Red blood cell transfusion-related dynamics of extracellular vesicles in intensive care patients: a prospective subanalysis.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 Jan 2024
Historique:
received: 12 06 2023
accepted: 23 11 2023
medline: 10 1 2024
pubmed: 10 1 2024
entrez: 9 1 2024
Statut: epublish

Résumé

Extracellular vesicles (EVs) accumulate during packed red blood cell (PRBC) storage. To date, the involvement of EVs in transfusion-related immunomodulation (TRIM) has not been prospectively evaluated in intensive care unit (ICU) patients. This was a prospective subanalysis of a recent observational feasibility study in postoperative ICU patients after: (1) open aortic surgery (Aorta), (2) bilateral lung transplantation (LuTx), and (3) other types of surgery (Comparison). Patient plasma was collected three times each before and after leukoreduced PRBC transfusion at 30-min intervals. The total number of EVs and EVs derived from erythrocytes (EryEVs), total platelets (total PEVs), activated platelets, granulocytes (GEVs), monocytes, and myeloid cells in PRBC samples and patient plasma were analyzed by flow cytometry. Statistical analysis was performed by Spearman's correlation test, linear mixed models and pairwise comparisons by Wilcoxon matched-pairs test. Twenty-three patients (Aorta n = 5, LuTx n = 9, Comparison n = 9) were included in the final analysis. All EV subgroups analyzed were detectable in all PRBCs samples (n = 23), but concentrations did not correlate with storage time. Moreover, all EVs analyzed were detectable in all plasma samples (n = 138), and EV counts were consistent before transfusion. Concentrations of total EVs, EryEVs, total PEVs, and GEVs increased after transfusion compared with baseline in the entire cohort but not in specific study groups. Furthermore, the change in plasma EV counts (total EVs and EryEVs) after transfusion correlated with PRBC storage time in the entire cohort. Extracellular vesicles were detectable in all PRBC and plasma samples. Individual EV subtypes increased after transfusion in the entire cohort, and in part correlated with storage duration. Future clinical studies to investigate the role of EVs in TRIM are warranted and should anticipate a larger sample size.Trial registration: Clinicaltrials.gov: NCT03782623.

Identifiants

pubmed: 38195728
doi: 10.1038/s41598-023-48251-w
pii: 10.1038/s41598-023-48251-w
doi:

Banques de données

ClinicalTrials.gov
['NCT03782623']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

911

Subventions

Organisme : Medical Scientific Fund of the Mayor of the City of Vienna
ID : 19046

Informations de copyright

© 2024. The Author(s).

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Auteurs

Pierre Raeven (P)

Division of General Anesthesia and Intensive Care, Department of Anesthesia, General Intensive Care, and Pain Management, Medical University of Vienna, Vienna, Austria.

Katharina Karlhofer (K)

Division of General Anesthesia and Intensive Care, Department of Anesthesia, General Intensive Care, and Pain Management, Medical University of Vienna, Vienna, Austria.
Division of Visceral Surgery, Department of Surgery, and Core Facility Flow Cytometry, Medical University of Vienna, Vienna, Austria.

Larissa S Sztulman (LS)

Division of Visceral Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Jonas Brugger (J)

Center for Medical Statistics, Informatics, and Intelligent Systems, Section for Medical Statistics, Medical University of Vienna, Vienna, Austria.

Konrad Hoetzenecker (K)

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Christoph Domenig (C)

Division of Vascular Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Gerda Leitner (G)

Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.

Martin Posch (M)

Center for Medical Statistics, Informatics, and Intelligent Systems, Section for Medical Statistics, Medical University of Vienna, Vienna, Austria.

David M Baron (DM)

Division of General Anesthesia and Intensive Care, Department of Anesthesia, General Intensive Care, and Pain Management, Medical University of Vienna, Vienna, Austria.

Andreas Spittler (A)

Division of Visceral Surgery, Department of Surgery, and Core Facility Flow Cytometry, Medical University of Vienna, Vienna, Austria. andreas.spittler@meduniwien.ac.at.

Classifications MeSH