Two cases of viral re-suppression after M184V + R263 K selection on DTG/3TC without treatment modification.
Dolutegravir
HIV
M184 V
R263 K
Resistance
lamivudine
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
received:
17
11
2023
revised:
29
12
2023
accepted:
04
01
2024
medline:
9
1
2024
pubmed:
9
1
2024
entrez:
9
1
2024
Statut:
aheadofprint
Résumé
DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we attribute to residual drug activity, reduced viral fitness, and robust immune competence.
Identifiants
pubmed: 38193816
pii: 7513305
doi: 10.1093/cid/ciae006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.