pike LJ Characterizing antibiotic susceptibility and resistance in human commensal gut bacteria. 2020; Available from. https://www.repository.cam.ac.uk/handle/1810/298913
O’Callaghan A, van Sinderen D. Bifidobacteria and their role as members of the human gut microbiota. Front Microbiol. 2016;7:925.
Parsaei M, Sarafraz N, Moaddab SY, et al. The importance of Faecalibacterium prausnitzii in human health and diseases. New Microbes New Infect. 2021;43:100928.
Gillespie SH. Chapter 8 - Anaerobes, Medical Microbiology Illustrated. Oxford (UK): Butterworth-Heinemann; 1994;92–107.
Legaria MC, Nastro M, Camporro J, et al. Peptostreptococcus anaerobius: Pathogenicity, identification, and antimicrobial susceptibility. Review of monobacterial infections and addition of a case of urinary tract infection directly identified from a urine sample by MALDI-TOF MS. Anaerobe. 2021;72:102461.
Könönen E, Bryk A, Niemi P, et al. Antimicrobial susceptibilities of Peptostreptococcus anaerobius and the newly described Peptostreptococcus stomatis isolated from various human sources. Antimicrob Agents Chemother. 2007;51:2205–2207.
Nie K, Ma K, Luo W, et al. Roseburia intestinalis: a Beneficial gut organism from the discoveries in genus and species. Front Cell Infect Microbiol. 2021;11:757718.
Zhang C, Ma K, Nie K, et al. Assessment of the safety and probiotic properties of Roseburia intestinalis: a potential “Next Generation Probiotic”. Front Microbiol. 2022;13:973046.
Reis Ferreira M, Andreyev HJN, Mohammed K, et al. Microbiota- and radiotherapy-induced gastrointestinal side-effects (MARS) study: a large pilot study of the microbiome in acute and late-radiation enteropathy. Clin Cancer Res. 2019;25:6487–6500.
Zhao TS, Xie LW, Cai S, et al. Dysbiosis of gut microbiota is associated with the progression of radiation-induced intestinal injury and is alleviated by oral compound probiotics in mouse model. Front Cell Infect Microbiol. 2021;11:717636.
Cavcić J, Turcić J, Martinac P, et al. Metronidazole in the treatment of chronic radiation proctitis: Clinical trial. Croat Med J. 2000;41:314–318.
Albenberg L, Esipova TV, Judge CP, et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology. 2014;147:1055–63. e8.
Yuan JH, Song LM, Liu Y, et al. The effects of hyperbaric oxygen therapy on pelvic radiation induced gastrointestinal complications (rectal bleeding, diarrhea, and pain): a meta-analysis. Front Oncol. 2020;10:390.
Devaraj NK, Suppiah S, Veettil SK, et al. The effects of probiotic supplementation on the incidence of diarrhea in cancer patients receiving radiation therapy: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials. Nutrients. 2019;11:2886.
Otterson MF. Effects of radiation upon gastrointestinal motility. World J Gastroenterol. 2007;13:2684–2692.