Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients.
Critically Ill patients
Intensive care unit
Mortality
Vitamin D
Vitamin D Deficiency
Journal
BMC nutrition
ISSN: 2055-0928
Titre abrégé: BMC Nutr
Pays: England
ID NLM: 101672434
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
received:
16
01
2023
accepted:
24
11
2023
medline:
10
1
2024
pubmed:
10
1
2024
entrez:
9
1
2024
Statut:
epublish
Résumé
Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient's serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score. A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63-14.27; P = 0.004). The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate.
Sections du résumé
BACKGROUND & OBJECTIVE
OBJECTIVE
Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status.
MATERIALS AND METHODS
METHODS
In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient's serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score.
RESULTS
RESULTS
A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P < 0.001), and mNUTRIC scores (P = 0.01). Patients with sufficient levels of vitamin D (> 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63-14.27; P = 0.004).
CONCLUSION
CONCLUSIONS
The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate.
Identifiants
pubmed: 38195535
doi: 10.1186/s40795-023-00801-1
pii: 10.1186/s40795-023-00801-1
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6Informations de copyright
© 2024. The Author(s).
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