Heterogeneous Nuclear Ribonucleoprotein F Deficiency in Mouse Podocyte Promotes Podocytopathy Mediated by Methyltransferase-like 14 Nuclear Translocation Resulting in Sirtuin-1 Gene Inhibition.

HnRNP F Mettl14 Sirt1 and Podocytopathy

Journal

Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339

Informations de publication

Date de publication:
07 Jan 2024
Historique:
received: 11 08 2023
revised: 25 11 2023
accepted: 06 01 2024
medline: 10 1 2024
pubmed: 10 1 2024
entrez: 9 1 2024
Statut: aheadofprint

Résumé

Heterogeneous nuclear ribonucleoprotein F (HnRNP F) is a key regulator for nucleic acid metabolism; however, whether HnRNP F expression is important in maintaining podocyte integrity is unclear. Nephroseq analysis from a registry of human kidney biopsies was performed. Age- and sex-matched podocyte-specific HnRNP F knockout (HnRNP F

Identifiants

DOI: 10.1016/j.trsl.2024.01.002 PMID: 38195017
pubmed: 38195017
pii: S1931-5244(24)00012-4
doi: 10.1016/j.trsl.2024.01.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest All authors have nothing to disclose.

Auteurs

Min-Chun Liao (MC)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Chao-Sheng Lo (CS)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Yu-Chao Pang (YC)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Wen-Xia Yang (WX)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Ke Su (K)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Xin-Ping Zhao (XP)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Kana N Miyata (KN)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9; Division of Nephrology, Department of Internal Medicine, Saint Louis University, 1008 Spring Ave. St Louis, MO, U.S.A. 63110.

Junzheng Peng (J)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9.

Julie R Ingelfinger (JR)

Pediatric Nephrology Unit, Mass General Hospital for Children at Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, U.S.A. 02114.

John S D Chan (JSD)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9. Electronic address: john.chan@umontreal.ca.

Shao-Ling Zhang (SL)

Department of Medicine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montréal, QC, Canada H2×0A9. Electronic address: shao.ling.zhang@umontreal.ca.

Classifications MeSH